The Isolation and Identification of Two Antifungal Pterocarpans from Ulex Europaeus L.

The isolation of two antifungal pterocarpans from the roots of Ulex europaeus L (Leguminosae) is described. The compounds were identified as 3-hydroxy 8,9-methylenedioxypterocarpan(maackiain)and 2-hydroxy-3,4dimethoxy- 8, 9-methylenedioxypterocarpan (2-hydroxy-4-methoxypterocarpin) by spectroscopic methods

Daring to speak the truth: de-constructing and re-constructing reconciliation

Reconciliation has been on the political agenda in Australia since the early 1990s and is now planted firmly in the public conscience. Australia celebrates reconciliation every year; political leaders talk often about reconciliation; schools teach reconciliation. Yet, if you take as performance indicators the gap in life expectancy, or the increasingly disproportionate numbers of Aboriginal and Torres Strait Islander people in prison, one has to question whether Australia is walking further away from the work that is needed to heal and achieve true reconciliation. In this paper we will draw on our experiences of working within church and education contexts and critically engage with the challenges and limitations of reconciliation as we have encountered them. We suggest that it is necessary to talk about reconciliation in terms of a human rights agenda and make explicit the connections between reconciliation and policy and practices. As Lowitja O’Donoghue has said, “we must accept the truth of our history – it is the truth that will set us free”. But how do we dare to speak the truth when the dominant political discourse focuses on the perceived success of reconciliation?

Demographic associations with stage of readiness to screen for colorectal cancer

Objective: To describe the distribution of a population in southern urban Adelaide in terms of readiness to screen for colorectal cancer (CRC) by Faecal Occult Blood Test (FOBT) or colonoscopy according to the stages in the Transtheoretical Model (TTM) of behaviour change and to compare the stages according to demographic variables. Methods: A random sample of 664 South Australians aged 50 to 74 were surveyed in June 2006. Chi-squared analyses were performed to determine if statistically significant differences on demographic variables existed between participants at different stages of readiness to screen

Novel biomarkers for risk stratification of Barrett's oesophagus associated neoplastic progression-epithelial HMGB1 expression and stromal lymphocytic phenotype

The preparation of this paper was funded in part by the Pathological Society of Great Britain and Ireland (intercalated degree educational studentship to R.J.P.). All data is published within this paper and within accompanying supporting files (indicated in text) and accessed via weblink on the journal site.Peer reviewedPublisher PD

Exploring the Validity of the Continuum of Resistance Model for Discriminating Early from Late and Non-uptake of Colorectal Cancer Screening: Implications for the Design of Invitation and Reminder Letters.

This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy.Background The continuum of resistance model contends that respondents lie at one end of a continuum and non-respondents at the other with respect to factors demonstrated to impact on screening participation. Purpose The aim of this study was to explore the validity of this model for the prediction of participation in colorectal cancer screening. Method People aged 50 to 74 years were asked to complete a survey (n = 1,250). Eligible respondents (n = 376, 30 %) were invited to complete a faecal occult blood test (FOBT). The cutoff period for the determination of participation rates was 12 weeks, with a reminder sent at 6 weeks. Results FOBTs were returned by n = 196 people (132 within 6 weeks, 64 following a reminder). Participation was generally influenced by the same variables in both the first 6 weeks and the second 6 weeks, consistent with the continuum of resistance model. These variables were having known someone with bowel cancer and the social cognitive factor, perceptions of barriers to screening. There is a suggestion, however, that other factors may be differentially associated with early, late and non-participants. Conclusion Participation in screening appears somewhat consistent with the continuum of resistance model in that early and late participants respond to some of the same factors. This suggests that the same messages are relevant to early, late and non-screeners, but further consideration of what other factors may be influencing discrete stages of readiness to participate is necessary.This work was supported by a National Health and Medical Research Council Grant number 324717

Contrast-enhanced ultrasound and/or colour duplex ultrasound for surveillance after endovascular abdominal aortic aneurysm repair : a systematic review and economic evaluation

Study registration: This study is registered as PROSPERO CRD42016036475. Funding: The National Institute for Health Research Health Technology Assessment programme.Peer reviewedPublisher PD

A PAR-1–dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte

A PAR-1–mediated bias in microtubule organization in the Drosophila oocyte underlies posterior-directed mRNA transport

Colorectal cancer screening in rural and remote areas: analysis of the National Bowel Cancer Screening Program data for South Australia.

In Australia, colorectal cancer is the second most commonly diagnosed cancer and cause of death from malignant diseases, and its incidence is rising. The aim of this article was to present an analysis of National Bowel Cancer Screening Program (NBCSP) data for rural and remote South Australia (SA), in order to identify geographical areas and population groups that may benefit from targeted approaches to increase participation rates in colorectal cancer screening.The findings of this study suggest lower NBCSP participation rates for people from metropolitan and remote areas, compared with those from rural areas. The uptake of cancer screening is lower for older rural and remote residents, men, Indigenous people, lower socioeconomic groups and those living in the Far North subdivision of SA