A christological interpretation of "The Golden String" of Bede Griffiths' Spiritual Journey

This thesis explores the Christological focus of the 'the Golden String,' the defining image of Bede Griffiths' spiritual journey while taking into account other images employed in relation to God, the self, and creation itself. Our exploratory narrative schema sets this metaphor in the wider history of Griffiths' development and places it into the context of his theological articulation of the contemplative vocation and related issues. A key interest is the movement of humankind to a new level of consciousness

Working with Pregnant & Postpartum Women with Opioid Use Dependence: Digital Storytelling as an Innovative Qualitative Data Collection Tool and Intervention

As part of the mini-symposium entitled Pregnant and Parenting Mothers with History of Opiate Addiction, this presentation describes a qualitative study that will use digital storytelling with pregnant women in a medication assisted treatment (MAT) program as an intervention to promote self-efficacy as well as a patient-centered data collection tool

Cross-Cutting Narratives of Opioid Use Disorder Among Pregnant Women and Mothers: Implications for Humanistic Care

Opioid-related fatalities in the U.S. have increased drastically. Pregnant women and mothers with opioid use disorders (OUD) are a rapidly growing and vulnerable population. Using a critical narrative approach, this dissertation examines how the syndemic of trauma, substance use, and mental health conditions influences opioid use and treatment trajectories among pregnant women and mothers across the lifecourse. The goal of this dissertation was to examine three discursive resources that shape the social construction of perinatal and maternal opioid use across all strata of social life: macro-level (news media), meso-level (scientific), and micro-level (individual) narratives. Informed by 18-months of ethnographic observation, in-depth interviews, and mixed methods analysis of scientific research and news media coverage of perinatal and maternal OUD, this research brings together the voices of women in recovery, clinicians, social workers, policymakers, and the public. Building from what Sanders (2014) refers to as the “gendered double standard” faced by women with substance use disorders, in this dissertation I characterize the intersecting identities of female, pregnant/mother, and substance user as a gendered triple standard. Throughout this work I argue that being held to this gendered triple standard intensifies the stigma faced by pregnant women and mothers with OUD as they navigate the medical, legal, and social service institutions. Key findings from this research include: (1) a predominating focus on “fetal victimhood” (Knight, 2015), which overlooks the needs of pregnant women and mothers with OUD that run concurrent to ensuring a healthy pregnancy and birth; (2) approaches to addressing the opioid “crisis” that elide key at-risk populations (e.g. People of Color, active substance users, and polysubstance users); (3) “folk” pharmacokinetic knowledge and practices utilized by pregnant women and mothers that function as both facilitators and barriers to treatment engagement; and (4) the traumas associated with institutional policies and procedures specific to the management of opioid use (e.g., practices associated with civil commitment to treatment, loss of custody, and intergenerational family separation via the criminal justice and/or foster care systems). Informed by key findings, this dissertation concludes with five specific recommendations for research and practice

A Data Mining Approach To identify Diabetes

Mounting amounts of data made traditional data analysis methods impractical. Data mining (DM) tools provide a useful for alternative framework that addresses this problem. This study follows a DM technique to identify diabetic patients. We develop a model that clusters diabetes patients of a large healthcare company into different subpopulation. Consequently, we show the value of applying a DM model to identify diabetic patients

Monitoring and evaluation of family interventions (Information on families supported to March 2010) RR044

Josie Dixon, Vera Schneider, Cheryl Lloyd, Alice Reeves, Clarissa White, Wojtek Tomaszewski, Rosie Green and Eleanor Irelan

Monitoring and evaluation of family interventions: information on families supported to March 2010 (Research report DFE-RR044)

"This report updates and builds on the previous research by presenting and analysing FIIS [Family intervention Information system] data provided by family intervention staff up to and including 31 March 2010. The report is primarily based on simple descriptive statistics which provide a summary of the quantitative evidence. In addition statistical modelling (logistic regression) was used to look at the factors associated with successful and unsuccessful outcomes." - Page 14

Pulmonary MicroRNA changes alter angiogenesis in chronic obstructive pulmonary disease and lung cancer

The pulmonary endothelium is dysfunctional in chronic obstructive pulmonary disease (COPD), a known risk factor for lung cancer. The pulmonary endothelium is altered in emphysema, which is disproportionately affected by cancers. Gene and microRNA expression differs between COPD and non-COPD lung. We hypothesised that the alteration in microRNA expression in the pulmonary endothelium contributes to its dysfunction. A total of 28 patients undergoing pulmonary resection were recruited and endothelial cells were isolated from healthy lung and tumour. MicroRNA expression was compared between COPD and non-COPD patients. Positive findings were confirmed by quantitative polymerase chain reaction (qPCR). Assays assessing angiogenesis and cellular migration were conducted in Human Umbilical Vein Endothelial Cells (n = 3–4) transfected with microRNA mimics and compared to cells transfected with negative control RNA. Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD. Over-expression of miR-181b-3p was associated with reduced endothelial sprouting (p < 0.05). miR-429 was overexpressed in lung cancer as well and exhibited a reduction in tubular formation. MicroRNA-driven changes in the pulmonary endothelium thus represent a novel mechanism driving emphysema. These processes warrant further study to determine if they may be therapeutic targets in COPD and lung cancer

Social origins, school type and higher education destinations

To what extent and why do social origins matter for access to higher education, including access to elite universities? What is the role of private and selective schooling? This paper uses the 1970 British Cohort Study (BCS70) to analyse the trajectories of a generation currently in early middle age. We find that the influence of social origins, especially parental education, remains when both a wide range of cognitive measures and school attainment are controlled. Attending a private school is powerfully predictive of gaining a university degree, and especially a degree from an elite institution, while grammar schooling does not appear to confer any advantage