“That means nothing to me as a normal person who doesn\u27t know about patents”: Usability testing of Google Patents and Patent Public Search with undergraduate engineering students

Patent searching is an important research tool for undergraduate engineering students, yet it requires special topic knowledge to conduct successfully. Patent database websites have the ability to alleviate or add to the complexity of patent searching, depending on their usability. Prompted by the launch of the US Patent and Trademark Office’s Patent Public Search (PPS) website in early 2022, the authors investigated the usability of PPS and Google Patents. The study\u27s objective was to gain insights into the ways in which the websites of commonly-used patent databases support undergraduate students’ patent searching activities. The study examined students’ performance of typical tasks such as constructing search queries, filtering results, evaluating results, and interpreting classification and citation data. Data was collected via moderated in-person usability testing, following a think-aloud protocol. Usability issues were identified in both websites, though participants unanimously preferred Google Patents due to their familiarity with other Google products and the “cleaner” design of the search interface. Based on the study’s results, the authors offer recommendations for patent literacy instruction for undergraduate students

“That means nothing to me as a normal person who doesn\u27t know about patents”: Usability testing of Google Patents and Patent Public Search with undergraduate engineering students

Patent searching is an important research tool for undergraduate engineering students, yet it requires special topic knowledge to conduct successfully. Patent database websites have the ability to alleviate or add to the complexity of patent searching, depending on their usability. Prompted by the launch of the US Patent and Trademark Office’s Patent Public Search (PPS) website in early 2022, the authors investigated the usability of PPS and Google Patents. The study\u27s objective was to gain insights into the ways in which the websites of commonly-used patent databases support undergraduate students’ patent searching activities. The study examined students’ performance of typical tasks such as constructing search queries, filtering results, evaluating results, and interpreting classification and citation data. Data was collected via moderated in-person usability testing, following a think-aloud protocol. Usability issues were identified in both websites, though participants unanimously preferred Google Patents due to their familiarity with other Google products and the “cleaner” design of the search interface. Based on the study’s results, the authors offer recommendations for patent literacy instruction for undergraduate students

Does Native Plant Density Matter for Coastal/shrub Habitat Restoration in the Presence of Non-native Invasive Species?

Coastal forests play a crucial role in maintaining biodiversity and providing habitats for many species of migratory birds and pollinators. We tested if a closed canopy provided by a restored coastal forest will provide enough shade to reduce the invasive population of mugwort (Artemisia vulgaris). Mugwort has little value to wildlife as it’s pollen and tiny seeds are wind dispersed. It grows densely and frequently out competes native plant species. Native tree and shrub species were planted close together (~1m apart) in 2017 and 2019 on a remediated site in Stratford, Connecticut. The 0.52 ha area was covered with mugwort in 2017 and mowed; the native trees and shrubs came in 3-gallon containers from a local nursery. By 2022, approximately 0.39 ha is covered with tree and shrub canopy. Thus, 75% of the forest area is populated with native species instead of mugwort. This restoration has significantly decreased the population of mugwort to only 25% of the area. We also observed an increase in pollinating insects and this small patch of coastal forest serves as a stopover site for migrating passerines. Restoration of coastal forests and reduction of invasive plants can be accomplished in four years with highly dense plantings

"Besides life here" by Molly Graham, "Chuck Lakin, woodworker" by Molly Jean Bennett, "Tongues twisting" by Judith Sloan, and "Food for thought" by Mark Munger

PodcastMolly Graham, Molly Jean Bennett, Judith Sloan and Mark Munger are The Missouri Review's 2011 runners-up in the self-recorded documentary category. This podcast features readings by all four authors

Rescuing Qualia

Daniel Dennett provides many compelling reasons to question the existence of phenomenal experiences in his paper titled Quining Qualia, however, from the perspective of the individual, qualia appear to be an inherent feature of consciousness. The act of reflecting on one’s experiences suggests that subjective feelings and sensations are a necessary element of human life, as personal opinions on various artistic works are apt to demonstrate. This paper argues that by considering subjective experiences from a naturalized functionalist perspective, a comprehensive explanation for qualia can be provided given its origins in evolutionary biology. As information passing through the nervous system, qualia serve to guide the behaviour of individuals to ultimately facilitate survival. Specifically, qualia are representations of environmental features, existing as information messages supported by neural physiology and encoded in electrochemical formats. In addition to addressing the Hard Problem of Consciousness and clarifying the four properties Dennett associates with qualia, this theoretical foundation enables further metaphysical discussion on the nature of consciousness more generally. Although many outstanding questions on the contents of subjective experiences are apt to linger given the explanatory gap, a robust theory for the existence of qualia can be developed through the integration of ideas and concepts from a variety of domains

Interventional Systems Ethnography and Intersecting Injustices: A New Approach for Fostering Reciprocal Community Engagement

Effectively addressing wicked problems requires collaborative, embedded action. But, in many cases, scholarly commitments, social justice, privilege, and precarity collide in ways that make it difficult for community-engaged scholars to ethically navigate competing duties. This article presents our efforts to support reciprocal community engagement in addressing cancer- obesity comorbidity and risk coincidence in underserved communities. Partnering with community healthcare professionals, we conducted an adapted Systems Ethnography/Qualitative Modeling (SEQM) study. SEQM offers an alternative ethical framework for community-engaged research, one that supports reciprocity through enabling participant-centered community self-definition, goal setting, and solution identification

Broad-Scale Recombination Patterns Underlying Proper Disjunction in Humans

Although recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees. Our analysis supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunction, with additional chiasmata occurring in proportion to physical length. The requirement is not absolute, however, as chromosome 21 seems to be frequently transmitted properly in the absence of a chiasma in females, a finding that raises the possibility of a back-up mechanism aiding in its correct segregation. We also found a set of double crossovers in surprisingly close proximity, as expected from a second pathway that is not subject to crossover interference. These findings point to multiple mechanisms that shape the distribution of crossovers, influencing proper disjunction in humans.</p

Refining the risk of HTLV-1-associated myelopathy in people living with HTLV-1: identification of a HAM-like phenotype in a proportion of asymptomatic carriers

Up to 3.8% of human T-lymphotropic virus type-1 (HTLV-1)-infected asymptomatic carriers (AC) eventually develop HTLV-1-associated myelopathy (HAM). HAM occurs in patients with high (> 1%) HTLV proviral load (PVL). However, this cut-off includes more than 50% of ACs and therefore the risk needs to be refined. As HAM is additionally characterised by an inflammatory response to HTLV-1, markers of T cell activation (TCA), β2-microglobulin (β2M) and neuronal damage were accessed for the identification of ACs at high risk of HAM. Retrospective analysis of cross-sectional and longitudinal routine clinical data examining differences in TCA (CD4/CD25, CD4/HLA-DR, CD8/CD25 & CD8/HLA-DR), β2M and neurofilament light (NfL) in plasma in ACs with high or low PVL and patients with HAM. Comparison between 74 low PVL ACs, 84 high PVL ACs and 58 patients with HAM revealed a significant, stepwise, increase in TCA and β2M. Construction of receiver operating characteristic (ROC) curves for each of these blood tests generated a profile that correctly identifies 88% of patients with HAM along with 6% of ACs. The 10 ACs with this 'HAM-like' profile had increased levels of NfL in plasma and two developed myelopathy during follow-up, compared to none of the 148 without this viral-immune-phenotype. A viral-immuno-phenotype resembling that seen in patients with HAM identifies asymptomatic carriers who are at increased risk of developing HAM and have markers of subclinical neuronal damage

A randomized trial comparing skin antiseptic agents at Cesarean delivery

BACKGROUND: Preoperative skin antisepsis has the potential to decrease the risk of surgical-site infection. However, evidence is limited to guide the choice of antiseptic agent at cesarean delivery, which is the most common major surgical procedure among women in the United States. METHODS: In this single-center, randomized, controlled trial, we evaluated whether the use of chlorhexidine–alcohol for preoperative skin antisepsis was superior to the use of iodine–alcohol for the prevention of surgical-site infection after cesarean delivery. We randomly assigned patients undergoing cesarean delivery to skin preparation with either chlorhexidine–alcohol or iodine–alcohol. The primary outcome was superficial or deep surgical-site infection within 30 days after cesarean delivery, on the basis of definitions from the Centers for Disease Control and Prevention. RESULTS: From September 2011 through June 2015, a total of 1147 patients were enrolled; 572 patients were assigned to chlorhexidine–alcohol and 575 to iodine–alcohol. In an intention-to-treat analysis, surgical-site infection was diagnosed in 23 patients (4.0%) in the chlorhexidine–alcohol group and in 42 (7.3%) in the iodine–alcohol group (relative risk, 0.55; 95% confidence interval, 0.34 to 0.90; P = 0.02). The rate of superficial surgical-site infection was 3.0% in the chlorhexidine–alcohol group and 4.9% in the iodine–alcohol group (P = 0.10); the rate of deep infection was 1.0% and 2.4%, respectively (P = 0.07). The frequency of adverse skin reactions was similar in the two groups. CONCLUSIONS: The use of chlorhexidine–alcohol for preoperative skin antisepsis resulted in a significantly lower risk of surgical-site infection after cesarean delivery than did the use of iodine–alcohol. (Funded by the National Institutes of Health and Washington University School of Medicine in St. Louis; ClinicalTrials.gov number, NCT01472549.