An Algebra of Pieces of Space -- Hermann Grassmann to Gian Carlo Rota

We sketch the outlines of Gian Carlo Rota's interaction with the ideas that Hermann Grassmann developed in his Ausdehnungslehre of 1844 and 1862, as adapted and explained by Giuseppe Peano in 1888. This leads us past what Rota variously called 'Grassmann-Cayley algebra', or 'Peano spaces', to the Whitney algebra of a matroid, and finally to a resolution of the question "What, really, was Grassmann's regressive product?". This final question is the subject of ongoing joint work with Andrea Brini, Francesco Regonati, and William Schmitt. The present paper was presented at the conference "The Digital Footprint of Gian-Carlo Rota: Marbles, Boxes and Philosophy" in Milano on 17 Feb 2009. It will appear in proceedings of that conference, to be published by Springer Verlag.Comment: 28 page

Development and Application of a Statistically-Based Quality Control for Crowdsourced Air Temperature Data

In urban areas, dense atmospheric observational networks with high-quality data are still a challenge due to high costs for installation and maintenance over time. Citizen weather stations (CWS) could be one answer to that issue. Since more and more owners of CWS share their measurement data publicly, crowdsourcing, i.e., the automated collection of large amounts of data from an undefined crowd of citizens, opens new pathways for atmospheric research. However, the most critical issue is found to be the quality of data from such networks. In this study, a statistically-based quality control (QC) is developed to identify suspicious air temperature (T) measurements from crowdsourced data sets. The newly developed QC exploits the combined knowledge of the dense network of CWS to statistically identify implausible measurements, independent of external reference data. The evaluation of the QC is performed using data from Netatmo CWS in Toulouse, France, and Berlin, Germany, over a 1-year period (July 2016 to June 2017), comparing the quality-controlled data with data from two networks of reference stations. The new QC efficiently identifies erroneous data due to solar exposition and siting issues, which are common error sources of CWS. Estimation of T is improved when averaging data from a group of stations within a restricted area rather than relying on data of individual CWS. However, a positive deviation in CWS data compared to reference data is identified, particularly for daily minimum T. To illustrate the transferability of the newly developed QC and the applicability of CWS data, a mapping of T is performed over the city of Paris, France, where spatial density of CWS is especially high.DFG, 322579844, Hitzewellen in Berlin, Deutschland - StadtklimamodifkationenBMBF, 01LP1602A, Verbundprojekt Stadtklima: Evaluierung von Stadtklimamodellen (Modul B), 3DO Teilprojekt 1: Dreidimensionales Monitoring atmosphärischer Prozesse in Berli

Finding equilibrium probabilities of QBD processes by spectral methods when eigenvalues vanish

AbstractIn this paper, we discuss the use of spectral or eigenvalue methods for finding the equilibrium probabilities of quasi-birth–death processes for the case where some eigenvalues are zero. Since this leads to multiple eigenvalues at zero, a difficult problem to analyze, we suggest to eliminate such eigenvalues. To accomplish this, the dimension of the largest Jordan block must be established, and some initial equations must be eliminated. The method is demonstrated by two examples, one dealing with a tandem queue, the other one with a shorter queue problem

Pierwszy raport z badań piwnic pałacu Branickich

Artykuł stanowi podsumowanie badań historycznych, architektonicznych i archeologicznych, przeprowadzonych przez Atelier Zetta w piwnicach pałacu Branickich w Białymstoku w 2011 r. Zespół badaczy tworzyli: mgr inż. arch. Zenon Zabagło, dr inż. arch. Marek Barański, mgr inż. arch. Paweł Kinsner, mgr inż. arch. Leszek Dobrowolski, mgr archeologii Stanisław Petrykowski, mgr historii Wiesław Wróbel oraz mgr inż. arch. Karolina Porowska

The linear mirror for solar energy exploitation

We describe a simple two-dimensional array of plane mirrors operated by only two motors, which collects efficiently Sun light in order to produce electrical power at about the cost of oil. The system preserves the merits of previous state-of-the-art solar power plants but is simpler and by far less expensive. A first prototype has been operated at the Physics Department of the University of Udine providing a power of 0.56 kW per m2 of mirror surface in mid November

MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes

<p>Abstract</p> <p>Background</p> <p>Human T-lymphotropic virus type 1 (HTLV-1) is the etiologic agent of a severe and fatal lymphoproliferative disease of mainly CD4⁺T cell origin, adult T cell leukemia, which develops after prolonged viral persistence. Transformation of infected cells involves HTLV-1's oncoprotein Tax, which perturbs cell cycle regulation and modulates cellular gene expression. The latter function is also a hallmark of microRNAs, a rather new layer in the regulation of gene expression. Affecting e.g. proliferation, microRNAs constitute a potential target for viral interference on the way to persistence and transformation. Hence, we explored the interconnections between HTLV-1 and cellular microRNAs.</p> <p>Results</p> <p>We report that several microRNAs – miRs 21, 24, 146a, 155 and 223 – are deregulated in HTLV-1-transformed cells. They are all upregulated except for miR-223, which is downregulated. Each of those microRNAs has ties to cancer. Their expression pattern forms a uniform phenotype among HTLV-transformed cells when compared to HTLV-negative control cells. In particular, miR-146a expression was found to be directly stimulated by Tax via NF-<it>κ</it>B-mediated transactivation of its promoter; a single NF-<it>κ</it>B site proximal to the transcription start point was necessary and sufficient for this to happen. An <it>in silico </it>analysis of potential target genes revealed candidates that might be coregulated by two or more of the aforementioned overexpressed microRNAs.</p> <p>Conclusion</p> <p>These data demonstrate that cellular microRNAs are deregulated in HTLV-1-transformed T cells. In the case of miR-146a, this could be directly attributed to HTLV's oncoprotein Tax. Interference with cellular microRNAs may be crucial to maintaining persistence or may facilitate transformation of host cells.</p

Children’s level of word knowledge predicts their exclusion of familiar objects as referents of novel words

When children are learning a novel object label, they tend to exclude as possible referents familiar objects for which they already have a name. In the current study, we wanted to know if children would behave in this same way regardless of how well they knew the name of potential referent objects, specifically, whether they could only comprehend it or they could both comprehend and produce it. Sixty-six monolingual German-speaking 2-, 3-, and 4-year-old children participated in two experimental sessions. In one session the familiar objects were chosen such that their labels were in the children’s productive vocabularies, and in the other session the familiar objects were chosen such that their labels were only in the children’s receptive vocabularies. Results indicated that children at all three ages were more likely to exclude a familiar object as the potential referent of the novel word if they could comprehend and produce its name rather than comprehend its name only. Indeed, level of word knowledge as operationalized in this way was a better predictor than was age. These results are discussed in the context of current theories of word learning by exclusion

The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix

BACKGROUND: The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) is leukemogenic in transgenic mice and induces permanent T-cell growth in vitro. It is found in active CDK holoenzyme complexes from adult T-cell leukemia-derived cultures and stimulates the G1- to-S phase transition by activating the cyclin-dependent kinase (CDK) CDK4. The Tax protein directly and specifically interacts with CDK4 and cyclin D2 and binding is required for enhanced CDK4 kinase activity. The protein-protein contact between Tax and the components of the cyclin D/CDK complexes increases the association of CDK4 and its positive regulatory subunit cyclin D and renders the complex resistant to p21(CIP )inhibition. Tax mutants affecting the N-terminus cannot bind cyclin D and CDK4. RESULTS: To analyze, whether the N-terminus of Tax is capable of CDK4-binding, in vitro binding -, pull down -, and mammalian two-hybrid analyses were performed. These experiments revealed that a segment of 40 amino acids is sufficient to interact with CDK4 and cyclin D2. To define a Tax-binding domain and analyze how Tax influences the kinase activity, a series of CDK4 deletion mutants was tested. Different assays revealed two regions which upon deletion consistently result in reduced binding activity. These were isolated and subjected to mammalian two-hybrid analysis to test their potential to interact with the Tax N-terminus. These experiments concurrently revealed binding at the N- and C-terminus of CDK4. The N-terminal segment contains the PSTAIRE helix, which is known to control the access of substrate to the active cleft of CDK4 and thus the kinase activity. CONCLUSION: Since the N- and C-terminus of CDK4 are neighboring in the predicted three-dimensional protein structure, it is conceivable that they comprise a single binding domain, which interacts with the Tax N-terminus