SIT 45: An interacting, compact, and star-forming isolated galaxy triplet

Acknowledgements. We thank our referee whose valuable comments have certainly contributed to improve and clarify this paper. MAF and PVB acknowledge financial support by the DI-PUCV research project 039.481/2020. MAF also acknowledges support from FONDECYT iniciación project 11200107 and the Emergia program (EMERGIA20_38888) from Consejería de Transformación Económica, Industria, Conocimiento y Universidades and University of Granada. UL and DE acknowledge support from project PID2020-114414GB- 100, financed by MCIN/AEI/10.13039/501100011033. DE also acknowledges support from Beatriz Galindo senior fellowship (BG20/00224) financed by the Spanish Ministry of Science and Innovation, and project PID2020-114414GB- 100 financed by MCIN/AEI/10.13039/501100011033. UL, SV and DE acknowledge support from project P20_00334 financed by the Junta de Andalucía and from FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Proyecto A-FQM-510-UGR20. MB gratefully acknowledges support by the ANID BASAL project FB210003 and from the FONDECYT regular grant 1211000. SDP is grateful to the Fonds de Recherche du Québec – Nature et Technologies and acknowledges financial support from the Spanish Ministerio de Economía y Competitividad under grants AYA2016-79724-C4-4-P and PID2019-107408GB-C44, from Junta de Andalucía Excellence Project P18-FR-2664, and also acknowledges support from the State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709). This research made use of Astropy, a community-developed core Python (http://www.python.org) package for Astronomy (Astropy Collaboration 2013); Ipython (Pérez & Granger 2007); Matplotlib (Hunter 2007); Numpy (Walt et al. 2011); Scipy (Jones et al. 2001); and Topcat (Taylor 2005). This research made use of Astrodendro, a Python package to compute dendrograms of Astronomical data (http:// www.dendrograms.org/). This research has made use of the NASA/IPAC Extragalactic Database, operated by the Jet Propulsion Laboratory of the California Institute of Technology, un centract with the National Aeronautics and Space Administration. Funding for SDSS-III has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the National Science Foundation, and the U.S. Department of Energy O ce of Science. The SDSS-III Web site is http://www.sdss3.org/. The SDSS-IV site is http://www.sdss. org. Based on observations made with the NASA Galaxy Evolution Explorer (GALEX). GALEX is operated for NASA by the California Institute of Technology under NASA contract NAS5-98034. This publication makes use of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory /California Institute of Technology, funded by the National Aeronautics and Space Administration.Context. The underlying scenario of the formation and evolution of galaxy triplets is still uncertain. Mergers of galaxies in isolated triplets give us the opportunity to study the already complex merging process, with minimal contamination of other environmental effects that potentially allow and accelerate galaxy transitions from active star-forming to passive galaxies. Aims. The merging system SIT 45 (UGC 12589) is one of 315 systems in the SDSS-based catalogue of Isolated Triplets (SIT); it is an unusual isolated galaxy triplet, consisting of three merging late-type galaxies. The main aims of this work are to study the dynamical evolution and star formation history (SFH) of SIT 45, as well as its dependence on its local and large-scale environment. Methods. To study its dynamics, parameters such as the velocity dispersion (σv), the harmonic radius (RH), the crossing time (H0tc), and the virial mass (Mvir), along with the compactness of the triplet (S) were considered. To investigate the possible dependence of these dynamical parameters on the environment, the tidal force Q parameters (both local and large-scale) and the projected local density (ηk) were used. To constrain the SFH, we used CIGALE to fit its observed spectral energy distribution using multiwavelength data from the ultraviolet to the infrared. Results. SIT 45 is one of the most compact triplets in the SIT, and it is also more compact than triplets in other samples. According to its SFH, SIT 45 presents star formation, where the galaxies also present recent (∼200 Myr) star formation increase, indicating that this activity may have been triggered by the interaction. Its dynamical configuration suggests that the system is highly evolved in comparison to the SIT. However, this is not expected for systems composed of star-forming late-type galaxies, based on observations in compact groups. Conclusions. We conclude that SIT 45 is a system of three interacting galaxies that are evolving within the same dark matter halo; its compact configuration is a consequence of the ongoing interaction rather than being due to a long-term evolution (as suggested from its H0tc value). We consider two scenarios for the present configuration of the triplet, one where one of the members is a tidal galaxy, and another where this galaxy arrives to the system after the interaction. Both scenarios need further exploration. The isolated triplet SIT 45 is therefore an ideal system to study short timescale mechanisms (∼108 yr), such as starbursts triggered by interactions which are more frequent at higher redshift.DI-PUCV research project 039.481/2020FONDECYT iniciación project 11200107Emergia program (EMERGIA20_38888) from Consejería de Transformación Económica, Industria, Conocimiento y UniversidadesUniversity of GranadaProject PID2020-114414GB- 100, financed by MCIN/AEI/10.13039/501100011033Senior fellowship (BG20/00224) financed by the Spanish Ministry of Science and InnovationProject PID2020-114414GB- 100 financed by MCIN/AEI/10.13039/501100011033Project P20_00334 financed by the Junta de Andalucía and from FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Proyecto A-FQM-510-UGR20ANID BASAL project FB210003FONDECYT regular grant 1211000Fonds de Recherche du Québec – Nature et TechnologiesSpanish Ministerio de Economía y Competitividad under grants AYA2016-79724-C4-4-P and PID2019-107408GB-C44Junta de Andalucía Excellence Project P18-FR-2664State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709

SIT 45: An interacting, compact, and star-forming isolated galaxy triplet

The merging system SIT 45 (UGC 12589) is an unusual isolated galaxy triplet, consisting of three merging late-type galaxies, out of 315 systems in the SIT (SDSS-based catalogue of Isolated Triplets). The main aims of this work are to study its dynamical evolution and star formation history (SFH), as well as its dependence on its local and large-scale environment. To study its dynamics, parameters such as the velocity dispersion ($\sigma_{v}$), the harmonic radius ($R_{H}$), the crossing time ($H_0t_c$), and the virial mass ($M_{vir}$), along with the compactness of the triplet ($S$) were considered. To constrain the SFH, we used CIGALE to fit its observed spectral energy distribution using multi-wavelength data from the ultraviolet to the infrared. According to its SFH, SIT 45 presents star-formation, where the galaxies also present recent ($\sim$200 Myr) star-formation increase, indicating that this activity may have been triggered by the interaction. Its dynamical configuration suggests that the system is highly evolved in comparison to the SIT. However this is not expected for systems composed of star-forming late-type galaxies, based on observations in compact groups. We conclude that SIT 45 is a system of three interacting galaxies that are evolving within the same dark matter halo, where its compact configuration is a consequence of the on-going interaction, rather than due to a long-term evolution (as suggested from its $H_0t_c$ value). We consider two scenarios for the present configuration of the triplet, one where one of the members is a tidal galaxy, and another where this galaxy arrives to the system after the interaction. Both scenarios need further exploration. The isolated triplet SIT 45 is therefore an ideal system to study short timescale mechanisms ($\sim 10^8$ years), such as starbursts triggered by interactions which are more frequent at higher redshift.Comment: 13 pages, 7 figures, accepted for publication in Astronomy & Astrophysic

Understanding the role of morphology and environment in the dynamical evolution of isolated galaxy triplets

Context. The environments where galaxies reside affects their evolutionary histories. Galaxy triplets (systems composed of three physically bound galaxies) are one of simplest groups of galaxies, and are therefore excellent laboratories to study evolutionary mechanisms where effects of the environment are minimal. Aims. We present a statistical study of the dynamical properties of isolated galaxy triplets as a function of their local and large-scale environments. To explore the connection of the dynamical evolution on the systems with the evolution of the galaxies composing the triplets, we consider observational properties such as morphology and star formation rate (SFR). Methods. We used the SDSS-based catalogue of Isolated Triplets (SIT), which contains 315 triplets. We classified each triplet ac cording to galaxy morphologies and defined a parameter Qtrip to quantify the total local tidal strengths in the systems. To quantify the dynamical stage of the system we used the parameters of harmonic radius RH, velocity dispersion σvr , crossing time H0tc , and virial mass Mvir. Results. Triplets composed of three early-type galaxies present the smallest RH, indicating that they are in general more compact than triplets with one or more late-type galaxies. Among triplets with low values of RH and H0tc , SIT triplets with Qtrip < −2 are relaxed systems that are more dynamically evolved, while triplets with Qtrip > −2 show compact configurations due to interactions within the system, such as ongoing mergers. Conclusions. We found that there is no dominant galaxy in triplets in terms of properties of stellar populations such as global colour and SFR. Moreover, the global SFR in isolated triplets composed of two or more early-type galaxies increases with the stellar mass ratio of the galaxies with respect to the central galaxy, therefore the system is globally ‘rejuvenated’DI-PUCV research project 039.481/2020Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 11200107Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades EMERGIA20_38888University of GranadaJunta de Andalucia P20_00334FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades A-FQM-510-UGR20Spanish Government AYA2016-79724-C4-4-P PID2019-107408GB-C44Junta de Andalucia P18-FR-2664Spanish Government SEV-2017-0709Alfred P. Sloan FoundationNational Science Foundation (NSF)United States Department of Energy (DOE)National Aeronautics & Space Administration (NASA) NAS5-9803

SIT 45: An interacting, compact, and star-forming isolated galaxy triplet

This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Context. The underlying scenario of the formation and evolution of galaxy triplets is still uncertain. Mergers of galaxies in isolated triplets give us the opportunity to study the already complex merging process, with minimal contamination of other environmental effects that potentially allow and accelerate galaxy transitions from active star-forming to passive galaxies. Aims. The merging system SIT 45 (UGC 12589) is one of 315 systems in the SDSS-based catalogue of Isolated Triplets (SIT); it is an unusual isolated galaxy triplet, consisting of three merging late-type galaxies. The main aims of this work are to study the dynamical evolution and star formation history (SFH) of SIT 45, as well as its dependence on its local and large-scale environment. Methods. To study its dynamics, parameters such as the velocity dispersion (σv), the harmonic radius (RH), the crossing time (H0tc), and the virial mass (Mvir), along with the compactness of the triplet (S) were considered. To investigate the possible dependence of these dynamical parameters on the environment, the tidal force Q parameters (both local and large-scale) and the projected local density (ηk) were used. To constrain the SFH, we used CIGALE to fit its observed spectral energy distribution using multiwavelength data from the ultraviolet to the infrared. Results. SIT 45 is one of the most compact triplets in the SIT, and it is also more compact than triplets in other samples. According to its SFH, SIT 45 presents star formation, where the galaxies also present recent (∼200 Myr) star formation increase, indicating that this activity may have been triggered by the interaction. Its dynamical configuration suggests that the system is highly evolved in comparison to the SIT. However, this is not expected for systems composed of star-forming late-type galaxies, based on observations in compact groups. Conclusions. We conclude that SIT 45 is a system of three interacting galaxies that are evolving within the same dark matter halo; its compact configuration is a consequence of the ongoing interaction rather than being due to a long-term evolution (as suggested from its H0tc value). We consider two scenarios for the present configuration of the triplet, one where one of the members is a tidal galaxy, and another where this galaxy arrives to the system after the interaction. Both scenarios need further exploration. The isolated triplet SIT 45 is therefore an ideal system to study short timescale mechanisms (∼108 yr), such as starbursts triggered by interactions which are more frequent at higher redshift. © The Authors 2022.MAF and PVB acknowledge financial support by the DI-PUCV research project 039.481/2020. MAF also acknowledges support from FONDECYT iniciación project 11200107 and the Emergia program (EMERGIA20_38888) from Consejería de Transformación Económica, Industria, Conocimiento y Universidades and University of Granada. UL and DE acknowledge support from project PID2020-114414GB-100, financed by MCIN/AEI/10.13039/501100011033. DE also acknowledges support from Beatriz Galindo senior fellowship (BG20/00224) financed by the Spanish Ministry of Science and Innovation, and project PID2020-114414GB-100 financed by MCIN/AEI/10.13039/501100011033. UL, SV and DE acknowledge support from project P20_00334 financed by the Junta de Andalucía and from FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Proyecto A-FQM-510-UGR20. MB gratefully acknowledges support by the ANID BASAL project FB210003 and from the FONDECYT regular grant 1211000. SDP is grateful to the Fonds de Recherche du Québec – Nature et Technologies and acknowledges financial support from the Spanish Ministerio de Economía y Competitividad under grants AYA2016-79724-C4-4-P and PID2019-107408GB-C44, from Junta de Andalucía Excellence Project P18-FR-2664, and also acknowledges support from the State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709). This research made use of ASTROPY, a community-developed core PYTHON (http://www.python.org) package for Astronomy (Astropy Collaboration 2013); IPYTHON (Pérez & Granger 2007); MATPLOTLIB (Hunter 2007); NUMPY (Walt et al. 2011); SCIPY (Jones et al. 2001); and TOPCAT (Taylor 2005). This research made use of ASTRODENDRO, a Python package to compute dendrograms of Astronomical data (http://www.dendrograms.org/). This research has made use of the NASA/IPAC Extragalactic Database, operated by the Jet Propulsion Laboratory of the California Institute of Technology, un centract with the National Aeronautics and Space Administration. Funding for SDSS-III has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the National Science Foundation, and the U.S. Department of Energy Office of Science. The SDSS-III Web site is http://www.sdss3.org/. The SDSS-IV site is http://www.sdss.org. Based on observations made with the NASA Galaxy Evolution Explorer (GALEX). GALEX is operated for NASA by the California Institute of Technology under NASA contract NAS5-98034. This publication makes use of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).Peer reviewe

Cytochrome c: Using Biological Insight toward Engineering an Optimized Anticancer Biodrug

The heme protein cytochrome c (Cyt c) plays pivotal roles in cellular life and death processes. In the respiratory chain of mitochondria, it serves as an electron transfer protein, contributing to the proliferation of healthy cells. In the cell cytoplasm, it activates intrinsic apoptosis to terminate damaged cells. Insight into these mechanisms and the associated physicochemical properties and biomolecular interactions of Cyt c informs on the anticancer therapeutic potential of the protein, especially in its ability to subvert the current limitations of small molecule-based chemotherapy. In this review, we explore the development of Cyt c as an anticancer drug by identifying cancer types that would be receptive to the cytotoxicity of the protein and factors that can be finetuned to enhance its apoptotic potency. To this end, some information is obtained by characterizing known drugs that operate, in part, by triggering Cyt c induced apoptosis. The application of different smart drug delivery systems is surveyed to highlight important features for maintaining Cyt c stability and activity and improving its specificity for cancer cells and high drug payload release while recognizing the continuing limitations. This work serves to elucidate on the optimization of the strategies to translate Cyt c to the clinical market

II Consenso Colombiano para el Manejo de la Osteoporosis Posmenopáusica

The Colombian Osteoporosis and Mineral Metabolism Association met in early 2017 to update the Colombian Consensus on Osteoporosis. This was first issued in 2005, and is seen as a necessary step in view of the underdiagnosed status of this disease, and the expected impact of population ageing. A technical team was formed with specialists with long experience across multiple disciplines, who were assigned to four working groups: definitions and epidemiology, diagnosis, pharmacological treatment, and non-pharmacological treatment. After a scientific literature review and a series of meetings, the definitions and recommendations are summarised in this article. © 2018 Asociación Colombiana de Reumatologí

II Consenso Colombiano para el Manejo de la Osteoporosis Posmenopáusica

The Colombian Osteoporosis and Mineral Metabolism Association met in early 2017 to update the Colombian Consensus on Osteoporosis. This was first issued in 2005, and is seen as a necessary step in view of the underdiagnosed status of this disease, and the expected impact of population ageing. A technical team was formed with specialists with long experience across multiple disciplines, who were assigned to four working groups: definitions and epidemiology, diagnosis, pharmacological treatment, and non-pharmacological treatment. After a scientific literature review and a series of meetings, the definitions and recommendations are summarised in this article. © 2018 Asociación Colombiana de Reumatologí