A typology of Indigenous engagement in Australian environmental management: implications for knowledge integration and social-ecological system sustainability

Indigenous peoples now engage with many decentralized approaches to environmental management that offer opportunities for integration of Indigenous Ecological Knowledge (IEK) and western science to promote cultural diversity in the management of social-ecological system sustainability. Nevertheless, processes of combining IEK with western science are diverse and affected by numerous factors, including the adaptive co-management context, the intrinsic characteristics of the natural resources, and the governance systems. We present a typology of Indigenous engagement in environmental management, derived through comparative analysis of 21 Australian case studies, and consider its implications for the integration of IEK with western science. Sociological and rational choice institutionalism underpin our analytical framework, which differentiates on three axes: (1) power sharing, incorporating decision making, rules definition, resource values and property rights; (2) participation, incorporating participatory processes, organizations engaged, and coordination approaches; (3) intercultural purpose, incorporating purposes of environmental management, Indigenous engagement, Indigenous development and capacity building. Our typology groups engagement into four types: Indigenous governed collaborations; Indigenous-driven co-governance; agency-driven co-governance; and agency governance. From our analysis of manifestations of knowledge integration across the types, we argue that Indigenous governance and Indigenous-driven co-governance provides better prospects for integration of IEK and western science for sustainability of social-ecological systems. Supporting Indigenous governance without, or with only a limited requirement for power sharing with other agencies sustains the distinct Indigenous cultural purposes underpinning IEK, and benefits knowledge integration. We conclude by advocating that the typology be applied to test its general effectiveness in guiding practitioners and researchers to develop robust governance for Indigenous knowledge integration in environmental management

Addressing the existential threat: climate change as a catalyst for reform in World Heritage

Climate change is putting cultural and natural assets of the world at risk, and Australia is no exception with many of our World Heritage properties at high risk from climate change. The challenges that climate change poses to World Heritage properties is complex, requiring multidisciplinary expertise including technical and legal experts in natural and cultural heritage, climate change, and diplomacy. The ideas generated by this roundtable aim to help the World Heritage community address the threat of climate change by addressing collective challenges, rather than on a property-by-property basis

Building capacity for climate adaptation planning in protected area management: Options and challenges for World Heritage

"Response and adaptation to the impacts of climate change is a vital and increasing requirement for protected area management. On the ground managers of cultural and natural values in protected places have requested practical guidance on how to undertake climate change impact analysis, vulnerability assessment, and adaptation plan- ning together with enhanced capacity for planning with partners, rightsholders and stakeholders. In this paper we explore how co-development and subsequent testing among World Heritage site managers, Indigenous ex- perts and researchers, produced guidance for assessing, responding to and planning for the impacts of climate change on the diverse values of World Heritage sites in Australia. We draw on the diversity of cultural and natural heritage values associated with the terrestrial, coastal and marine environments in Australian World Heritage sites, and the broad range of institutional contexts in these sites, to highlight considerations of relevance to other protected areas (including other World Heritage sites around the world, Ramsar wetlands and marine protected areas). Our paper highlights that, for climate adaptation planning to become a normal part of man- agement, there is a need for ongoing capacity building, including around the use of climate information to inform adaptation planning and implementation, as well as integrating Indigenous perspectives. Building capacity mayinvolve trial and error, negotiation, sharing, sourcing and interpreting new information, and changes in""expectations. It will require novel and more dynamic relationships between partners and stakeholders. Managers should include capacity building for climate adaptation planning and implementation as a specific climate"adaptation task in their planning.

Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML.

The reported influence of donor Killer-cell Immunoglobulin-like Receptor (KIR) genes on the outcomes of haematopoietic cell transplantation (HCT) are contradictory, in part due to diversity of disease, donor sources, era and conditioning regimens within and between different studies. Here, we describe the results of a retrospective clinical analysis establishing the effect of donor KIR motifs on the outcomes of 119 HLA-matched, unrelated donor HCT for adult acute myeloid leukaemia (AML) using myeloablative conditioning (MAC) in a predominantly T-cell deplete (TCD) cohort. We observed that HCT involving donors with at least one KIR B haplotype were more likely to result in non-relapse mortality (NRM) than HCT involving donors with two KIR A haplotypes (p = 0.019). Upon separation of KIR haplotypes into their centromeric (Cen) and telomeric (Tel) motif structures, we demonstrated that the Cen-B motif was largely responsible for this effect (p = 0.001). When the cause of NRM was investigated further, infection was the dominant cause of death (p = 0.006). No evidence correlating donor KIR B haplotype with relapse risk was observed. The results from this analysis confirm previous findings in the unrelated, TCD, MAC transplant setting and imply a protective role for donor-encoded Cen-A motifs against infection in allogeneic HCT recipients