From bedside to bench: Comroe and dripps revisited

Twenty-five years ago a paper published in Science by Julius Comroe and Robert Dripps purported to demonstrate that 41 per cent of all articles judged to be essential for later clinical advances were not clinically oriented at the time of the study and 62 per cent of key articles were the result of basic research. Since that analysis, support for basic research has increased in the G7 countries. In the UK, Research Council expenditure on basic research has increased from a low of £444 million (or 42 per cent of total civil R&D) in 1991/92 to £769 million (or 61 per cent of total civil R&D) in 1998/99. Although it would be difficult to argue that Comroe and Dripps were directly responsible for a strategic shift (or drift) in the type of science supported by research funders, their arguments are often cited (albeit at times implicitly) in support of the increased funding for basic biomedical research. In 1987 Richard Smith wrote a critical paper reassessing Comroe and Dripps. His main argument was that the original study was in itself ‘unscientific’ and that it should be “followed by bigger and better studies”. This study is, in part, an answer to that challenge. Given the increased support for basic research, and the apparent importance based on the work of Comroe and Dripps, we felt it was important to investigate Smith’s comments by replicating Comroe and Dripps’s study and at the same time try to improve upon the methodology. The current project had two objectives: 1. To see if the original Comroe and Dripps’s methodology was ‘replicable’. 2. To validate the key findings of Comroe and Dripps. By looking at neonatal intensive care (NIC), we concluded that Comroe and Dripps’ study – as reported – is not repeatable, reliable or valid, and thus is an insufficient evidence base for increased expenditure on basic biomedical research. We did, however, develop an alternative methodology which used bibliographic databases and bibliometric techniques to describe the research underpinning five of the most important clinical advances in NIC, as identified through a Delphi survey. Using the revised bibliometric protocol, we demonstrated that after a time-lag of about 17 years, between 2 and 21 per cent of research underpinning the clinical advances could be described as basic. This observation is at odds with Comroe and Dripps’s finding that 62 per cent of key research articles judged to be essential for latter clinical advance were the result of basic research. In reaching this conclusion we are acutely aware of the significant limitations to the revised methodology and, therefore, we caution against the over-interpretation of our results. However, we would argue that there needs to be a greater understanding of how basic research supports healthcare and hope this report will inform part of this wider debate.R&D Directorate of the NHS Executive London; Wellcome Trus

On Artin algebras arising from Morita contexts

We study Morita rings \Lambda_{(\phi,\psi)}=\bigl({smallmatrix} A &_AN_B_BM_A & B {smallmatrix}\bigr) in the context of Artin algebras from various perspectives. First we study covariant finite, contravariant finite, and functorially finite subcategories of the module category of a Morita ring when the bimodule homomorphisms $\phi$ and $\psi$ are zero. Further we give bounds for the global dimension of a Morita ring $\Lambda_{(0,0)}$, regarded as an Artin algebra, in terms of the global dimensions of $A$ and $B$ in the case when both $\phi$ and $\psi$ are zero. We illustrate our bounds with some examples. Finally we investigate when a Morita ring is a Gorenstein Artin algebra and then we determine all the Gorenstein-projective modules over the Morita ring with $A=N=M=B=\Lambda$, where $\Lambda$ is an Artin algebra.Comment: 29 pages, revised versio

Instrument quickly transposes ground reference target to eye level

Optical alignment of equipment is facilitated by a traverse target with a string suspending a plumb bob to transpose the ground level point to eye level operation. This instrument appreciably decreases the time required from the present method but achieves the same degree of precision

Electron paramagnetic resonance and photochromism of N3V0\mathrm{N}_{3}\mathrm{V}^{0} in diamond

The defect in diamond formed by a vacancy surrounded by three nearest-neighbor nitrogen atoms and one carbon atom, $\mathrm{N}_{3}\mathrm{V}$, is found in $\approx98\%$ of natural diamonds. Despite $\mathrm{N}_{3}\mathrm{V}^{0}$ being the earliest electron paramagnetic resonance spectrum observed in diamond, to date no satisfactory simulation of the spectrum for an arbitrary magnetic field direction has been produced due to its complexity. In this work, $\mathrm{N}_{3}\mathrm{V}^{0}$ is identified in $^{15}\mathrm{N}$-doped synthetic diamond following irradiation and annealing. The $\mathrm{^{15}N}_{3}\mathrm{V}^{0}$ spin Hamiltonian parameters are revised and used to refine the parameters for $\mathrm{^{14}N}_{3}\mathrm{V}^{0}$, enabling the latter to be accurately simulated and fitted for an arbitrary magnetic field direction. Study of $\mathrm{^{15}N}_{3}\mathrm{V}^{0}$ under excitation with green light indicates charge transfer between $\mathrm{N}_{3}\mathrm{V}$ and $\mathrm{N_s}$. It is argued that this charge transfer is facilitated by direct ionization of $\mathrm{N}_{3}\mathrm{V}^{-}$, an as-yet unobserved charge state of $\mathrm{N}_{3}\mathrm{V}$

Maximal supersymmetry and exceptional groups

The article is a tribute to my old mentor, collaborator and friend Murray Gell-Mann. In it I describe work by Pierre Ramond, Sung-Soo Kim and myself where we describe the N = 8 Supergravity in the light-cone formalism. We show how the Cremmer-Julia E7(7) non-linear symmetry is implemented and how the full supermultiplet is a representation of the E7(7) symmetry. I also show how the E7(7) symmetry is a key to understand the higher order couplings in the theory and is very useful when we discuss possible counterterms for this theory.Comment: Proceedings of Conference in Honour of Murray Gell-Mann's 80th Birthda

String Bit Models for Superstring

We extend the model of string as a polymer of string bits to the case of superstring. We mainly concentrate on type II-B superstring, with some discussion of the obstacles presented by not II-B superstring, together with possible strategies for surmounting them. As with previous work on bosonic string we work within the light-cone gauge. The bit model possesses a good deal less symmetry than the continuous string theory. For one thing, the bit model is formulated as a Galilei invariant theory in $(D-2)+1$ dimensional space-time. This means that Poincar\'e invariance is reduced to the Galilei subgroup in $D-2$ space dimensions. Naturally the supersymmetry present in the bit model is likewise dramatically reduced. Continuous string can arise in the bit models with the formation of infinitely long polymers of string bits. Under the right circumstances (at the critical dimension) these polymers can behave as string moving in $D$ dimensional space-time enjoying the full $N=2$ Poincar\'e supersymmetric dynamics of type II-B superstring.Comment: 43 pages, phyzzx require

The Standard Model on a D-brane

We present a consistent string theory model which reproduces the Standard Model, consisting of a D3-brane at a simple orbifold singularity. We study some simple features of the phenomenology of the model. We find that the scale of stringy physics must be in the multi-TeV range. There are natural hierarchies in the fermion spectrum and there are several possible experimental signatures of the model.Comment: 8 pages Latex, 1 fig. v2: discussion improved, added new reference

Perturbative Relations between Gravity and Gauge Theory

We review the relations that have been found between multi-loop scattering amplitudes in gauge theory and gravity, and their implications for ultraviolet divergences in supergravity.Comment: LaTex with package axodraw.sty. 10 pages. Presented by L.D. at Strings 99. Cosmetic changes onl

Remarks on the Classical Size of D-Branes

We discuss different criteria for `classical size' of extremal Dirichlet p-branes in type-II supergravity. Using strong-weak coupling duality, we find that the size of the strong-coupling region at the core of the (p<3)-branes, is always given by the asymptotic string scale, if measured in the weakly coupled dual string metric. We also point out how the eleven-dimensional Planck scale arises in the classical 0-brane solution, as well as the ten-dimensional Planck scale in the D-instanton solution.Comment: 8 pp, harvma

Momentum Analyticity and Finiteness of the 1-Loop Superstring Amplitude

The Type II Superstring amplitude to 1-loop order is given by an integral of $\vartheta$-functions over the moduli space of tori, which diverges for real momenta. We construct the analytic continuation which renders this amplitude well defined and finite, and we find the expected poles and cuts in the complex momentum plane.Comment: 10pp, /UCLA/93/TEP/