4,842 research outputs found
Architectures for vibration-driven micropower generators
Published versio
Recommended from our members
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radiotherapy-induced DNA double strand breaks (DSB) are critical cytotoxic lesions. Inherited defects in DSB DNA repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence. A patient with xeroderma pigmentosum complementation group C, with a scalp angiosarcoma exhibited dramatic clinical radiosensitivity following radiotherapy, resulting in death. A fibroblast cell line from non-affected skin (XP14BRneo17) was hypersensitive to ionising radiation and defective in DNA double strand break repair.
Aim: To determine the genetic defect causing cellular radiation hypersensitivity in XP14BRneo17 cells.
Methods: Functional genetic complementation whereby copies of human chromosomes containing genes involved in DNA DSB repair (chromosomes 2, 5, 8 10, 13 and 22) were individually transferred to XP14BRneo17 cells in an attempt to correct the radiation hypersensitivity. Clonogenic survival assays and γ-H2AX immunofluorescence were conducted to measure radiation sensitivity and repair of DNA DSBs. DNA sequencing of defective DNA repair genes was performed.
Results: Transfer of chromosome 8 (location of DNA-PKcs gene), and transfection of a mammalian expression construct containing the DNA-PKcs cDNA restored normal ionising radiation sensitivity and repair of DNA DSBs in XP14BRneo17 cells. DNA sequencing of the DNA-PKcs coding region revealed a 249 bp deletion (between base pairs 3656-3904) encompassing exon 31 of the gene.
Conclusion: We provide evidence of a novel splice variant of the DNA-PKcs gene associated with radiosensitivity in a xeroderma pigmentosum patient and report the first double mutant in distinct DNA repair pathways being consistent with viability.Brunel Open Access Publishing Fun
Micro-machined variable capacitors for power generation
Accepted versio
Supporting Big Data Research at Case Western Reserve University
This report is an investigation of the research practices of faculty and research staff who utilize or support data science or big data methodologies at Case Western Reserve University (CWRU). The study was conducted by librarians and library staff within the Kelvin Smith Library (KSL) in collaboration with staff within CWRU University Technology ([U]tech), and was part of national selection of parallel studies occurring at public and private academic institutions throughout North America
Tests of the Gravitational Inverse-Square Law
We review recent experimental tests of the gravitational inverse-square law
and the wide variety of theoretical considerations that suggest the law may
break down in experimentally accessible regions.Comment: 81 pages, 10 figures, submitted by permission of the Annual Review of
Nuclear and Particle Science. Final version of this material is scheduled to
appear in the Annual Review of Nuclear and Particle Science Vol. 53, to be
published in December 2003 by Annual Reviews, http://AnnualReviews.or
Online social networking: Relationship marketing in UK hotels
The role and the existing and potential use of online social networking as a relationship marketing (RM) tool is evaluated in the context of luxury hotels. Semi-structured interviews were conducted with the persons responsible for the management of social networking in 10 luxury hotels. Constant comparative analysis, applied within a codebook framework, revealed online social networks (OSNs) provided RM opportunities and increased business value. It is acknowledged that the full potential of OSNs has yet to be realised in terms of hotel marketing. Opportunities for extending the utilisation of OSNs are identified alongside recommendations for hotel marketing practitioners with regard to addressing consumers' needs, and areas for further research are outlined. © 2013 Copyright 2013 Westburn Publishers Ltd
Finite Schur filtration dimension for modules over an algebra with Schur filtration
Let G be GL_N or SL_N as reductive linear algebraic group over a field k of
positive characteristic p. We prove several results that were previously
established only when N 2^N. Let G act rationally on a finitely
generated commutative k-algebra A. Assume that A as a G-module has a good
filtration or a Schur filtration. Let M be a noetherian A-module with
compatible G action. Then M has finite good/Schur filtration dimension, so that
there are at most finitely many nonzero H^i(G,M). Moreover these H^i(G,M) are
noetherian modules over the ring of invariants A^G. Our main tool is a
resolution involving Schur functors of the ideal of the diagonal in a product
of Grassmannians.Comment: 22 pages; final versio
10C continued: A deeper radio survey at 15.7 GHz
We present deep 15.7-GHz observations made with the Arcminute Microkelvin
Imager Large Array in two fields previously observed as part of the Tenth
Cambridge (10C) survey. These observations allow the source counts to be
calculated down to 0.1 mJy, a factor of five deeper than achieved by the 10C
survey. The new source counts are consistent with the extrapolated fit to the
10C source count, and display no evidence for either steepening or flattening
of the counts. There is thus no evidence for the emergence of a significant new
population of sources (e.g. starforming) at 15.7 GHz flux densities above 0.1
mJy, the flux density level at which we expect starforming galaxies to begin to
contribute. Comparisons with the de Zotti et al. model and the SKADS Simulated
Sky show that they both underestimate the observed number of sources by a
factor of two at this flux density level. We suggest that this is due to the
flat-spectrum cores of radio galaxies contributing more significantly to the
counts than predicted by the models.We thank the staff of the Mullard Radio Astronomy Observatory for maintaining and operating AMI. IHW and CR acknowledge Science and Technology Facilities Council studentships. IHW acknowledges support from the Square Kilometre Array South Africa project and the South African National Research Foundation. This research has made use of NASA’s Astrophysics Data System. We thank the referee for their careful reading of this manuscript.This is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/mnras/stv296
- …