A computer program for plotting stress-strain data from compression, tension, and torsion tests of materials

A computer program for plotting stress-strain curves obtained from compression and tension tests on rectangular (flat) specimens and circular-cross-section specimens (rods and tubes) and both stress-strain and torque-twist curves obtained from torsion tests on tubes is presented in detail. The program is written in FORTRAN 4 language for the Control Data 6000 series digital computer with the SCOPE 3.0 operating system and requires approximately 110000 octal locations of core storage. The program has the capability of plotting individual strain-gage outputs and/or the average output of several strain gages and the capability of computing the slope of a straight line which provides a least-squares fit to a specified section of the plotted curve. In addition, the program can compute the slope of the stress-strain curve at any point along the curve. The computer program input and output for three sample problems are presented

Oral Dosages of the NSAID Aspirin Decreased the Growth Rate of Species Found in the Human Gut Microbiome Including Akkermansia muciniphila, Bacteroides fragilis, Clostridium sordellii, and Clostridium difficile

Over past few decades, new insight has been revealed in the scientific community about the importance of the human gut microbiome relating to general health. It is known that imbalances in the species that reside in the human gut can cause organism-wide problems in humans. When prescribing or injecting oral medications, the thought of the downstream effects on the gut microbiome are not always considered. By exposing known healthy members of the gut; Akkermansia muciniphila, Bacteroides fragilis, Clostridium sordellii, and Clostridium difficile to the Aspirin, this study attempted to provide insight into the effects of the drug on bacterial growth. While these species only account for a small percentage of the total biodiversity of the gut microbiome, they are some of the most thoroughly studied and well known. A. muciniphila is known to occur in higher concentrations in healthy, low body mass index individuals which suggests that aspirin alternatives may be beneficial in some clinical cases. To accomplish the goal of this study, time courses were designed to analyze if different dosages of Aspirin inhibited the growth curve of each species when compared to growth curves of the same species in drug-free media. Aspirin was found to have a dose-dependent effect in growth rate of A. muciniphila, B. fragilis, C. sordellii, and C. difficile resulting in a significant decrease in the exponential growth phase of all four species. This suggested that aspirin inhibited cell culture growth in a dose-dependent manner. Aspirin’s toxic affect to these important commensal species of the human gut should be considered by practitioners prior to prescription

Title III - Recalcitrant Witnesses

This title represents a congressional attempt to codify the court-developed civil contempt practice. When a witness is granted immunity and still refuses to answer the question presented to him he can be ordered by a court to answer the specific question. Upon his continued refusal, a court can have him confined summarily until he complies with such order, or until he is no longer able to comply. Such confinement is not intended to be punitive in nature, but rather to coerce compliance with the court\u27s order by imposing imprisonment as an alternative to answering the question. The witness will be released from confinement as soon as he is willing to obey the court order. Consequently, he is said to carry the keys of [his] prison in [his] own pockets. Since the confinement is based on the witness\u27 refusal to comply, however, he may not be jailed after it is impossible for him effectively to carry out the court\u27s order, i.e., after the relevant proceeding has terminated. As a result of the purpose of the confinement and its particular features, the remedy is considered civil in nature, and the witness is not entitled to the same procedural protections that are provided for the defendant accused of a criminal act. Thus, an indictment and jury trial are not within the due process requirements which must be afforded the recalcitrant witness

Title I - Special Grand Jury

Title I establishes special grand juries to sit in major population areas and other areas designated by the Attorney General. These grand juries are protected from arbitrary dismissal by the district court before completion of their work. They can sit for extended periods (a maximum of thirty-six months), and are authorized to issue reports concerning (a) noncriminal misconduct of appointed government officials or employees involving organized criminal activity; and (b) organized crime conditions within the district. When reports are issued concerning governmental misconduct, individuals named are given notice, afforded the opportunity to present evidence, file an answer, and obtain judicial review, all prior to publication. This title also amends the Jencks Act (18 U.S.C. § 3500) by including grand jury minutes in its definition of statements, and expanding its coverage to statements of prospective witnesses in the government\u27s possession regardless of their source

Title II - General Immunity

This title repeals or conforms the over fifty existing federal immunity statutes and establishes a uniform federal immunity statute to apply to proceedings before or ancillary to a court, grand jury, or agency of the United States, either house of Congress, or its joint committees, committees or subcommittees. The scope of immunity granted protects a witness from the use of his testimony or its fruits in a future criminal prosecution, but does not protect him from prosecution itself. This reflects a positive decision by Congress that the fifth amendment self-incrimination clause only requires a grant of what has been referred to as use or testimonial immunity rather than transactional immunity. Originally, this provision was promulgated to strengthen the evidence gathering process against organized crime: it applied only to court and grand jury proceedings. Subsequently, the recommendations of the National Commission on Reform of Federal Criminal Laws were adopted establishing a general federal immunity statute that applied to legislative and administrative proceedings as well as judicial proceedings

Title IV - False Declarations

Title IV was designed to facilitate the bringing of federal perjury prosecutions, thereby strengthening the deterrent value of the perjury penalties and acting as a greater incentive for truthful testimony. It establishes a new false declarations statute applicable to court and grand jury proceedings, with maximum penalty slightly increased over that allowable under the previously controlling perjury statute

Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of β-Cell Function in Therapeutic Trials in Type 1 Diabetes

OBJECTIVE—β-Cell function in type 1 diabetes clinical trials is commonly measured by C-peptide response to a secretagogue in either a mixed-meal tolerance test (MMTT) or a glucagon stimulation test (GST). The Type 1 Diabetes TrialNet Research Group and the European C-peptide Trial (ECPT) Study Group conducted parallel randomized studies to compare the sensitivity, reproducibility, and tolerability of these procedures