7,571 research outputs found

    Review of Composition in the Age of Austerity, Nancy Welch and Tony Scott, Eds.

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    This review surveys the edited collection Composition in the Age of Austerity, which works at key intersections of interest to readers of Kairos: the discussion between critical and new materialisms, the debates about economics and digital humanities, and the 2016 election\u27s significance for our future as teachers, scholars, and champions of justice. The navigation bar at the top of each page in this webtext allows for reading in any particular order. The tabs of the navigation bar reflect my own reading across the sections and chapters included in the collection, offering my thinking with and against the premises of both the included works and the volume as a whole

    Oxidative stress via hydrogen peroxide and menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes

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    Conference abstract describing how oxidative stress via hydrogen peroxide and menadione does not induce the secretion of IGFBP-5 in primary rat hepatocytes. Presented at the 2010 annual congress of the british toxicology societ

    Outlook for detecting the gravitational wave displacement and spin memory effects with current and future gravitational wave detectors

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    Gravitational wave memory effects arise from non-oscillatory components of gravitational wave signals, and they are predictions of general relativity in the nonlinear regime that have close connections to the asymptotic properties of isolated gravitating systems. There are many types of memory effects that have been studied in the literature. In this paper we focus on the "displacement" and "spin" memories, which are expected to be the largest of these effects from sources such as the binary black hole mergers which have already been detected by LIGO and Virgo. The displacement memory is a change in the relative separation of two initially comoving observers due to a burst of gravitational waves, whereas the spin memory is a portion of the change in relative separation of observers with initial relative velocity. As both of these effects are small, LIGO, Virgo, and KAGRA can only detect memory effects from individual events that are much louder (and thus rarer) than those that have been detected so far. By combining data from multiple events, however, these effects could be detected in a population of binary mergers. In this paper, we present new forecasts for how long current and future detectors will need to operate in order to measure these effects from populations of binary black hole systems that are consistent with the populations inferred from the detections from LIGO and Virgo's first three observing runs. We find that a second-generation detector network of LIGO, Virgo, and KAGRA operating at the O4 ("design") sensitivity for 1.5 years and then operating at the O5 ("plus") sensitivity for an additional 1.5 years can detect the displacement memory. For Cosmic Explorer, we find that displacement memory could be detected for individual loud events, and that the spin memory could be detected in a population after 5 years of observation time.Comment: 18+7 pages, 8 figures; v2: fixed typos and errors and re-ran analysis (results unchanged), matches published versio

    Neurosteroid Influences on Sensitivity to Ethanol

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    This review will highlight a variety of mechanisms by which neurosteroids affect sensitivity to ethanol, including physiological states associated with activity of the hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–gonadal (HPG) axes, and the effects of chronic exposure to ethanol, in addition to behavioral implications. To date, γ-aminobutyric acid (GABAA) receptor mechanisms are a major focus of the modulation of ethanol effects by neuroactive steroids. While NMDA receptor mechanisms are gaining prominence in the literature, these complex data would be best discussed separately. Accordingly, GABAA receptor mechanisms are emphasized in this review with brief mention of some NMDA receptor mechanisms to point out contrasting neuroactive steroid pharmacology. Overall, the data suggest that neurosteroids are virtually ubiquitous modulators of inhibitory neurotransmission. Neurosteroids appear to affect sensitivity to ethanol in specific brain regions and, consequently, specific behavioral tests, possibly related to the efficacy and potency of ethanol to potentiate the release of GABA and increase neurosteroid concentrations. Although direct interaction of ethanol and neuroactive steroids at common receptor binding sites has been suggested in some studies, this proposition is still controversial. It is currently difficult to assign a specific mechanism by which neuroactive steroids could modulate the effects of ethanol in particular behavioral tasks
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