1,080 research outputs found

    Examination of High School Students\u27 Understanding of Geometry

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    Not every student learns geometry instruction the same. Inside today’s classroom, one will find a diverse collection of students with different learning styles, background knowledge, and cognitive abilities. Students with high cognitive skills may sit next to those who struggle to maintain the material of a single subject. It is the job of an educator to accept the students as they are and guide them through a successful academic journey. This process is called Differentiated Instruction. Gregory and Chapman, authors of Differentiated Instructional Strategies: One Size Doesn’t Fit All, state that the term differentiation is a philosophy that allows instructors the ability to plan their classes in a strategic manner in order to meet the needs of each diverse learner in the classroom. Tomlinson states that teachers can differentiate instruction in four main areas: content, process, products, and learning environment. In order to test the effectiveness of differentiated instruction, the researcher gathered and analyzed data from a 2014 spring geometry class. This study attempted to draw comparisons between differentiated lessons versus traditional lecture based lessons

    The cardiac and haemostatic effects of dietary hempseed

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    Despite its use in our diet for hundreds of years, hempseed has surprisingly little research published on its physiological effects. This may have been in the past because the psychotropic properties wrongly attributed to hemp would complicate any conclusions obtained through its study. Hemp has a botanical relationship to drug/medicinal varieties of Cannabis. However, hempseed no longer contains psychotropic action and instead may provide significant health benefits. Hempseed has an excellent content of omega-3 and omega-6 fatty acids. These compounds have beneficial effects on our cardiovascular health. Recent studies, mostly in animals, have examined the effects of these fatty acids and dietary hempseed itself on platelet aggregation, ischemic heart disease and other aspects of our cardiovascular health. The purpose of this article is to review the latest developments in this rapidly emerging research field with a focus on the cardiac and vascular effects of dietary hempseed

    Vegetative and Climatic Controls on Holocene Wildfire and Erosion Recorded in Alluvial Fans of the Middle Fork Salmon River, Idaho

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    The Middle Fork Salmon River watershed spans high-elevation mixed-conifer forests to lower-elevation shrub-steppe. In recent decades, runoff from severely burned hillslopes has generated large debris flows in steep tributary drainages. These flows incised alluvial fans along the mainstem river, where charcoal-rich debris-flow and sheetflood deposits preserve a record of latest Pleistocene to Holocene fires and geomorphic response. Through deposit sedimentology and 14C dating of charcoal, we evaluate the processes and timing of fire-related sedimentation and the role of climate and vegetation change. Fire-related deposits compose ~66% of the total measured fan deposit thickness in more densely forested upper basins versus ~33% in shrub-steppe-dominated lower basins. Fires during the middle Holocene (~8000 - 5000 cal yr BP) mostly resulted in sheetflood deposition, similar to modern events in lower basins. Decreased vegetation density during this generally warmer and drier period likely resulted in lower-severity fires and more frequent but smaller fire-related sedimentation events. In contrast, thick fire-related debris-flow deposits of latest Pleistocene-early Holocene (~13,500-8000 cal yr BP) and late Holocene (\u3c 4000 cal yr BP) age are inferred to represent higher-severity fires, though data in the former period are limited. Widespread fires occurred in both upper and lower basins within the Medieval Climatic Anomaly (1050-650 cal yr BP) and the early Little Ice Age ca. 550 cal yr BP. We conclude that a generally cooler late Holocene climate and a shift to denser lodgepole pine forests in upper basins by ~2500 cal yr BP provided fuel for severe fires during episodic droughts

    Can Deliberative Democracy Work in Hierarchical Organizations?

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    Some measure of equality is necessary for deliberative democracy to work well, yet empirical scholarship consistently points to the deleterious effect that hierarchy and inequalities of epistemological authority have on deliberation. This article tests whether real-world deliberative forums can overcome these challenges. Contrary to skeptics, it concludes that the act of deliberation itself and the presence of trained moderators ameliorate inequalities of epistemological authority, thus rendering deliberative democracy possible, even within hierarchical organizations

    Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes

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    Background: The retina is a complex tissue comprised of multiple cell types that is affected by a diverse set of diseases that are important causes of vision loss. Characterizing the transcripts, both annotated and novel, that are expressed in a given tissue has become vital for understanding the mechanisms underlying the pathology of disease. Results: We sequenced RNA prepared from three normal human retinas and characterized the retinal transcriptome at an unprecedented level due to the increased depth of sampling provided by the RNA-seq approach. We used a non-redundant reference transcriptome from all of the empirically-determined human reference tracks to identify annotated and novel sequences expressed in the retina. We detected 79,915 novel alternative splicing events, including 29,887 novel exons, 21,757 3′ and 5′ alternate splice sites, and 28,271 exon skipping events. We also identified 116 potential novel genes. These data represent a significant addition to the annotated human transcriptome. For example, the novel exons detected increase the number of identified exons by 3%. Using a high-throughput RNA capture approach to validate 14,696 of these novel transcriptome features we found that 99% of the putative novel events can be reproducibly detected. Further, 15-36% of the novel splicing events maintain an open reading frame, suggesting they produce novel protein products. Conclusions: To our knowledge, this is the first application of RNA capture to perform large-scale validation of novel transcriptome features. In total, these analyses provide extensive detail about a previously uncharacterized level of transcript diversity in the human retina

    Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes

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    Background: The retina is a complex tissue comprised of multiple cell types that is affected by a diverse set of diseases that are important causes of vision loss. Characterizing the transcripts, both annotated and novel, that are expressed in a given tissue has become vital for understanding the mechanisms underlying the pathology of disease. Results: We sequenced RNA prepared from three normal human retinas and characterized the retinal transcriptome at an unprecedented level due to the increased depth of sampling provided by the RNA-seq approach. We used a non-redundant reference transcriptome from all of the empirically-determined human reference tracks to identify annotated and novel sequences expressed in the retina. We detected 79,915 novel alternative splicing events, including 29,887 novel exons, 21,757 3′ and 5′ alternate splice sites, and 28,271 exon skipping events. We also identified 116 potential novel genes. These data represent a significant addition to the annotated human transcriptome. For example, the novel exons detected increase the number of identified exons by 3%. Using a high-throughput RNA capture approach to validate 14,696 of these novel transcriptome features we found that 99% of the putative novel events can be reproducibly detected. Further, 15-36% of the novel splicing events maintain an open reading frame, suggesting they produce novel protein products. Conclusions: To our knowledge, this is the first application of RNA capture to perform large-scale validation of novel transcriptome features. In total, these analyses provide extensive detail about a previously uncharacterized level of transcript diversity in the human retina

    Come-See-Me Festival Interview

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    In this April 21, 1978 interview, the origins and history of the Come-See-Me Festival are discussed. Included is an overview of the events for the 1978 event. This interview was conducted for inclusion into the Louise Pettus Archives and Special Collections Oral History Programhttps://digitalcommons.winthrop.edu/oralhistoryprogram/1265/thumbnail.jp

    Fire and Ice in Central Idaho: Modern and Holocene Fires, Debris Flows, and Climate in the Payette River Basin, and Quaternary and Glacial Geology in the Sawtooth Mountains

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    This 2-day trip will highlight recent fire and storm-related debris flows in the Payette River region, Holocene records of fires and fire-related sedimentation events preserved in alluvial fan stratigraphic sequences, and geomorphology and geology of alpine glaciations in the spectacular Sawtooth Mountains and Stanley Basin of central Idaho. Storm events and associated scour following recent fires in the South Fork Payette basin have exposed Holocene fire-related debris-flow deposits, flood sediments, and other alluvial fan-building deposits that yield insights into Holocene environmental change. Moraine characteristics and sediment cores from the southeastern Sawtooth Mountains and Stanley Basin provide evidence of late Pleistocene alpine glaciation. A combination of these glacial records with reconstructions of regional equilibrium line elevations produces late-glacial paleoclimatic inferences for the area. Day one of the trip will examine recent and Holocene fire-related deposits along the South Fork Payette River; day two will focus on alpine glaciation in the Sawtooth Mountains (fig. 1). A description of the scope, methods, results and interpretation of the South Fork Payette fire study is given below. Background information on late Pleistocene alpine glaciation in the eastern Sawtooth Mountains is presented with the material for day 2 of the trip. The road log for day 1 of the trip begins at Banks, Idaho, and ends in Stanley, Idaho. Stop locations are shown on figure 2. At Stop 1, we will provide an introduction to interpretation of alluvial fan stratigraphic sections, and discuss the Boise Ridge fault. At Stops 2–4 (Hopkins Creek, Deadwood River, and Jughead creek), we will examine recent debrisflow deposits and Holocene alluvial fan stratigraphic sections. At Stop 5 (Helende Campground), we will look at a series of well-preserved Holocene and Pleistocene terraces and at Stop 6 (Canyon Creek), we will briefly inspect fire-related deposits in higher-elevation alluvial fan stratigraphic sections. The road log for day 2 begins at Stanley, Idaho, and ends in Sun Valley, Idaho. Stop locations are shown on figure 2. Stop 1, at Redfish Lake, will focus on regional equilibrium line altitude reconstructions and on the general pattern of late Pleistocene glaciation on the eastern flank of the Sawtooth Mountains. Stop 2 will be at Pettit Lake, where we will examine the moraine sequence and discuss relative weathering criteria and moraine groupings. At Stop 3, near Alturas Lake, we will discuss lake sediment coring, moraine chronology, and implications for latest Pleistocene paleoclimatic inferences. Stop 4 will be a brief stop at Galena Summit for an overview of the Sawtooth Mountains and a discussion of ice accumulation patterns. The trip will end at a set of moraines in the Trail Creek valley, near Sun Valley, where we will examine moraine morphology and weathering rind data that constrain the moraine ages

    Is proflavine exposure associated with disease progression in women with cervical dysplasia? A brief report

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    Proflavine is an acridine dye used with high-resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short-term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow-up based on histopathologic results and per the local standards of care. Progression of disease was evaluated by comparing histopathology from the initial visit to the worst subsequent histopathology result from all follow-up visits. Mean duration of follow-up was 18.7 and 20.1 months for the proflavine-exposed and controls groups, respectively. There were no significant differences in disease progression from normal/CIN1 to CIN2/3 or from any initial diagnosis to invasive cancer between the proflavine exposed and control groups overall. Risks of cervical dysplasia progression observed in this study are in agreement with those of the natural history of cervical cancer. Our results suggest that cervical exposure to dilute proflavine does not increase the risk of cervical precancer and cancer.Research reported in this publication was supportedby the NCI of the NIH under Award Numbers UH2CA189910, UH3CA189910 and CA016672. The content is solely the responsibilityof the authors and does not necessarily represent the official views of the NIH.info:eu-repo/semantics/publishedVersio
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