1,071 research outputs found
Changes in Cross-Sectional Area of Spinal Canal and Vertebral Body Under 2 Years of Teriparatide Treatment: Results from the EUROFORS Study
The treatment of osteoporotic patients with teriparatide is associated with a significant increase in bone formation and gain of bone mass. The purpose of this post hoc analysis was to determine if the cross-sectional area (CSA) of the spinal canal and the vertebral body is affected by teriparatide treatment. Narrowing of the spinal canal might represent a safety problem, while widening of the vertebral CSA might improve mechanical stability. High-resolution computed tomography (HRCT) scans of vertebra T12 were obtained at baseline and after 6, 12, and 24Â months of teriparatide treatment (20Â Îźg/day) from 44 postmenopausal women with established osteoporosis participating in the prospective, randomized EUROFORS study. The CSA of the spinal canal did not decrease but increased marginally by 0.9% (2.6Â mm2) over 24Â months (PÂ <Â 0.001), with a range from â0.5% (â2Â mm2) to 3.1% (+8Â mm2). Even when analyzing the spinal CSA on a slice-by-slice basis, no clinically relevant narrowing of the spinal canal was observed. For vertebral bodies, the CSA increased by 0.7% (5.7Â mm2) over 24Â months (PÂ <Â 0.001), with a range from â0.4% (â3Â mm2) to 1.6% (+14Â mm2). Our data do not provide evidence for safety concerns regarding spinal canal narrowing. On the other hand, the increases observed for vertebral CSA apparently also only minimally contribute to the mechanical strengthening of the vertebral body under teriparatide treatment
Gate-Controlled Electron Spin Resonance in a GaAs/AlGaAs Heterostructure
The electron spin resonance (ESR) of two-dimensional electrons is
investigated in a gated GaAs/AlGaAs heterostructure. We found that the ESR
resonance frequency can be turned by means of a gate voltage. The front and
back gates of the heterostructure produce opposite g-factor shift, suggesting
that electron g-factor is being electrostatically controlled by shifting the
equilibrium position of the electron wave function from one epitaxial layer to
another with different g-factors
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