2 research outputs found
Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer
Three metabolite patterns have previously shown prospective inverse associations with
the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer
and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate
cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins
(Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern
2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524)
and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations
of 24 dietary and lifestyle variables with each pattern and the contributing individual
metabolites. Associations statistically significant after both correction for multiple testing (False
Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered
robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively
associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which
appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty
fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish
and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of
aggressive prostate cancer.Cancer Research UK C8221/A30904
C8221/A29017World Health OrganizationDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonDanish Cancer SocietyLigue Contre le Cancer (France)
Institut Gustave Roussy (France)
Mutuelle Generale de l'Education Nationale (France)Institut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeGerman Cancer Research Center (DKFZ) (Germany)
German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany)Federal Ministry of Education & Research (BMBF)Fondazione AIRC per la ricerca sul cancro
Compagnia di San Paolo
Consiglio Nazionale delle Ricerche (CNR)Netherlands Government
Netherlands GovernmentWorld Cancer Research Fund International (WCRF)Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII) (Spain)Junta de AndaluciaPrincipality of AsturiasRegional Government of Basque Country (Spain)
Regional Government of Murcia (Spain)
Regional Government of Navarra (Spain)
Catalan Institute of Oncology-ICO (Spain)Swedish Cancer Society
Swedish Research Council
County Council of Skane (Sweden)
County Council of Vasterbotten (Sweden)UK Research & Innovation (UKRI)
Medical Research Council UK (MRC) 1000143
MR/N003284/1
MC-UU_12015/1
MC_UU_00006/1
MR/M012190/
Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer
Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer