60 research outputs found
Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas
AbstractTreatment of neonatal rat islets of Langerhans with combined cytokines (interleukin-1β 10−10 M, tumour necrosis factor-α 10−10 M, interferon-γ 5 U/ml) led to extensive cell death, which was potentiated by Fas activation with the anti-Fas cytolytic antibody JO2. Pre-treatment with insulin (25 ng/ml) or insulin-like growth factor-1 (10−8 M) gave only partial protection against cell killing, but prevented the Fas-mediated component. In the absence of cytokine treatment, Fas-mediated killing was not observed
An international collaborative study of 'genetic drift' in Salmonella typhimurium strains used in Ames test
Second European workshop on bacterial in vitro mutagenicity test systems (Ames test meeting 1979). held at the Swiss Federal Research Station, CH-8820 Waedenswil, Switzerland, 2-3 April 1979
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