Reproductive Freedom in the United States and Louisiana: An Assessment of the Last Decade, a Review of the Current Climate, And a Scenario for the Future

Government began legislating abortion in the mid nineteenth century and has controlled access to this service for women ever since. With the creation of hospital boards after WWII, state control over access became further entrenched. Regulations and restrictions since Roe v. Wade limit the availability of abortion services for women served by Medicaid and other social assistance programs. The existence of a class bias around access can be seen throughout the topic\u27s history and legislation has unfairly targeted and therefore disproportionately affects poor women. The data show that these restrictions have no impact on the number of unintended pregnancies over the last 20 plus years. Without the ability to personally fund the procedure, poor women do not enjoy the same choices as women in other social classes. In the next decade, we are likely to experience more of the same without having a realistic conversation about Medicaid funding of abortion

Reproductive Freedom in the United States and Louisiana: An Assessment of the Last Decade, a Review of the Current Climate, And a Scenario for the Future

Government began legislating abortion in the mid nineteenth century and has controlled access to this service for women ever since. With the creation of hospital boards after WWII, state control over access became further entrenched. Regulations and restrictions since Roe v. Wade limit the availability of abortion services for women served by Medicaid and other social assistance programs. The existence of a class bias around access can be seen throughout the topic\u27s history and legislation has unfairly targeted and therefore disproportionately affects poor women. The data show that these restrictions have no impact on the number of unintended pregnancies over the last 20 plus years. Without the ability to personally fund the procedure, poor women do not enjoy the same choices as women in other social classes. In the next decade, we are likely to experience more of the same without having a realistic conversation about Medicaid funding of abortion

Working Together: Neuroscience-Based Support for Art Therapists and Clients to Co-Create

How has recent research on mirror neurons and embodied simulation informed the way we understand the therapeutic relationship? Can this neuroscience research help art therapists gain more insight into the advantages and disadvantages of co-creating artwork with clients in session? Through a systematic review of literature, this paper explores the mirror neuron and embodied simulation research as well as three important elements of the therapeutic relationship in order to provide knowledge about how neuroscience can help art therapists understand what we do from a neurobiological perspective. The researcher provides an in-depth investigation of empathy, transference, and countertransference and their foundations in the related neuroscience. This investigation also offers information for art therapists in an effort to provide greater insight about the pros and cons of creating artwork with clients during art therapy sessions, and how these practices may be understood in a neuroscience context

Indiana Bureau of Developmental Disability Services: Art Therapy Service Proposal for the BDDS Waiver

This document is a proposal to include art therapy in the Indiana Bureau of Developmental Disability Services waiver

Pulmonary drug delivery of antimicrobials and anticancer drugs using solid dispersions

It is well established that currently available inhaled drug formulations are associated with extremely low lung deposition. Currently available technologies alleviate this low deposition problem via mixing the drug with inert larger particles, such as lactose monohydrate. Those inert particles are retained in the inhalation device or impacted in the throat and swallowed, allowing the smaller drug particles to continue their journey towards the lungs. While this seems like a practical approach, in some formulations, the ratio between the carrier to drug particles can be as much as 30 to 1. This limitation becomes more critical when treating lung conditions that inherently require large doses of the drug, such as antibiotics and antivirals that treat lung infections and anticancer drugs. The focus of this review article is to review the recent advancements in carrier free technologies that are based on coamorphous solid dispersions and cocrystals that can improve flow properties, and help with delivering larger doses of the drug to the lungs

Implementing Electronic Tablet-Based Education of Acute Care Patients

Poor education-related discharge preparedness for patients with heart failure is believed to be a major cause of avoidable rehospitalizations. Technology-based applications offer innovative educational approaches that may improve educational readiness for patients in both inpatient and outpatient settings; however, a number of challenges exist when implementing electronic devices in the clinical setting. Implementation challenges include processes for "on-boarding" staff, mediating risks of cross-contamination with patients' device use, and selling the value to staff and health system leaders to secure the investment in software, hardware, and system support infrastructure. Strategies to address these challenges are poorly described in the literature. The purpose of this article is to present a staff development program designed to overcome challenges in implementing an electronic, tablet-based education program for patients with heart failure

MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells

Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epithelial-mesenchymal transition (EMT). Here, we show that MAP3K4 controls the activity of the histone acetyltransferase CBP, and that acetylation of histones H2A and H2B by CBP is required to maintain the epithelial phenotype. Combined loss of MAP3K4/CBP activity represses expression of epithelial genes and causes TS cells to undergo EMT while maintaining their self-renewal and multipotency properties. The expression profile of MAP3K4 deficient TS cells defines an H2B acetylation regulated gene signature that closely overlaps with that of human breast cancer cells. Taken together, our data define an epigenetic switch that maintains the epithelial phenotype in TS cells and reveal previously unrecognized genes potentially contributing to breast cancer

Characterizing Dynamic Changes in the Human Blood Transcriptional Network

Gene expression data generated systematically in a given system over multiple time points provides a source of perturbation that can be leveraged to infer causal relationships among genes explaining network changes. Previously, we showed that food intake has a large impact on blood gene expression patterns and that these responses, either in terms of gene expression level or gene-gene connectivity, are strongly associated with metabolic diseases. In this study, we explored which genes drive the changes of gene expression patterns in response to time and food intake. We applied the Granger causality test and the dynamic Bayesian network to gene expression data generated from blood samples collected at multiple time points during the course of a day. The simulation result shows that combining many short time series together is as powerful to infer Granger causality as using a single long time series. Using the Granger causality test, we identified genes that were supported as the most likely causal candidates for the coordinated temporal changes in the network. These results show that PER1 is a key regulator of the blood transcriptional network, in which multiple biological processes are under circadian rhythm regulation. The fasted and fed dynamic Bayesian networks showed that over 72% of dynamic connections are self links. Finally, we show that different processes such as inflammation and lipid metabolism, which are disconnected in the static network, become dynamically linked in response to food intake, which would suggest that increasing nutritional load leads to coordinate regulation of these biological processes. In conclusion, our results suggest that food intake has a profound impact on the dynamic co-regulation of multiple biological processes, such as metabolism, immune response, apoptosis and circadian rhythm. The results could have broader implications for the design of studies of disease association and drug response in clinical trials