100 research outputs found
Short-term mental distress in research participants after receiving cardiovascular risk information.
Background
Understanding of how cardiovascular risk information influence individuals is critical for the
practice of risk assessment and the management of patients with cardiovascular disease.
Objectives
The objective of this study was to investigate change in mental distress among research
participants after undergoing a cardiovascular risk assessment and receiving individual test
results.
Methods
In 2017, a question
Exploring research participants' perceptions of cardiovascular risk information-Room for improvement and empowerment
Objective
The objective of this study was to explore research participantsâ (adults, age 50â65) perceptions of receiving cardiovascular risk information.
Methods
Five focus group interviews (Nâ=â31) were performed with research participants aged 50â65 who participated in the Swedish CArdioPulmonary BioImage Study (SCAPIS). The interviews were analyzed using qualitative content analysis.
Results
The categories;
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Mutations in epigenetic regulators including SETD2 are gained during relapse in pediatric acute lymphoblastic leukemia
Relapsed pediatric acute lymphoblastic leukemia (ALL) has high rates of treatment failure. Epigenetic regulators have been proposed as modulators of chemoresistance, here we sequence genes encoding epigenetic regulators in matched diagnosis-remission-relapse ALL samples. We find significant enrichment of mutations in epigenetic regulators at relapse with recurrent somatic mutations in SETD2, CREBBP, MSH6, KDM6A and MLL2, mutations in signaling factors are not enriched. Somatic alterations in SETD2, including frameshift and nonsense mutations, are present at 12% in a large de novo ALL patient cohort. We conclude that the enrichment of mutations in epigenetic regulators at relapse is consistent with a role in mediating therapy resistance
A novel asynchronous access method with binary interfaces
© 2008 Silva et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
The influence of temperature on the development of Baltic Sea sprat (Sprattus sprattus) eggs and yolk sac larvae
In spring 2004 and 2005 we performed two sets of experiments with Baltic sprat (Sprattus sprattus balticus Schneider) eggs and larvae from the Bornholm Basin simulating ten different temperature scenarios. The goal of the present study was to analyse and parameterise temperature effects on the duration of developmental stages, on the timing of important ontogenetic transitions, growth during the yolk sac phase as well as on the survival success of eggs and early larval stages. Egg development and hatching showed exponential temperature dependence. No hatching was observed above 14.7°C and hatching success was significantly reduced below 3.4°C. Time to eye pigmentation, as a proxy for mouth gape opening, decreased with increasing temperatures from 17 days post hatch at 3.4°C to 7 days at 13°C whereas the larval yolk sac phase was shortened from 20 to 10 days at 3.8 and 10°C respectively. Maximum survival duration of non-fed larvae was 25 days at 6.8°C. Comparing the experimental results of Baltic sprat with existing information on sprat from the English Channel and North Sea differences were detected in egg development rate, thermal adaptation and in yolk sac depletion rate (YSDR). Sprat eggs from the English Channel showed significantly faster development and the potential to develop at temperatures higher than 14.7°C. North Sea sprat larvae were found to have a lower YSDR compared to larvae from the Baltic Sea. In light of the predictions for global warming, Baltic sprat stocks could experience improved conditions for egg development and surviva
A Domain-Agnostic Approach for Characterization of Lifelong Learning Systems
Despite the advancement of machine learning techniques in recent years,
state-of-the-art systems lack robustness to "real world" events, where the
input distributions and tasks encountered by the deployed systems will not be
limited to the original training context, and systems will instead need to
adapt to novel distributions and tasks while deployed. This critical gap may be
addressed through the development of "Lifelong Learning" systems that are
capable of 1) Continuous Learning, 2) Transfer and Adaptation, and 3)
Scalability. Unfortunately, efforts to improve these capabilities are typically
treated as distinct areas of research that are assessed independently, without
regard to the impact of each separate capability on other aspects of the
system. We instead propose a holistic approach, using a suite of metrics and an
evaluation framework to assess Lifelong Learning in a principled way that is
agnostic to specific domains or system techniques. Through five case studies,
we show that this suite of metrics can inform the development of varied and
complex Lifelong Learning systems. We highlight how the proposed suite of
metrics quantifies performance trade-offs present during Lifelong Learning
system development - both the widely discussed Stability-Plasticity dilemma and
the newly proposed relationship between Sample Efficient and Robust Learning.
Further, we make recommendations for the formulation and use of metrics to
guide the continuing development of Lifelong Learning systems and assess their
progress in the future.Comment: To appear in Neural Network
Intelligent Interfaces to Empower People with Disabilities
Severe motion impairments can result from non-progressive disorders, such as cerebral palsy, or degenerative neurological diseases, such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), or muscular dystrophy (MD). They can be due to traumatic brain injuries, for example, due to a traffic accident, or to brainste
Weakly Supervised Localization and Learning with Generic Knowledge
ISSN:0920-5691ISSN:1573-140
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