Materializing digital collecting: an extended view of digital materiality

If digital objects are abundant and ubiquitous, why should consumers pay for, much less collect them? The qualities of digital code present numerous challenges for collecting, yet digital collecting can and does occur. We explore the role of companies in constructing digital consumption objects that encourage and support collecting behaviours, identifying material configuration techniques that materialise these objects as elusive and authentic. Such techniques, we argue, may facilitate those pleasures of collecting otherwise absent in the digital realm. We extend theories of collecting by highlighting the role of objects and the companies that construct them in materialising digital collecting. More broadly, we extend theories of digital materiality by highlighting processes of digital material configuration that occur in the pre-objectification phase of materialisation, acknowledging the role of marketing and design in shaping the qualities exhibited by digital consumption objects and consequently related consumption behaviours and experiences

Microflares and the Statistics of X-ray Flares

This review surveys the statistics of solar X-ray flares, emphasising the new views that RHESSI has given us of the weaker events (the microflares). The new data reveal that these microflares strongly resemble more energetic events in most respects; they occur solely within active regions and exhibit high-temperature/nonthermal emissions in approximately the same proportion as major events. We discuss the distributions of flare parameters (e.g., peak flux) and how these parameters correlate, for instance via the Neupert effect. We also highlight the systematic biases involved in intercomparing data representing many decades of event magnitude. The intermittency of the flare/microflare occurrence, both in space and in time, argues that these discrete events do not explain general coronal heating, either in active regions or in the quiet Sun.Comment: To be published in Space Science Reviews (2011

Overcoming TRAIL-resistance by sensitizing prostate cancer 3D spheroids with taxanes

Data used to generate figures of the paper “Overcoming TRAIL-resistance by sensitizing prostate cancer 3D spheroids with taxanes” Grayson KA, Jyotsana N, Ortiz-Otero N, King MR. PLOS One. 2021. In this study, we demonstrate that the taxanes, docetaxel and cabazitaxel, sensitizes prostate cancer cells in 2D and 3D cell culture environments to TRAIL

Improving antimicrobial stewardship by antibiotic allergy delabeling: Evaluation of knowledge, attitude, and practices throughout the emerging infections network

Antibiotic allergy testing (AAT) practices of Emerging Infections Network infectious disease physicians were surveyed. Although AAT was perceived to be necessary for removal of inappropriate or unnecessary allergy labels, there was limited access to any form of testing. In this study, we discuss current antibiotic allergy knowledge gaps and the development of AAT practices within antimicrobial stewardship programs, which will potentially improve antimicrobial prescribing

Beta-Lactam and sulfonamide allergy testing should be a standard of care in immunocompromised host

This work was supported by the Austin Medical Research Foundation. J.A.T. is supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship (GNT 1139902) and a postgraduate scholarship from the National Centre for Infections in Cancer, NHMRC, Centre for Research Excellence (App 1116876). E.J.P. receives grant support from the National Institutes of Health (award nos. 1P50GM115305-01) and the NHMRC

How antibiotic allergy labels may be harming our most vulnerable patients

Antibiotic allergy testing programs will ensure that vulnerable patients receive appropriate antibiotic therapy..

Antibiotic allergy testing improves antibiotic appropriateness in patients with cancer

Research lette

The 3 Cs of antibiotic allergy—classification, cross-reactivity, and collaboration

Antibiotic allergy labeling is highly prevalent and negatively impacts patient outcomes and antibiotic appropriateness. Reducing the prevalence and burden of antibiotic allergies requires the engagement of key stakeholders such as allergists, immunologists, pharmacists, and infectious diseases physicians. To help address this burden of antibiotic allergy overlabeling, we review 3 key antibiotic allergy domains: (1) antibiotic allergy classification, (2) antibiotic cross-reactivity, and (3) multidisciplinary collaboration. We review the available evidence and research gaps of currently used adverse drug reaction classification systems, antibiotic allergy cross-reactivity, and current and future models of antibiotic allergy care