Older people's experiences of changed medication appearance : a survey

This report details a survey of older people's experiences of changed medication appearance. The aims of the study were: • To develop a questionnaire in partnership with older people to survey older people’s views on fluctuating medication appearance • To elicit older people’s experiences of medication that changed appearance due to ‘generic prescribing’ and ‘parallel import’ practices and its impact on their medication taking practices. These common pharmacy practices mean that the same tablet medication can be issued to older people in different colours, sizes and shapes to their previous prescriptions. Older people from a local User/Carer Forum highlighted these problems to the research team and asked that we investigate to explore the extent of the problem. An eight-item questionnaire was developed and distributed to 2000 older people (50 years+) across participating PCTs in Greater Manchester in 2008. A 29% response rate was achieved. The data was analysed using the SPSS statistical package. Findings include: •63.3% experienced a change in the appearance of their tablet medications. •74.1% did not seek advice regarding the change in the appearance of their tablet medications. •Older people noted changes to the actual tablets, tablet packaging and written information that accompanies tablets. Changes are occurring to the colour, size and shape of tablets more than changes to packaging and written information. The majority of respondents had experienced changes in the appearance of their prescribed tablet medication in the previous two years which were not due to change in medication or dose etc. Worryingly, for some respondents, these changes prompted negative experiences such as anxiety, confusion and upset. Of particular concern was that a small number omitted the affected tablet medications and did not seek help or advice from GPs, pharmacists or relatives. Six older people have been study advisors from inception to dissemination of this study and significantly added to its quality. The study demonstrates substantive public engagement / user involvement in research. The findings suggest nurses and others have a role to play in promoting better medicines management and identifying those most at risk from changed appearance of medications

Oceanographic Profiling and Spectroradiometer Observations from the MOCE-1 Cruise: 28 August to 8 October 1992

This report contains the frrst observations made for the Modis Optical Characterization Experiment (MOCE). Data presented here were obtained on the R/V DeSteiguer between 28 August and 8 October along the central California coast and in Monterey Bay. Three types of data are reported here: high spectral resolution radiometry at three depths for seven stations; salinity, temperature, fluorescence and beam attenuation profiles at the same stations; and total suspended matter and suspended organic carbon and nitrogen. [PDF contans 164 pages

Hall effect encoding of brushless dc motors

Encoding mechanism integral to the motor and using the permanent magnets embedded in the rotor eliminates the need for external devices to encode information relating the position and velocity of the rotating member

Comparing Infrared Dirac-Born-Infeld Brane Inflation to Observations

We compare the Infrared Dirac-Born-Infeld (IR DBI) brane inflation model to observations using a Bayesian analysis. The current data cannot distinguish it from the \LambdaCDM model, but is able to give interesting constraints on various microscopic parameters including the mass of the brane moduli potential, the fundamental string scale, the charge or warp factor of throats, and the number of the mobile branes. We quantify some distinctive testable predictions with stringy signatures, such as the large non-Gaussianity, and the large, but regional, running of the spectral index. These results illustrate how we may be able to probe aspects of string theory using cosmological observations.Comment: 54 pages, 13 figures. v2: non-Gaussianity constraint has been applied to the model; parameter constraints have tightened significantly, conclusions unchanged. References added; v3, minor revision, PRD versio

A likely role for anoxygenic photosynthetic microbes in the formation of ancient stromatolites

Although cyanobacteria are the dominant primary producers in modern stromatolites and other microbialites, the oldest stromatolites pre-date geochemical evidence for oxygenic photosynthesis and cyanobacteria in the rock record. As a step towards the development of laboratory models of stromatolite growth, we tested the potential of a metabolically ancient anoxygenic photosynthetic bacterium to build stromatolites. This organism, Rhodopseudomonas palustris, stimulates the precipitation of calcite in solutions already highly saturated with respect to calcium carbonate, and greatly facilitates the incorporation of carbonate grains into proto-lamina (i.e. crusts). The appreciable stimulation of the growth of proto-lamina by a nonfilamentous anoxygenic microbe suggests that similar microbes may have played a greater role in the formation of Archean stromatolites than previously assumed

Advanced propellant management system for spacecraft propulsion systems. Phase 1 - Survey study and evaluation

Apollo spacecraft propulsion system propellant managemen

The Number of States of Two Dimensional Critical String Theory

We discuss string theory vacua which have the wrong number of spacetime dimensions, and give a crude argument that vacua with more than four large dimensions are improbable. We then turn to two dimensional vacua, which naively appear to violate Bekenstein's entropy principle. A classical analysis shows that the naive perturbative counting of states is unjustified. All excited states of the system have strong coupling singularities which prevent us from concluding that they really exist. A speculative interpretation of the classical solutions suggests only a finite number of states will be found in regions bounded by a finite area. We also argue that the vacuum degeneracy of two dimensional classical string theory is removed in quantum mechanics. The system appears to be in a Kosterlitz-Thouless phase. This leads to the conclusion that it is also improbable to have only two large spacetime dimensions in string theory. However, we note that, unlike our argument for high dimensions, our conclusions about the ground state have neglected two dimensional quantum gravitational effects, and are at best incomplete.Comment: 12 pages, harvma

Winds as the origin of radio emission in z=2.5z=2.5 radio-quiet extremely red quasars

Most active galactic nuclei (AGNs) are radio-quiet, and the origin of their radio emission is not well-understood. One hypothesis is that this radio emission is a by-product of quasar-driven winds. In this paper, we present the radio properties of 108 extremely red quasars (ERQs) at $z=2-4$. ERQs are among the most luminous quasars ($L_{bol} \sim 10^{47-48}$ erg/s) in the Universe, with signatures of extreme ($\gg 1000$ km/s) outflows in their [OIII]$\lambda$5007 \AA\ emission, making them the best subjects to seek the connection between radio and outflow activity. All ERQs but one are unresolved in the radio on $\sim 10$ kpc scales, and the median radio luminosity of ERQs is $\nu L_\nu [{\rm 6\,GHz}] = 10^{41.0}$ erg/s, in the radio-quiet regime, but one to two orders of magnitude higher than that of other quasar samples. The radio spectra are steep, with a mean spectral index $\langle \alpha \rangle = -1.0$. In addition, ERQs neatly follow the extrapolation of the low-redshift correlation between radio luminosity and the velocity dispersion of [OIII]-emitting ionized gas. Uncollimated winds, with a power of one per cent of the bolometric luminosity, can account for all these observations. Such winds would interact with and shock the gas around the quasar and in the host galaxy, resulting in acceleration of relativistic particles and the consequent synchrotron emission observed in the radio. Our observations support the picture in which ERQs are signposts of extremely powerful episodes of quasar feedback, and quasar-driven winds as a contributor of the radio emission in the intermediate regime of radio luminosity $\nu L_\nu = 10^{39}-10^{42}$ erg/s.Comment: accepted by MNRA

Active Galactic Nuclei with Candidate Intermediate-Mass Black Holes

We present an initial sample of 19 intermediate-mass black hole candidates in active galactic nuclei culled from the First Data Release of the Sloan Digital Sky Survey. Using the linewidth-luminosity-mass scaling relation established for broad-line active nuclei, we estimate black hole masses in the range of 8 x 10^4 - 10^6 solar masses, a regime in which only two objects are currently known. The absolute magnitudes are faint for active galactic nuclei, ranging from M_g of -15 to -18 mag, while the bolometric luminosities are all close to the Eddington limit. The entire sample formally satisfies the linewidth criterion for so-called narrow-line Seyfert 1 galaxies; however, they display a wider range of FeII and [OIII] (5007) line strengths than is typically observed in this class of objects. Although the available imaging data are of insufficient quality to ascertain the detailed morphologies of the host galaxies, it is likely that the majority of the hosts are relatively late-type systems. The host galaxies have estimated g-band luminosities ~ 1 mag fainter than M* for the general galaxy population at z of 0.1. Beyond simply extending the known mass range of central black holes in galactic nuclei, these objects provide unique observational constraints on the progenitors of supermassive black holes. They are also expected to contribute significantly to the integrated signal for future gravitational wave experiments.Comment: ApJ Accepted, 13 pages, 9 figures, uses emulateapj.cl