1,260 research outputs found
Risk factors for house-entry by malaria vectors in a rural town and satellite villages in The Gambia.
Background:
In the pre-intervention year of a randomized controlled trial investigating the protective effects of house screening against malaria-transmitting vectors, a multi-factorial risk factor analysis study was used to identify factors that influence mosquito house entry.
Methods:
Mosquitoes were sampled using CDC light traps in 976 houses, each on one night, in Farafenni town and surrounding villages during the malaria-transmission season in The Gambia. Catches from individual houses were both (a) left unadjusted and (b) adjusted relative to the number of mosquitoes caught in four sentinel houses that were operated nightly throughout the period, to allow for night-to-night variation. Houses were characterized by location, architecture, human occupancy and their mosquito control activities, and the number and type of domestic animals within the compound.
Results:
106,536 mosquitoes were caught, of which 55% were Anopheles gambiae sensu lato, the major malaria vectors in the region. There were seven fold higher numbers of An. gambiae s.l. in the villages (geometric mean per trap night = 43.7, 95% confidence intervals, CIs = 39.5–48.4) than in Farafenni town (6.3, 5.7–7.2) and significant variation between residential blocks (p < 0.001). A negative binomial multivariate model performed equally well using unadjusted or adjusted trap data. Using the unadjusted data the presence of nuisance mosquitoes was reduced if the house was located in the town (odds ratio, OR = 0.11, 95% CIs = 0.09–0.13), the eaves were closed (OR = 0.71, 0.60–0.85), a horse was tethered near the house (OR = 0.77, 0.73–0.82), and churai, a local incense, was burned in the room at night (OR = 0.56, 0.47–0.66). Mosquito numbers increased per additional person in the house (OR = 1.04, 1.02–1.06) or trapping room (OR = 1.19, 1.13–1.25) and when the walls were made of mud blocks compared with concrete (OR = 1.44, 1.10–1.87).
Conclusion:
This study demonstrates that the risk of malaria transmission is greatest in rural areas, where large numbers of people sleep in houses made of mud blocks, where the eaves are open, horses are not tethered nearby and where churai is not burnt at night. These factors need to be considered in the design and analysis of intervention studies designed to reduce malaria transmission in The Gambia and other parts of sub-Saharan Africa
Viability of primordial black holes as short period gamma-ray bursts
It has been proposed that the short period gamma-ray bursts, which occur at a
rate of , may be evaporating primordial black holes
(PBHs). Calculations of the present PBH evaporation rate have traditionally
assumed that the PBH mass function varies as . This mass
function only arises if the density perturbations from which the PBHs form have
a scale invariant power spectrum. It is now known that for a scale invariant
power spectrum, normalised to COBE on large scales, the PBH density is
completely negligible, so that this mass function is cosmologically irrelevant.
For non-scale-invariant power spectra, if all PBHs which form at given epoch
have a fixed mass then the PBH mass function is sharply peaked around that
mass, whilst if the PBH mass depends on the size of the density perturbation
from which it forms, as is expected when critical phenomena are taken into
account, then the PBH mass function will be far broader than . In this paper we calculate the present day PBH evaporation rate,
using constraints from the diffuse gamma-ray background, for both of these mass
functions. If the PBH mass function has significant finite width, as recent
numerical simulations suggest, then it is not possible to produce a present day
PBH evaporation rate comparable with the observed short period gamma-ray burst
rate. This could also have implications for other attempts to detect
evaporating PBHs.Comment: 5 pages, 2 figures, version to appear in Phys. Rev. D with additional
reference
Bounds on the cosmological abundance of primordial black holes from diffuse sky brightness: single mass spectra
We constrain the mass abundance of unclustered primordial black holes (PBHs),
formed with a simple mass distribution and subject to the Hawking evaporation
and particle absorption from the environment. Since the radiative flux is
proportional to the numerical density, an upper bound is obtained by comparing
the calculated and observed diffuse background values, (similarly to the Olbers
paradox in which point sources are considered) for finite bandwidths. For a
significative range of formation redshifts the bounds are better than several
values obtained by other arguments ; and they apply
to PBHs which are evaporating today.Comment: 20 pages, 5 figures, to appear in PR
The issue of Dark Energy in String Theory
Recent astrophysical observations, pertaining to either high-redshift
supernovae or cosmic microwave background temperature fluctuations, as those
measured recently by the WMAP satellite, provide us with data of unprecedented
accuracy, pointing towards two (related) facts: (i) our Universe is accelerated
at present, and (ii) more than 70 % of its energy content consists of an
unknown substance, termed dark energy, which is believed responsible for its
current acceleration. Both of these facts are a challenge to String theory. In
this review I outline briefly the challenges, the problems and possible avenues
for research towards a resolution of the Dark Energy issue in string theory.Comment: Based on Invited lecture at the ``Third Aegean Summer School on: The
Invisible Universe: Dark matter and Dark energy'', Karfas, Chios Island
(Greece) September 26-October 1 200
Comment about UV regularization of basic commutators in string theories
Recently proposed by Hwang, Marnelius and Saltsidis zeta regularization of
basic commutators in string theories is generalized to the string models with
non-trivial vacuums. It is shown that implementation of this regularization
implies the cancellation of dangerous terms in the commutators between Virasoro
generators, which break Jacobi identity.Comment: LaTeX, 9 pages, no figures, submitted to Physics Letters
Entropy of Lovelock Black Holes
A general formula for the entropy of stationary black holes in Lovelock
gravity theories is obtained by integrating the first law of black hole
mechanics, which is derived by Hamiltonian methods. The entropy is not simply
one quarter of the surface area of the horizon, but also includes a sum of
intrinsic curvature invariants integrated over a cross section of the horizon.Comment: 15 pages, plain Latex, NSF-ITP-93-4
Oxygen mapping of melanoma spheroids using small molecule platinum probe and phosphorescence lifetime imaging microscopy
Solid tumours display varied oxygen levels and this characteristic can be exploited to develop new diagnostic tools to determine and exploit these variations. Oxygen is an efficient quencher of emission of many phosphorescent compounds, thus oxygen concentration could in many cases be derived directly from relative emission intensity and lifetime. In this study, we extend our previous work on phosphorescent, low molecular weight platinum(II) complex as an oxygen sensing probe to study the variation in oxygen concentration in a viable multicellular 3D human tumour model. The data shows one of the first examples of non-invasive, real-time oxygen mapping across a melanoma tumour spheroid using one-photon phosphorescence lifetime imaging microscopy (PLIM) and a small molecule oxygen sensitive probe. These measurements were quantitative and enabled real time oxygen mapping with high spatial resolution. This combination presents as a valuable tool for optical detection of both physiological and pathological oxygen levels in a live tissue mass and we suggest has the potential for broader clinical application
Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial
Background: House screening should protect people against malaria. We assessed whether two types of house screening—full screening of windows, doors, and closing eaves, or installation of screened ceilings—could reduce house entry of malaria vectors and frequency of anaemia in children in an area of seasonal malaria transmission. Methods: During 2006 and 2007, 500 occupied houses in and near Farafenni town in The Gambia, an area with low use of insecticide-treated bednets, were randomly assigned to receive full screening, screened ceilings, or no screening (control). Randomisation was done by computer-generated list, in permuted blocks of five houses in the ratio 2:2:1. Screening was not treated with insecticide. Exposure to mosquitoes indoors was assessed by fortnightly light trap collections during the transmission season. Primary endpoints included the number of female Anopheles gambiae sensu lato mosquitoes collected per trap per night. Secondary endpoints included frequency of anaemia (haemoglobin concentration <80 g/L) and parasitaemia at the end of the transmission season in children (aged 6 months to 10 years) who were living in the study houses. Analysis was by modified intention to treat (ITT), including all randomised houses for which there were some outcome data and all children from those houses who were sampled for haemoglobin and parasitaemia. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN51184253. Findings: 462 houses were included in the modified ITT analysis (full screening, n=188; screened ceilings, n=178; control, n=96). The mean number of A gambiae caught in houses without screening was 37·5 per trap per night (95% CI 31·6–43·3), compared with 15·2 (12·9–17·4) in houses with full screening (ratio of means 0·41, 95% CI 0·31–0·54; p<0·0001) and 19·1 (16·1–22·1) in houses with screened ceilings (ratio 0·53, 0·40–0·70; p<0·0001). 755 children completed the study, of whom 731 had complete clinical and covariate data and were used in the analysis of clinical outcomes. 30 (19%) of 158 children from control houses had anaemia, compared with 38 (12%) of 309 from houses with full screening (adjusted odds ratio [OR] 0·53, 95% CI 0·29–0·97; p=0·04), and 31 (12%) of 264 from houses with screened ceilings (OR 0·51, 0·27–0·96; p=0·04). Frequency of parasitaemia did not differ between intervention and control groups. Interpretation: House screening substantially reduced the number of mosquitoes inside houses and could contribute to prevention of anaemia in children
DNA hybridization catalysts and catalyst circuits
Practically all of life's molecular processes, from chemical synthesis to replication, involve enzymes that carry out their functions through the catalysis of metastable fuels into waste products. Catalytic control of reaction rates will prove to be as useful and ubiquitous in
DNA nanotechnology as it is in biology. Here we present experimental results on the control of the decay rates of a metastable DNA "fuel". We show that the fuel complex can be induced to decay with a rate about 1600 times faster than it would decay spontaneously. The original DNA hybridization catalyst [15] achieved a maximal speed-up of roughly 30. The fuel complex discussed here can therefore serve as the basic ingredient for an improved DNA hybridization catalyst. As an example application for DNA hybridization catalysts, we propose a method for implementing arbitrary digital logic circuits
Remarks on self-interaction correction to black hole radiation
In the work [P. Kraus and F. Wilczek, \textit{Self-interaction correction to
black hole radiation, Nucl. Phys.} B433 (1995) 403], it has been pointed out
that the self-gravitation interaction would modify the black hole radiation so
that it is no longer thermal, where it is, however, corrected in an approximate
way and therefore is not established its relationship with the underlying
unitary theory in quantum theory. In this paper, we revisit the
self-gravitation interaction to Hawking radiation of the general spherically
symmetric black hole, and find that the precisely derived spectrum is not only
deviated from the purely thermal spectrum, but most importantly, is related to
the change of the Bekenstein-Hawking entropy and consistent with an underlying
unitary theory.Comment: 14 page
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