44 research outputs found
Mesoscopic Superconducting Disc with Short-Range Columnar Defects
Short-range columnar defects essentially influence the magnetic properties of
a mesoscopic superconducting disc.They help the penetration of vortices into
the sample, thereby decrease the sample magnetization and reduce the upper
critical field. Even the presence of weak defects split a giant vortex state
(usually appearing in a clean disc in the vicinity of the transition to a
normal state) into a number of vortices with smaller topological charges. In a
disc with a sufficient number of strong enough defects vortices are always
placed onto defects. The presence of defects lead to the appearance of
additional magnetization jumps related to the redistribution of vortices which
are already present on the defects and not to the penetration of new vortices.Comment: 14 pgs. RevTex, typos and figures corrected. Submitted to Phys. Rev.
Cholesterol Metabolism Is Required for Intracellular Hedgehog Signal Transduction In Vivo
We describe the rudolph mouse, a mutant with striking defects in both central nervous system and skeletal development. Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in mediating intracellular Hedgehog (Hh) signaling. We see an abnormal sterol profile and decreased Hh target gene induction in the rudolph mutant, both in vivo and in vitro. Reduced Hh signaling has been proposed to contribute to the phenotypes of congenital diseases of cholesterol metabolism. Recent in vitro and pharmacological data also indicate a requirement for intracellular cholesterol synthesis for proper regulation of Hh activity via Smoothened. The data presented here are the first in vivo genetic evidence supporting both of these hypotheses, revealing a role for embryonic cholesterol metabolism in both CNS development and normal Hh signaling
A novel ESR2 frameshift mutation predisposes to medullary thyroid carcinoma and causes inappropriate RET expression
A review: Radiographic iodinated contrast media-induced thyroid dysfunction.
ContextThyroid hormone production is dependent on adequate iodine intake. Excess iodine is generally well-tolerated, but thyroid dysfunction can occur in susceptible individuals after excess iodine exposure. Radiological iodinated contrast media represent an increasingly common source of excess iodine.ObjectiveThis review will discuss the thyroidal response after acute exposure to excess iodine; contrast iodine-induced thyroid dysfunction; risks of iodine-induced thyroid dysfunction in vulnerable populations, such as the fetus, neonate, and patients with impaired renal function; and recommendations for the assessment and treatment of contrast iodine-induced thyroid dysfunction.MethodsData for this review were identified by searching PubMed, Google Scholar, and references from relevant articles from 1948 to 2014.ConclusionsWith the increase in the use of computed tomography scans in the United States, there is increasing risk of contrast-induced thyroid dysfunction. Patients at risk of developing iodine-induced thyroid dysfunction should be closely monitored after receiving iodinated contrast media and should be treated as needed