354 research outputs found
The Effects of X-rays and Beta Rays (Tritium) on the Growth of \u3cem\u3eRickettsia mooseri\u3c/em\u3e and \u3cem\u3eRickettsia akari\u3c/em\u3e in Embryonate Eggs
The growth of Rickettsia mooseri was accelerated and quantitatively increased in embryonate eggs containing tritium oxide at levels of 180, 90, and 45 mc./egg during the growth period. The eggs of a group containing 22.5 mc./egg showed only a slight increase in the rate of growth of organisms; the infections in the eggs of a group given 11.2 mc./egg did not differ significantly from those of the control group. On the other hand, growth of R. akari was inhibited in embryonate eggs containing tritium oxide at levels of 180, 90, and 45 mc./egg, and partially inhibited in groups containing 22.5 and 11.2 mc./egg. The patterns of growth of R. mooseri and of R. akari exposed to tritium oxide for 6 hours prior to inoculation into embryonate eggs did not differ significantly from that of the control group
Allergic Rhinoconjunctivitis: the Role of Histamine
Allergic rhinoconjunctivitis is the most common atopic condition
encountered in clinical practice. Analysis of the pathogenesis of
this condition permits identification of optimal therapeutic
targets. The increased knowledge of the underlying pathophysiology
suggests that multiple inflammatory mediators are involved in the
pathogenesis of the allergic reaction in the ocular and nasal
mucosa. However, despite the presence of a wide range of different
mediators, it would appear that histamine plays a key role.
Experimental allergen challenge studies have demonstrated that
histamine is the only mediator which produces the full spectrum of
clinical manifestations of the acute allergic reaction when applied
to the mucosal surface. While both H1- and H2-receptors are present
in the nasal and ocular mucosa, only H1-receptor antagonists are
capable of inhibiting histamine-induced symptoms of allergic
rhinoconjunctivitis. Furthermore, although the exact role of
histamine in the immediate and prolonged allergic reaction has not
yet been fully elucidated, these findings do not exclude the
possibility that histamine is involved in these processes. The
available evidence therefore supports current clinical practice for
use of H1-receptor antagonist as a first-line therapy in
patients with this atopic condition
Toward Quantum Superposition of Living Organisms
The most striking feature of quantum mechanics is the existence of
superposition states, where an object appears to be in different situations at
the same time. The existence of such states has been tested with small objects,
like atoms, ions, electrons and photons, and even with molecules. More
recently, it has been possible to create superpositions of collections of
photons, atoms, or Cooper pairs. Current progress in optomechanical systems may
soon allow us to create superpositions of even larger objects, like micro-sized
mirrors or cantilevers, and thus to test quantum mechanical phenomena at larger
scales. Here we propose a method to cool down and create quantum superpositions
of the motion of sub-wavelength, arbitrarily shaped dielectric objects trapped
inside a high--finesse cavity at a very low pressure. Our method is ideally
suited for the smallest living organisms, such as viruses, which survive under
low vacuum pressures, and optically behave as dielectric objects. This opens up
the possibility of testing the quantum nature of living organisms by creating
quantum superposition states in very much the same spirit as the original
Schr\"odinger's cat "gedanken" paradigm. We anticipate our essay to be a
starting point to experimentally address fundamental questions, such as the
role of life and consciousness in quantum mechanics.Comment: 9 pages, 4 figures, published versio
Effects of a dual CCR3 and H1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitis
<p>Abstract</p> <p>Background</p> <p>The CC-chemokine receptor-3 (CCR3) has emerged as a target molecule for pharmacological intervention in allergic inflammation.</p> <p>Objective</p> <p>To examine whether a dual CCR3 and H<sub>1</sub>-receptor antagonist (AZD3778) affects allergic inflammation and symptoms in allergic rhinitis.</p> <p>Methods</p> <p>Patients with seasonal allergic rhinitis were subjected to three seven days' allergen challenge series. Treatment with AZD3778 was given in a placebo and antihistamine-controlled design. Symptoms and nasal peak inspiratory flow (PIF) were monitored in the morning, ten minutes post challenge, and in the evening. Nasal lavages were carried out at the end of each challenge series and α<sub>2</sub>-macroglobulin, ECP, and tryptase were monitored as indices of allergic inflammation.</p> <p>Results</p> <p>Plasma levels of AZD3778 were stable throughout the treatment series. AZD3778 and the antihistamine (loratadine) reduced rhinitis symptoms recorded ten minutes post challenge during this period. AZD3778, but not the anti-histamine, also improved nasal PIF ten minutes post challenge. Furthermore, scores for morning and evening nasal symptoms from the last five days of the allergen challenge series showed statistically significant reductions for AZD3778, but not for loratadine. ECP was reduced by AZD3778, but not by loratadine.</p> <p>Conclusions</p> <p>AZD3778 exerts anti-eosinophil and symptom-reducing effects in allergic rhinitis and part of this effect can likely be attributed to CCR3-antagonism. The present data are of interest with regard to the potential use of AZD3778 in allergic rhinitis and to the relative importance of eosinophil actions to the symptomatology of allergic rhinitis.</p> <p>Trial registration</p> <p>EudraCT No: 2005-002805-21.</p
Search for Bremsstrahlung radiation in quasi-free n p --> n p gamma reactions
Due to the high sensitivity of the N N --> N N gamma reaction to the
nucleon-nucleon potential, Bremsstrahlung radiation is used as a tool to
investigate details of the nucleon-nucleon interaction. Such investigations can
be performed at the cooler synchrotron COSY in the Research Centre Juelich, by
dint of the COSY-11 detection system. The results of the identification of
Bremsstrahlung radiation emitted via the d p --> d p gamma reaction in data
taken with a proton target and a deuteron beam are presented and discussed.Comment: 3 pages; Presented at Meson 2004: 8th International Workshop on Meson
Production, Properties and Interaction, Krakow, Poland, 4-8 June 2004;
Submitted to International Journal of Modern Physics
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