Immunoglobulins intrathecal synthesis evaluation in bone marrow transplantation

The central nervous system involvement in chronic graft versus host disease (GVHD) has been suggested. Chronic GVHD resembles auto immune connective tissue disorders. In order to investigate the immunoglobulin intra blood brain barrier (BBB) synthesis during chronic GVHD, and contribute to understanding the pathophysiology of the disease, we studied 33 patients who underwent allogeneic bone marrow transplants (BMT) from HLA identical related donors. Immunoglobulin intra BBB synthesis was investigated quantitative and qualitatively. The samples were collected pre BMT, pos BMT and during chronic GVHD. There were no evidence of immunoglobulin intra BBB synthesis, and no oligoclonal bands were found. Only isolated cases suggested IgG and IgA intra BBB synthesis, and in one case IgM during GVHD.UNIV FED PARANA,HOSP CLIN,SERV TMO,BR-80060900 CURITIBA,PARANA,BRAZILUNIV FED PARANA,HOSP CLIN,DISCIPLINA NEUROL,BR-80060900 CURITIBA,PARANA,BRAZILUNIFESP,ESCOLA PAULISTA MED,DISCIPLINA IMUNOL,SAO PAULO,BRAZILUNIV SAO PAULO,FAC MED,CTR INVEST NEUROL,BR-05508 SAO PAULO,BRAZILUNIFESP,ESCOLA PAULISTA MED,DISCIPLINA IMUNOL,SAO PAULO,BRAZILWeb of Scienc