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Autologous cell therapy for aged human skin: A randomized, placebo-controlled, phase-I study
YesIntroduction: Skin ageing involves senescent fibroblast accumulation, disturbance in extracellular matrix (ECM) homeostasis, and decreased collagen synthesis. Objective: to assess a cell therapy product for aged skin (RCS-01; verum) consisting of ~25 × 106 cultured, autologous cells derived from anagen hair follicle non-bulbar dermal sheath (NBDS). Methods: For each subject in the verum group, 4 areas of buttock skin were injected intradermally 1 or 3 times at monthly intervals with RCS-01, cryomedium, or needle penetration without injection; in the placebo group RCS-01 was replaced by cryomedium. The primary endpoint was assessment of local adverse event profiles. As secondary endpoints, expression of genes related to ECM homeostasis was assessed in biopsies from randomly selected volunteers in the RCS-01 group taken 4 weeks after the last injection. Results: Injections were well tolerated with no severe adverse events reported 1 year after the first injection. When compared with placebo-treated skin, a single treatment with RCS-01 resulted in a significant upregulation of TGFβ1, CTGF, COL1A1, COL1A2, COL3A1, and lumican mRNA expression. Limitations: The cohort size was insufficient for dose ranging evaluation and subgroup analyses of efficacy. Conclusions: RCS-01 therapy is well tolerated and associated with a gene expression response consistent with an improvement of ECM homeostasis.Replicel Life Sciences Inc, Vancouver, Canada
Photo- and Electron-Production of Mesons on Nucleons and Nuclei
In these lectures I will show some results obtained with the chiral unitary
approach applied to the photo and electroproduction of mesons. The results for
photoproduction of and , together with
related reactions will be shown, having with common denominator the excitation
of the resonance which is one of those dynamically generated in
the chiral unitary approach. Then I will show results obtained for the reaction which reproduce the bulk of the data except for a
pronounced peak, giving support to a new mesonic resonance, X(2175). Results
will also be shown for the electromagnetic form factors of the
resonance, also dynamically generated in this approach. Finally, I will show
some results on the photoproduction of the in nuclei, showing that
present experimental results claiming a shift of the mass in the
medium are tied to a particular choice of background and are not conclusive.
One the other hand, the same experimental results show unambiguously a huge
increase of the width in the nuclear medium.Comment: Lecture at the "International School of Nuclear Physics", 29th Course
Quarks in Hadrons and Nuclei, Erice, Italy, September 2007. Note added in
Proofs concerning the mixed events technique and other comments on omega
productio
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