THE CHANGING FACE OF PSYCHOLOGY: CAREER AND LEADERSHIP ASPIRATIONS OF FEMALE DOCTORAL STUDENTS IN COUNSELING AND CLINICAL PSYCHOLOGY

This study aimed to advance understanding of career-related experiences of female graduate students in counseling and clinical doctoral programs. Specifically, the study investigated achievement motivation, career role salience, consideration for future family and partner, and social support as predictors of leadership and career aspirations. Two hundred and two female graduate students in either counseling or clinical Ph.D. programs were sampled. Results indicated that achievement motivation, specifically the desire to work hard, was the most important predictor of career and leadership aspirations, and was the only consistent predictor across different types of aspirations. Additionally, work role salience contributed to the prediction of career-related aspirations. Last, differences emerged among women who were in the early years of their graduate program versus those in the later years of doctoral study. These findings could contribute to the literature on womens career decision making and have implications for practice and research

Engineering of flavin-binding proteins for superresolution and bioluminescence microscopy

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What is public relations to society? Toward an economically informed understanding of public relations

The notion of public relations contributing to the fabric of society is heavily contested in the public sphere and under-researched by the academy. The authors of this paper propose that the study of the relevance of public relations to society can be enlightened by turning to economics. Using information asymmetry as a framework, the argument is that public relations can be analyzed as a social institution that both helps to mitigate market imperfections and consequently increases the efficiency with which society’s resources are allocated as well as the chances for more market participants to derive value out of economic transaction

What is public relations to society? Toward an economically informed understanding of public relations

The notion of public relations contributing to the fabric of society is heavily contested in the public sphere and under-researched by the academy. The authors of this paper propose that the study of the relevance of public relations to society can be enlightened by turning to economics. Using information asymmetry as a framework, the argument is that public relations can be analyzed as a social institution that both helps to mitigate market imperfections and consequently increases the efficiency with which society’s resources are allocated as well as the chances for more market participants to derive value out of economic transaction

De novo missense variants in FBXO11 alter its protein expression and subcellular localization

Recently, others and we identified de novo FBXO11 (F-Box only protein 11) variants as causative for a variable neurodevelopmental disorder (NDD). We now assembled clinical and mutational information on 23 additional individuals. The phenotypic spectrum remains highly variable, with developmental delay and/or intellectual disability as the core feature and behavioral anomalies, hypotonia and various facial dysmorphism as frequent aspects. The mutational spectrum includes intragenic deletions, likely gene disrupting and missense variants distributed across the protein. To further characterize the functional consequences of FBXO11 missense variants, we analyzed their effects on protein expression and localization by overexpression of 17 different mutant constructs in HEK293 and HeLa cells. We found that the majority of missense variants resulted in subcellular mislocalization and/or reduced FBXO11 protein expression levels. For instance, variants located in the nuclear localization signal and the N-terminal F-Box domain lead to altered subcellular localization with exclusion from the nucleus or the formation of cytoplasmic aggregates and to reduced protein levels in western blot. In contrast, variants localized in the C-terminal Zn-finger UBR domain lead to an accumulation in the cytoplasm without alteration of protein levels. Together with the mutational data, our functional results suggest that most missense variants likely lead to a loss of the original FBXO11 function and thereby highlight haploinsufficiency as the most likely disease mechanism for FBXO11-associated NDDs

Kinetics of Palladium(0)‐Allyl Interactions in the Tsuji‐Trost Reaction, derived from Single‐Molecule Fluorescence Microscopy

Single‐molecule (SM) chemistry is devoted to unravel reaction steps which are hidden in cuvette experiments. Controversies about the substrate activation during the Tsuji‐Trost deallylation motivated us to study, on the single‐molecule level, the kinetics of the catalyst precursor Pd(PPh3)4 with our recently designed two‐color fluorescent probes. Photochemical, metal‐free bypass reactions were found and taken into account by the combination of spectrally separated single‐molecule TIRF‐microscopy and state‐of‐the art analysis procedures. Unselective π‐complex formation (KD≈103 M−1) precedes the insertion of the active catalyst into the C−OR bond (RO−=leaving group), indicated by the lacking immediate change of fluorescence color. The formed intermediate then decomposes on a time scale of≥2 – 3 s to the deallylated product

Progress Report on pH-Influenced Photocatalysis for Active Motion

Living systems use catalysis to achieve chemical transformations to comply with their needs in terms of energy and building blocks. The pH is a powerful means to regulate such processes, which also influences synthetic systems. In fact, the pH sensitivity of artificial photocatalysts, such as bismuth vanadate, bears the strong potential of flexibly influencing both the motion pattern and the speed of catalytic microswimmers, but it has rarely been investigated to date. In this work, we first present a comprehensive view of the motion behavior of differently shaped bismuth vanadate microswimmers, discuss influences, such as shape, pH, and conductivity of the solutions, and find that the motion pattern of the swimmers switches between upright and horizontal at their point of zero charge. We then apply an immobilizable hydroxypyrene derivative to our substrates to locally influence the pH of the solution by excited-state proton transfer. We find that the motion pattern of our swimmers is strongly influenced by this functionalization and a third motion mode, called tumbling, is introduced. Taking other effects, such as an increased surface roughness of the modified substrates, into account, we critically discuss possible future developments

Understanding public relations in the ‘sharing economy’

In spite of the macro-economic impact of the so-called ‘sharing economy’ there is a nearly complete dearth of contributions from the communication academy to its discourse. More attention is overdue, particularly for the conceptual pressure the ‘sharing economy’ is exerting on the public relations function. The authors propose a reconceptualization of public relations by identifying the constitutive aspects of the sharing economy and bringing together the explanatory concepts ‘circuits of commerce’ and ‘viable matches’ from economic sociology and communicative constitution of organizations theory to develop the notions of ‘deliberate disintermediation’ and ‘circuits of communication’ in public relations. The contention is that by doing this, communicative acts not only contribute meaning in the sharing economy, but have economic value. Furthermore, the sharing economy poses challenges to the traditional forms of organizing public relations functions, but offers opportunities to realize different potential when public relations facilitates circuits of communication and becomes a meta-communicative competence embedded within the organization