Hybrid SPECT/CT for the assessment of a painful hip after uncemented total hip arthroplasty

Background The diagnosis of hip pain after total hip replacement (THR) represents a highly challenging question that is of increasing concern to orthopedic surgeons. This retrospective study assesses bone scintigraphy with Hybrid SPECT/CT for the diagnosis of painful THR in a selected cohort of patients. Methods Bone SPECT/CT datasets of 23 patients (mean age 68.9 years) with a painful hip after THR were evaluated. Selection of the patients required an inconclusive radiograph, normal serum levels of inflammatory parameters (CRP and ESR) or a negative aspiration of the hip joint prior to the examination. The standard of reference was established by an interdisciplinary adjudication-panel using all imaging data and clinical follow-up data (>12 month). Pathological and physiological uptake patterns were defined and applied. Results The cause of pain in this study group could be determined in 18 out of 23 cases. Reasons were aseptic loosening (n = 5), spine-related (n = 5), heterotopic ossification (n = 5), neuronal (n = 1), septic loosening (n = 1) and periprosthetic stress fracture (n = 1). In (n = 5) cases the cause of hip pain could not be identified. SPECT/CT imaging correctly identified the cause of pain in (n = 13) cases, in which the integrated CT-information led to the correct diagnosis in (n = 4) cases, mainly through superior anatomic correlation. Loosening was correctly assessed in all cases with a definite diagnosis. Conclusions SPECT/CT of THA reliably detects or rules out loosening and provides valuable information about heterotopic ossifications. Furthermore differential diagnoses may be detected with a whole-body scan and mechanical or osseous failure is covered by CT- imaging. SPECT/CT holds great potential for imaging-based assessment of painful prostheses

To-SYN-fuel project implements a new integrated process to produce synthetic fuels

The H2020 To-Syn-Fuel project aims to demonstrate a sustainable process able to transform waste biomass such as dried sewage sludge into renewable liquid fuels and hydrogen. The Thermo-Catalytic Reforming TCR® is implemented in a new process integrated with hydrodeoxygenation (HDO) and pressure swing adsorption (PSA) technologies to convert a wide range of residual biomass into three main products: H2-rich synthesis gas, biochar and a liquid bio-oil that can be upgraded to green fuels capable of being used directly in automotive internal combustion engines without modification, as they fulfil EN fuel standards. In this project, the operational capacity of TCR® is designed for up to 500 kg per hour of sewage sludge at a water content of 5-15 %. The main purpose of this unit is the long-term operation of a pre-commercial demonstrator. This is the final step of development before the technology reaches full commercial scale. This integrated unit is ready to operate from summer 2021 for up to 5,000 hours of operation and for the production of more than 200,000 liters of biocrude oil. By the end of the project the TCR®/PSA/HDO technology will have been validated at TRL-7 (system prototype demonstration in operational environment) and the business plan and environmental/social sustainability analysis for the technology will be complete