Providential Capitalism: Heavenly Intervention and the Atlantic’s Divine Economist

Providential capitalism names the marriage of providential Christian values and market-oriented capitalist ideology in the post-revolutionary Atlantic through the mid nineteenth century. This is a process by which individuals permitted themselves to be used by a so-called “divine economist” at work in the Atlantic market economy. Backed by a slave market, capital transactions were rendered as often violent ecstatic individual and cultural experiences. Those experiences also formed the bases for national, racial, and classed identification and negotiation among the constellated communities of the Atlantic. With this in mind, writers like Benjamin Franklin, Olaudah Equiano, and Ukawsaw Gronniosaw presented market success as proof of divine election. At the same time, writers like Richard Henry Dana Jr., Royall Tyler, and the anonymous author of Humanity in Algiers offered hegemonic expansion as an integral part of a divine capitalist plan. However, writers like Ottobah Cugoano, Venture Smith, John Jea, and, later, Edgar Allan Poe, in The Narrative of Arthur Gordon Pym of Nantucket, and Herman Melville, in Redburn: His First Voyage, recognized the dehumanizing potential of this power arrangement. They described the ways in which humans could be commodified or rendered invisible by the operations of a market that used individuals for its own ends and maintained the aegis of divine sovereignty. Urban Gothic novels like Charles Brockden Brown’s Arthur Mervyn or Memoirs of the Year 1793 and George Lippard’s The Quaker City, or The Monks of Monk Hall likewise commented upon the unsettling nationalist stakes of this power structure. This project reorients Atlantic critical and literary studies around this conflation of interests, philosophies, and theologies, which became culturally formative in the revolutionary period, blossomed throughout the post-revolutionary era, and reached a point of crisis by the mid-nineteenth century. Building upon current Atlantic scholarship, it uses a disparate array of authors and texts to demonstrate the diversity of responses to the emergence, proliferation, and watershed of providential capitalism for Atlantic cultures and individuals

Ground water and climate change

As the world’s largest distributed store of fresh water, ground water plays a central part in sustaining ecosystems and enabling human adaptation to climate variability and change. The strategic importance of ground water for global water and food security will probably intensify under climate change as more frequent and intense climate extremes (droughts and floods) increase variability in precipitation, soil moisture and surface water. Here we critically review recent research assessing the impacts of climate on ground water through natural and human-induced processes as well as through groundwater-driven feedbacks on the climate system. Furthermore, we examine the possible opportunities and challenges of using and sustaining groundwater resources in climate adaptation strategies, and highlight the lack of groundwater observations, which, at present, limits our understanding of the dynamic relationship between ground water and climate

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis