ADP correspondence system: Unsolicited proposal evaluation tracking application

A complete description of a correspondence control system, designed to be used by non-ADP clerical personnel is provided. In addition to operating instructions, sufficient design and conceptual information is provided to allow use or adaption of the system in related applications. The complete COBOL program and documentation are available

On the Theory of Fermionic Preheating

In inflationary cosmology, the particles constituting the Universe are created after inflation due to their interaction with moving inflaton field(s) in the process of preheating. In the fermionic sector, the leading channel is out-of equilibrium particle production in the non-perturbative regime of parametric excitation, which respects Pauli blocking but differs significantly from the perturbative expectation. We develop theory of fermionic preheating coupling to the inflaton, without and with expansion of the universe, for light and massive fermions, to calculate analytically the occupation number of created fermions, focusing on their spectra and time evolution. In the case of large resonant parameter $q$ we extend for rermions the method of successive parabolic scattering, earlier developed for bosonic preheating. In an expanding universe parametric excitation of fermions is stochastic. Created fermions very quickly, within tens of inflaton oscillations, fill up a sphere of radius $\simeq q^{1/4}$ in monetum space. We extend our formalism to the production of superheavy fermions and to `instant' fermion creation.Comment: 14 pages, latex, 12 figures, submitted for publicatio

The Development of Equilibrium After Preheating

We present a fully nonlinear study of the development of equilibrium after preheating. Preheating is the exponentially rapid transfer of energy from the nearly homogeneous inflaton field to fluctuations of other fields and/or the inflaton itself. This rapid transfer leaves these fields in a highly nonthermal state with energy concentrated in infrared modes. We have performed lattice simulations of the evolution of interacting scalar fields during and after preheating for a variety of inflationary models. We have formulated a set of generic rules that govern the thermalization process in all of these models. Notably, we see that once one of the fields is amplified through parametric resonance or other mechanisms it rapidly excites other coupled fields to exponentially large occupation numbers. These fields quickly acquire nearly thermal spectra in the infrared, which gradually propagates into higher momenta. Prior to the formation of total equilibrium, the excited fields group into subsets with almost identical characteristics (e.g. group effective temperature). The way fields form into these groups and the properties of the groups depend on the couplings between them. We also studied the onset of chaos after preheating by calculating the Lyapunov exponent of the scalar fields.Comment: 15 pages, 23 figure

The Saccharomyces cerevisiae SEC14 Gene Encodes a Cytosolic Factor That Is Required for Transport of Secretory Proteins from the Yeast Golgi Complex

We have obtained and characterized a genomic clone of SEC14, a Saccharomyces cerevisiae gene whose product is required for export of yeast secretory proteins from the Golgi complex. Gene disruption experiments indicated that SEC14 is an essential gene for yeast vegetative growth. Nucleotide sequence analysis revealed the presence of an intron within the SEC14 structural gene, and predicted the synthesis of a hydrophilic polypeptide of 35 kD in molecular mass. In confirmation, immunoprecipitation experiments demonstrated SEC14p to be an unglycosylated polypeptide, with an apparent molecular mass of some 37 kD, that behaved predominantly as a cytosolic protein in subcellular fractionation experiments. These data were consistent with the notion that SEC14p is a cytosolic factor that promotes protein export from yeast Golgi. Additional radiolabeling experiments also revealed the presence of SEC14p-related polypeptides in extracts prepared from the yeasts Kluyveromyces lactis and Schizosaccharomyces pombe. Furthermore, the K. lactis SEC14p was able to functionally complement S. cerevisiae sec14ts defects. These data suggested a degree of conservation of SEC14p structure and function in these yeasts species

Andreev Reflection in Heavy-Fermion Superconductors and Order Parameter Symmetry in CeCoIn_5

Differential conductance spectra are obtained from nanoscale junctions on the heavy-fermion superconductor CeCoIn$_5$ along three major crystallographic orientations. Consistency and reproducibility of characteristic features among the junctions ensure their spectroscopic nature. All junctions show a similar conductance asymmetry and Andreev reflection-like conductance with reduced signal (~ 10%-13%), both commonly observed in heavy-fermion superconductor junctions. Analysis using the extended Blonder-Tinkham-Klapwijk model indicates that our data provide the first spectroscopic evidence for $d_{x^2-y^2}$ symmetry. To quantify our conductance spectra, we propose a model by considering the general phenomenology in heavy fermions, the two-fluid behavior, and an energy-dependent density of states. Our model fits to the experimental data remarkably well and should invigorate further investigations.Comment: 4 pages, 4 figures; Phys. Rev. Lett., published versio

Local tunneling spectroscopy of the electron-doped cuprate Sm1.85Ce0.15CuO4

We present local tunneling spectroscopy in the optimally electron-doped cuprate Sm2-xCexCuO4 x=0.15. A clear signature of the superconducting gap is observed with an amplitude ranging from place to place and from sample to sample (Delta~3.5-6meV). Another spectroscopic feature is simultaneously observed at high energy above \pm 50meV. Its energy scale and temperature evolution is found to be compatible with previous photoemission and optical experiments. If interpreted as the signature of antiferromagnetic order in the samples, these results could suggest the coexistence on the local scale of antiferromagnetism and superconductivity on the electron-doped side of cuprate superconductors

Dominant-negative ATF5 rapidly depletes survivin in tumor cells.

Survivin (BIRC5, product of the BIRC5 gene) is highly expressed in many tumor types and has been widely identified as a potential target for cancer therapy. However, effective anti-survivin drugs remain to be developed. Here we report that both vector-delivered and cell-penetrating dominant-negative (dn) forms of the transcription factor ATF5 that promote selective death of cancer cells in vitro and in vivo cause survivin depletion in tumor cell lines of varying origins. dn-ATF5 decreases levels of both survivin mRNA and protein. The depletion of survivin protein appears to be driven at least in part by enhanced proteasomal turnover and depletion of the deubiquitinase USP9X. Survivin loss is rapid and precedes the onset of cell death triggered by dn-ATF5. Although survivin downregulation is sufficient to drive tumor cell death, survivin over-expression does not rescue cancer cells from dn-ATF5-promoted apoptosis. This indicates that dn-ATF5 kills malignant cells by multiple mechanisms that include, but are not limited to, survivin depletion. Cell-penetrating forms of dn-ATF5 are currently being developed for potential therapeutic use and the present findings suggest that they may pose an advantage over treatments that target only survivin

SDSS J143030.22-001115.1: A misclassified narrow-line Seyfert 1 galaxy with flat X-ray spectrum

We used multi-component profiles to model H$\beta$ and [O III]$\lambda \lambda$4959,5007 lines for SDSS J143030.22-001115.1, a narrow-line Seyfert 1 galaxy (NLS1) in a sample of 150 NLS1s candidates selected from the Sloan Digital Sky Survey (SDSS) Early Data Release (EDR). After subtracting the H$\beta$ contribution from narrow line regions (NLRs), we found that its full width half maximum (FWHM) of broad H$\beta$ line is nearly 2900 \kms, significantly larger than the customarily adopted criterion of 2000 \kms. With its weak Fe II multiples, we think that SDSS J143030.22-001115.1 can't be classified as a genuine NLS1. When we calculate the virial black hole masses of NLS1s, we should use the H$\beta$ linewidth after subtracting the H$\beta$ contribution from NLRs.Comment: 7 pages, 1 table, accepted by ChJA