Рациональный компромисс целей субъектов дистанционного образования

На базе системной методологии исследованы механизмы согласования деятельности субъектов в дистанционном образовании для нахождения рационального компромисса целей субъектов обучения, учебных заведений и агентов рынка труда. На схемах взаимосвязей компонентов системы образования в процессе обучения и на схеме взаимодействия учебных заведений проиллюстрированы преимущества такого подхода. Предложена математическая постановка задачи обеспечения рационального компромисса целей. Разработан алгоритм ее решения.На основі системної методології досліджено механізми погодження діяльності суб’єктів у дистанційній освіті з метою знаходження раціонального компромісу цілей суб’єктів навчання, навчальних закладів та агентів ринку праці. На схемах взаємозв’язків компонентів системи освіти у процесі навчання та на схемі взаємодії навчальних закладів проілюстровано переваги такого підходу. Запропоновано математичну модель задачі знаходження раціонального компромісу цілей та наведено алгоритм її розв’язку.Coordination mechanisms for agents purposes in the distance education have been studied on the basis of system methodology. The finding of rational compromise for purposes of learners, educational institutions and labour market agents is proposed. Benefits of the approach are illustrated by the scheme of education system components interconnection during the learning process and the scheme of educational institutions interaction. A mathematical model and an algorithm for finding the rational compromise of purposes are given

Ultrastructural Cytochemistry of the Tegumental Surface Membrane of Paragonimus Kellicotti

Paper by Francis M. Gress and Richard D. Lumsde

Determining the role of epigenetic factors in antifungal drug resistance

Epigenetic factors are proteins that regulate gene expression by altering transcriptional machinery access to nucleosomes, DNA wrapped around histone proteins. Two classes of epigenetic factors are ATP-dependent chromatin remodelers and histone modifiers such as histone methyltransferases (HMTs), proteins that add methyl groups to histone tails. This study focuses on AIF4 (Antifungal-Induced Factor 4), a possible HMT induced upon neutral lipid depletion that we hypothesize is regulating antifungal drug resistance genes. Overexpression of AIF4 results in hypersensitivity to antifungal drugs. Studying epigenetic factors in the yeast Saccharomyces cerevisiae, including AIF4, can lead to better understanding of cell adaptation to their environments and insight into antifungal drug resistance of pathogenic yeast. This project will focus on identifying suppressors of AIF4’s hypersensitive phenotype and exploring whether genes in the neutral lipid pathway are necessary for AIF4 expression. To support our hypothesis, I will grow yeast colonies with overexpressed AIF4 on media containing antifungal drugs. Overexpressing AIF4 strains exposed to antifungal drugs over time suppressed the grow defect. Re-plating the suppressor colonies showed drug resistance, suggesting that a genetic mutation(s) occurred. Suppressor colonies will be analyzed for AIF4 expression and genome-wide sequencing to identify the suppressor mutation(s). In addition, I have generated deletions for genes that encode neutral lipid production enzymes, and I will determine if AIF4 expression is affected. Single and double deletions will determine if a particular neutral lipid is required for the expression of AIF4. Overall, my work will help to characterize a pathway required for AIF4 expression and drug resistance

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metastasis. More recently, the tumor microenvironment has also been appreciated to mediate therapeutic resistance in pancreatic ductal adenocarcinoma, thus opening numerous avenues for novel therapeutic explorations. Inert and soluble components of the tumor stroma have been targeted in order to break down the extracellular matrix scaffold, relieve vessel compression, and increase drug delivery to hypovascular tumors. Moreover, targeting of antiapoptotic, immunosuppressive, and pro-proliferative effects of the tumor stroma provides novel vantage points of attack. This review focuses on current and future developments in pancreatic cancer medicine, with a particular emphasis on biophysical and biochemical approaches that target the tumor microenvironment

The Tunka Experiment: Towards a 1-km^2 Cherenkov EAS Array in the Tunka Valley

The project of an EAS Cherenkov array in the Tunka valley/Siberia with an area of about 1 km^2 is presented. The new array will have a ten times bigger area than the existing Tunka-25 array and will permit a detailed study of the cosmic ray energy spectrum and the mass composition in the energy range from 10^15 to 10^18 eV.Comment: 3 pages, 2 figures, to be published in IJMP