The effect of high intensity interval exercise on postprandial triacylglycerol and leukocyte activation - monitored for 48h post exercise

Peer reviewedPublisher PD

Experience of compassion-based practice in mindfulness for health for individuals with persistent pain

Purpose of the Study Research indicates that acquiring compassion is an integral part to positive outcomes to Mindfulness-based interventions (MBI), yet there is both theoretic and empirical literature suggesting that people with persistent pain are more likely to experience challenges and distress when engaging compassion-based practices. Mindfulness for Health is a standardised MBI for people with persistent pain and health conditions. This study sought to explore the positive, neutral and difficult experiences of compassion-based practice and meditation for participants in Mindfulness for Health to further understand implications and risks for participants of MBI’s. Method and Design A qualitative design using Interpretative Phenomenological Analysis was applied to explore how participants understood of the experience of compassion-based practice and the meaning they gave to it. Eight participants who had completed the Mindfulness for Health from four separate groups were interviewed about their experience. Results Five master themes were identified ‘turning away from self-with-pain’, ‘self-with-pain experienced as shameful’, ‘facilitating change’, ‘turning towards self-with-pain’, and ‘accepting self’. Participants identified both perceived positive changes and difficult emotional experiences during the meditation practice, which they related to the context of compassion in their past and present life. Conclusions Developing compassion is an important part of Mindfulness for Health, which is salient for participants as both a challenging and potentially valuable experience. Acquisition of mindfulness skills, supporting group dynamics and modelling compassion are understood as helpful in overcoming personal barriers and challenging experiences. Further research is needed to understand processes involved and explore the experience of non-completers

MTCT regimrnt choice, drug resistance and the treatment of HIV-1-Infected children

No Abstract

Examining Mattering, Spiritual Mattering, and First-Year Retention at a Private, Religiously-Affiliated Institution of Higher Education

The primary purpose of this project was to explore how Schlossberg’s (1989) theory of college student’s mattering relates to college student retention in the context of a Christian institution of higher education. In addition, the authors created and tested a “spiritual mattering” measure based on Schlossberg’s theory. Mattering is a self-perception that refers to how important we believe we are to others. Schlossberg (1989) inserted this concept into the realm of higher education when she examined mattering and adult students returning to college. The purpose of the study was accomplished through the following three research objectives: a) Determining whether “institutional” mattering predicts fall-to-fall semester persistence of first-year students at a religiously-affiliated campus; b) Constructing a spiritual mattering measure and assessing its psychometric properties; and c) Determining whether spiritual mattering predicts fall-to-fall semester persistence of first-year students at a Christian institution of higher education. The results of the study supported the hypothesis that higher scores for both spiritual mattering and university mattering were significantly related to higher retention rates at an institution of higher education

Cataract surgery and quality of life implications

Cataract surgery in the developed world has undergone a revolution over the last 20 years. An operation which used to require a stay in hospital and long visual rehabilitation is now a quick day-case procedure with immediate benefits. As with any surgery there is an associated morbidity, but there is now the potential to provide cataract surgery at an earlier stage of cataract maturation and save patients from a period of severe visual impairment. This article reviews the new techniques available to measure the impact that cataracts have not only on a patient’s visual acuity but also their general physical health, function, cognition, and emotional well-being. New research is described that takes into account these more holistic tests and how they can be used to judge the best time to refer and operate on a patient with cataracts

Insensitivity of Paediatric HIV-1 Subtype C Viruses to Broadly Neutralising Monoclonal Antibodies Raised against Subtype B

BACKGROUND: A Phase I clinical trial has been proposed that uses neutralising monoclonal antibodies (MAbs) as passive immunoprophylaxis to prevent mother-to-child transmission of HIV-1 in South Africa. To assess the suitability of such an approach, we determined the sensitivity of paediatric HIV-1 subtype C viruses to the broadly neutralising MAbs IgG1b12, 2G12, 2F5, and 4E10. METHODS AND FINDINGS: The gp160 envelope genes from seven children with HIV-1 subtype C infection were cloned and used to construct Env-pseudotyped viruses that were tested in a single-cycle neutralisation assay. The epitopes defining three of these MAbs were determined from sequence analysis of the envelope genes. None of the seven HIV-1 subtype C pseudovirions was sensitive to 2G12 or 2F5, which correlated with the absence of crucial N-linked glycans that define the 2G12 epitope and substitutions of residues integral to the 2F5 epitope. Four viruses were sensitive to IgG1b12, and all seven viruses were sensitive to 4E10. CONCLUSIONS: Only 4E10 showed significant activity against HIV-1 subtype C isolates, while 2G12 and 2F5 MAbs were ineffective and IgG1b12 was partly effective. It is therefore recommended that 2G12 and 2F5 MAbs not be used for passive immunization experiments in southern Africa and other regions where HIV-1 subtype C viruses predominate

Prevention of mother-to-child Transmission: A report-back from the XV International AIDS Conference, Bangkok, 11 - 16 July 2004

The XV International AIDS Conference was held in Bangkok from 11 to 16 July 2004. The theme of the conference was ‘Access for all\'. It was an enormous gathering; 10 000 abstracts were accepted for presentation, of which approximately 400 were oral. There were 19 500 attendees from all over the globe with a high representation from Asian countries. South Africa was well represented by a large contingent including politicians, researchers, activists and government officials. The abstracts and presentations which may have an impact on policy and research directions have been reviewed and are summarised. Southern African Journal of HIV Medicine Vol. 5 (3) 2004: 17-2

Mendelian randomization in family data

The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques. We present an approach to instrumental variable estimation that is useful in family data and is robust to the use of weak instruments. We illustrate our method to measure the causal influence of low-density lipoprotein on high-density lipoprotein, body mass index, triglycerides, and systolic blood pressure. We use the Framingham Heart Study data as distributed to participants in the Genetics Analysis Workshop 16