Current Black Men and Boys Investments in California: A Landscape Scan

The landscape of California philanthropy for black men and boys presented in this report is promising: It reveals a wide variety of innovative investments, potential for further coordination, and ways that efforts in California can be linked to work being done nationally

Discovery of a Radio-Selected z ~ 6 Quasar

We present the discovery of only the second radio-selected, z ~ 6 quasar. We identified SDSS J222843.54+011032.2 (z=5.95) by matching the optical detections of the deep Sloan Digital Sky Survey (SDSS) Stripe 82 with their radio counterparts in the Stripe82 VLA Survey. We also matched the Canadian-France-Hawaiian Telescope Legacy Survey Wide (CFHTLS Wide) with the Faint Images of the Radio Sky at Twenty-cm (FIRST) survey but have yet to find any z ~ 6 quasars in this survey area. The discovered quasar is optically-faint, z = 22.3 and M_{1450} ~ -24.5, but radio-bright, with a flux density of f$_{1.4GHz, peak}$ = 0.31mJy and a radio-loudness of R ~ 1100 (where R = f_{5GHz}/f_{2500}). The i-z color of the discovered quasar places it outside the color selection criteria for existing optical surveys. We conclude by discussing the need for deeper wide-area radio surveys in the context of high-redshift quasars.Comment: 20 pages, 6 figures, and ApJ accepte

Efficacy in Emergency Legal Preparedness Underlying the 2014 Ebola Outbreak

From its relative obscurity over the past three decades, Ebola viral disease (“EVD”) emerged as a substantial global biothreat in 2014 and 2015. The current outbreak of varied strains of Ebola, beginning in March 2014 in Guinea, is projected to impact hundreds of thousands of people over months, years, or even indefinitely. As of October 31, 2014, the spread of EVD was concentrated in several Af- rican countries (e.g., Sierra Leone, Liberia, Guinea, and an unrelated outbreak in Democratic Republic of Congo), with limited additional cases in Nigeria, Senegal, and Mali. Over 2,700 people are known to have died from Ebola in fewer than eight months in Liberia alone; the actual death toll may be far higher. At one point, the U.S. Centers for Disease Control and Prevention (“CDC”) estimated a worst-case scenario of 1.4 million new cases arising largely in already affected countries by early 2015. Reported cases in the affected regions are considerably less than these estimates, but with a fatality rate hovering near 50%, thousands more West Africans may perish before the end of this current outbreak

Efficacy in Emergency Legal Preparedness Underlying the 2014 Ebola Outbreak

From its relative obscurity over the past three decades, Ebola viral disease (“EVD”) emerged as a substantial global biothreat in 2014 and 2015. The current outbreak of varied strains of Ebola, beginning in March 2014 in Guinea, is projected to impact hundreds of thousands of people over months, years, or even indefinitely. As of October 31, 2014, the spread of EVD was concentrated in several Af- rican countries (e.g., Sierra Leone, Liberia, Guinea, and an unrelated outbreak in Democratic Republic of Congo), with limited additional cases in Nigeria, Senegal, and Mali. Over 2,700 people are known to have died from Ebola in fewer than eight months in Liberia alone; the actual death toll may be far higher. At one point, the U.S. Centers for Disease Control and Prevention (“CDC”) estimated a worst-case scenario of 1.4 million new cases arising largely in already affected countries by early 2015. Reported cases in the affected regions are considerably less than these estimates, but with a fatality rate hovering near 50%, thousands more West Africans may perish before the end of this current outbreak

Deep CO(1–0) Observations of z = 1.62 Cluster Galaxies with Substantial Molecular Gas Reservoirs and Normal Star Formation Efficiencies

We present an extremely deep CO(1–0) observation of a confirmed z = 1.62 galaxy cluster. We detect two spectroscopically confirmed cluster members in CO(1–0) with signal-to-noise ratio $\gt 5$. Both galaxies have log(${{ \mathcal M }}_{\star }$/${{ \mathcal M }}_{\odot }$) > 11 and are gas rich, with ${{ \mathcal M }}_{\mathrm{mol}}$/(${{ \mathcal M }}_{\star }$+${{ \mathcal M }}_{\mathrm{mol}}$) ~ 0.17–0.45. One of these galaxies lies on the star formation rate (SFR)–${{ \mathcal M }}_{\star }$ sequence, while the other lies an order of magnitude below. We compare the cluster galaxies to other SFR-selected galaxies with CO measurements and find that they have CO luminosities consistent with expectations given their infrared luminosities. We also find that they have gas fractions and star formation efficiencies (SFE) comparable to what is expected from published field galaxy scaling relations. The galaxies are compact in their stellar light distribution, at the extreme end for all high-redshift star-forming galaxies. However, their SFE is consistent with other field galaxies at comparable compactness. This is similar to two other sources selected in a blind CO survey of the HDF-N. Despite living in a highly quenched protocluster core, the molecular gas properties of these two galaxies, one of which may be in the process of quenching, appear entirely consistent with field scaling relations between the molecular gas content, stellar mass, star formation rate, and redshift. We speculate that these cluster galaxies cannot have any further substantive gas accretion if they are to become members of the dominant passive population in $z\lt 1$ clusters

SCARLET – A European Effort to Develop HTS and MgB2 Based MVDC Cables

Superconducting cables have been proven in a variety of pilot projects and utility installations, demonstrating several of their advantages, including compact size and low energy losses, which can make the technology economically attractive for certain applications. It is clear though that different applications impose different requirements and challenges, but also opportunities for the cables. An interesting application is high-power DC transfer at medium voltage (MVDC). The high-current capability of the superconductor allows for a reduction in voltage while maintaining or increasing the power transfer level. In this way, one MVDC superconducting cable can replace one or more conventional high-voltage DC cables. In the European project SCARLET (Superconducting cables for sustainable energy transition), two types of MVDC cables will be developed, one based on HTS and one on MgB2 materials. Additionally, protection requirements will be considered, including the development of a modular DC fault current limiter for 10 kA. A main motivation for the development is the elimination of costly high-voltage converter stations when going from high to medium voltage, e.g., for offshore wind power plants. Another feature is the combined hydrogen and electricity transmission from generation sites to industry or mobility end users. This paper describes the superconducting MVDC cable concept as well as the main challenges and research needed to develop and type test the cables.SCARLET – A European Effort to Develop HTS and MgB2 Based MVDC CablesacceptedVersio

The Human Connectome Project: A retrospective

The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study a large number of healthy young adults; and freely share the data and tools with the scientific community. NIH awarded grants to two consortia; this retrospective focuses on the WU-Minn-Ox HCP consortium centered at Washington University, the University of Minnesota, and University of Oxford. In just over 6 years, the WU-Minn-Ox consortium succeeded in its core objectives by: 1) improving MR scanner hardware, pulse sequence design, and image reconstruction methods, 2) acquiring and analyzing multimodal MRI and MEG data of unprecedented quality together with behavioral measures from more than 1100 HCP participants, and 3) freely sharing the data (via the ConnectomeDB database) and associated analysis and visualization tools. To date, more than 27 Petabytes of data have been shared, and 1538 papers acknowledging HCP data use have been published. The HCP-style neuroimaging paradigm has emerged as a set of best-practice strategies for optimizing data acquisition and analysis. This article reviews the history of the HCP, including comments on key events and decisions associated with major project components. We discuss several scientific advances using HCP data, including improved cortical parcellations, analyses of connectivity based on functional and diffusion MRI, and analyses of brain-behavior relationships. We also touch upon our efforts to develop and share a variety of associated data processing and analysis tools along with detailed documentation, tutorials, and an educational course to train the next generation of neuroimagers. We conclude with a look forward at opportunities and challenges facing the human neuroimaging field from the perspective of the HCP consortium

High Energy Replicated Optics to Explore the Sun: Hard X-Ray Balloon-Borne Telescope

Set to fly in the Fall of 2013 from Ft. Sumner, NM, the High Energy Replicated Optics to Explore the Sun (HEROES) mission is a collaborative effort between the NASA Marshall Space Flight Center and the Goddard Space Flight Center to upgrade an existing payload, the High Energy Replicated Optics (HERO) balloon-borne telescope, to make unique scientific measurements of the Sun and astrophysical targets during the same flight. The HEROES science payload consists of 8 mirror modules, housing a total of 109 grazing-incidence optics. These modules are mounted on a carbon-fiber - and Aluminum optical bench 6 m from a matching array of high pressure xenon gas scintillation proportional counters, which serve as the focal-plane detectors. The HERO gondola utilizes a differential GPS system (backed by a magnetometer) for coarse pointing in the azimuth and a shaft angle encoder plus inclinometer provides the coarse elevation. The HEROES payload will incorporate a new solar aspect system to supplement the existing star camera, for fine pointing during both the day and night. A mechanical shutter will be added to the star camera to protect it during solar observations. HEROES will also implement two novel alignment monitoring system that will measure the alignment between the optical bench and the star camera and between the optics and detectors for improved pointing and post-flight data reconstruction. The overall payload will also be discussed. This mission is funded by the NASA HOPE (Hands On Project Experience) Training Opportunity awarded by the NASA Academy of Program/Project and Engineering Leadership, in partnership with NASA's Science Mission Directorate, Office of the Chief Engineer and Office of the Chief Technologis

Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles in vitro

Apoptosis is a form of programmed cell death that occurs throughout life as part of normal development as well as pathologic processes including chronic inflammation and infection. Although the death of a cell is often considered as the only biological outcome of a cell committed to apoptosis, it is becoming increasingly clear that the dying cell can actively communicate with other cells via soluble factors as well as membrane-bound extracellular vesicles (EVs) to regulate processes including cell clearance, immunity and tissue repair. Compared to EVs generated from viable cells such as exosomes and microvesicles, apoptotic cell-derived EVs (ApoEVs) are less well defined and the basic criteria for ApoEV characterization have not been established in the field. In this study, we will examine the current understanding of ApoEVs, in particular, the ApoEV subtype called apoptotic bodies (ApoBDs). We described that a subset of ApoBDs can be larger than 5 μm and smaller than 1 μm based on flow cytometry and live time-lapse microscopy analysis, respectively. We also described that a subset of ApoBDs can expose a relatively low level of phosphatidylserine on its surface based on annexin A5 staining. Furthermore, we characterized the presence of caspase-cleaved proteins (in particular plasma membrane-associated or cytoplasmic proteins) in samples enriched in ApoBDs. Lastly, using a combination of biochemical-, live imaging- and flow cytometry-based approaches, we characterized the progressive lysis of ApoBDs. Taken together, these results extended our understanding of ApoBDs