The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 40.3

Jordan Conference in Florence, Paul J. Ray, Jr. Safra 2019, Paul Gregor, Paul Ray, and Jacob Moody Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1079/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 33.2

Tall Jalul 2012, Randall Younker, Paul Z. Gregor, and Paul J. Ray, Jr. Bridge Building, Kevin Burton Ceramic Finds: Typological and Technological Studies of the Pottery Remains from Tell Hesban and Vicinity Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1050/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 32.3

The 2011 Excavations at Tall Jalul, Randall W. Younker, Paul Z. Gregor, and Paul J. Ray, Jr. Dever Lectures, Jacob Moody Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1047/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 43.3

Khirbat Safra 2022, Paul Gregor, Robert Bates, Constance Gane, Trisha Broy, and Paul J. Ray, Jr. Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1091/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 37.2

Jordan Conference in Amman, Paul J. Ray, Jr. Jalul 2016, Paul Gregor, Constance E. Gane, Paul J. Ray, Jr., Robert D. Bates, and Randall W. Younker Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1066/thumbnail.jp

A Comparison of Data Sources for Motor Vehicle Crash Characteristic Accuracy

Objective: To determine the accuracy of police reports (PRs), ambulance reports (ARs), and emergency department records (EDRs) in describing motor vehicle crash (MVC) characteristics when compared with an investigation performed by an experienced crash investigator trained in impact biomechanics. Methods: This was a cross-sectional, observational study. Ninety-one patients transported by ambulance to a university emergency department (ED) directly from the scene of an MVC from August 1997 to April 1998 were enrolled. Potential patients were identified from the ED log and consent was obtained to investigate the crash vehicle. Data describing MVC characteristics were abstracted from the PR, AR, and medical record. Variables of interest included restraint use (RU), air bag deployment (AD), and type of impact (TI). Agreements between the variables and the independent crash investigation were compared using kappa. Interrater reliability was determined using kappa by comparing a random sample of 20 abstracted reports for each data source with the originally abstracted data. Results: Agreement using kappa between the crash investigation and each data source was 0.588 (95% CI = 0.508 to 0.667) for the PR, 0.330 (95% CI = 0.252 to 0.407) for the AR, and 0.492 (95% CI = 0.413 to 0.572) for the EDR. Variable agreement was 0.239 (95% CI = 0.164 to 0.314) for RU, 0.350 (95% CI = 0.268 to 0.432) for AD, and 0.631 (95%= 0.563 to 0.698) for TI. Interrater reliability was excellent (kappa > 0.8) for all data sources. Conclusions: The strength of the agreement between the independent crash investigation and the data sources that were measured by kappa was fair to moderate, indicating inaccuracies. This presents ramifications for researchers and necessitates consideration of the validity and accuracy of crash characteristics contained in these data sources.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75653/1/j.1553-2712.2000.tb02067.x.pd

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 31.3

Jordan Conference in Paris, Paul J. Ray, Jr. Jalul 2010, Randall W. Younker, Paul Z. Gregor, and Reem S. al-Shqor Dever Lecture, Owen Chesnut Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1043/thumbnail.jp

Detection of Mutant-Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules

The Huntington’s disease (HD) mutation leads to a complex process of Huntingtin (Htt) aggregation into multimeric species that eventually form visible inclusions in cytoplasm, nuclei and neuronal processes. One hypothesis is that smaller, soluble forms of amyloid proteins confer toxic effects and contribute to early cell dysfunction. However, analysis of mutant Htt aggregation intermediates to identify conformers that may represent toxic forms of the protein and represent potential drug targets remains difficult. We performed a detailed analysis of aggregation conformers in multiple in vitro, cell and ex vivo models of HD. Conformation-specific antibodies were used to identify and characterize aggregation species, allowing assessment of multiple conformers present during the aggregation process. Using a series of assays together with these antibodies, several forms could be identified. Fibrillar oligomers, defined as having ab-sheet rich conformation, are observed in vitro using recombinant protein and in protein extracts from cells in culture or mouse brain and shown to be globular, soluble and non-sedimentable structures. Compounds previously described to modulate visible inclusion body formation and reduce toxicity in HD models were also tested and consistently found to alter the formation of fibrillar oligomers. Interestingly, these compounds did not alter the rate of visible inclusion formation, indicating that fibrillar oligomers are not necessarily the rate limiting step of inclusion body formation. Taken together, we provide insights into the structure and formation of mutant Htt fibrillar oligomers that can be modulated by small molecules with protective potential in HD models

Improving Heart Failure Self-Management Support by Actively Engaging Out-of-Home Caregivers: Results of a Feasibility Study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72336/1/j.1751-7133.2008.07474.x.pd