3,917 research outputs found
Social Remittances and Social Change in Central and Eastern Europe: Embedding Migration in the Study of Society
Our article considers social remittances and social change in Central and Eastern Europe. We show
how migration scholarship can be embedded into the wider study of social processes and relations.
‘Social remitting’ sometimes seems to be little more than a slippery catchphrase; however, this article
defends the concept. If it is defined carefully and used cautiously, it should help the researcher to think
about what, in addition to money, is sent from one society to another and exactly how, thus shedding
light on important and insufficiently studied aspects of migration. A close-up view of the processes by
which ideas, practices, norms, values and, according to some definitions, social capital and social skills
are transferred by migrants across international borders helps researchers to understand more precisely how migration contributes to social change or, in some cases, prevents it from occurring. Our
article reviews some of the most interesting arguments and findings presented recently by other scholars
and discusses aspects of social remitting which particularly interested us in our own research. The
context of our research is social change in Poland: we attempt to understand how migration has contributed to wider patterns of social change since 1989 and exactly how it intertwines with other social
trends and globalisation influences. This entails a careful focus on both structural conditions and
agency and therefore on social remittances
Modular classes of skew algebroid relations
Skew algebroid is a natural generalization of the concept of Lie algebroid.
In this paper, for a skew algebroid E, its modular class mod(E) is defined in
the classical as well as in the supergeometric formulation. It is proved that
there is a homogeneous nowhere-vanishing 1-density on E* which is invariant
with respect to all Hamiltonian vector fields if and only if E is modular, i.e.
mod(E)=0. Further, relative modular class of a subalgebroid is introduced and
studied together with its application to holonomy, as well as modular class of
a skew algebroid relation. These notions provide, in particular, a unified
approach to the concepts of a modular class of a Lie algebroid morphism and
that of a Poisson map.Comment: 20 page
The graded Jacobi algebras and (co)homology
Jacobi algebroids (i.e. `Jacobi versions' of Lie algebroids) are studied in
the context of graded Jacobi brackets on graded commutative algebras. This
unifies varios concepts of graded Lie structures in geometry and physics. A
method of describing such structures by classical Lie algebroids via certain
gauging (in the spirit of E.Witten's gauging of exterior derivative) is
developed. One constructs a corresponding Cartan differential calculus (graded
commutative one) in a natural manner. This, in turn, gives canonical generating
operators for triangular Jacobi algebroids. One gets, in particular, the
Lichnerowicz-Jacobi homology operators associated with classical Jacobi
structures. Courant-Jacobi brackets are obtained in a similar way and use to
define an abstract notion of a Courant-Jacobi algebroid and Dirac-Jacobi
structure. All this offers a new flavour in understanding the
Batalin-Vilkovisky formalism.Comment: 20 pages, a few typos corrected; final version to be published in J.
Phys. A: Math. Ge
Hamiltonian dynamics and constrained variational calculus: continuous and discrete settings
The aim of this paper is to study the relationship between Hamiltonian
dynamics and constrained variational calculus. We describe both using the
notion of Lagrangian submanifolds of convenient symplectic manifolds and using
the so-called Tulczyjew's triples. The results are also extended to the case of
discrete dynamics and nonholonomic mechanics. Interesting applications to
geometrical integration of Hamiltonian systems are obtained.Comment: 33 page
An anti-establishment backlash that shook up the party system? The October 2015 Polish parliamentary election
The October 2015 Polish parliamentary election saw the stunning victory of the right-wing opposition Law and Justice party which became the first in post-communist Poland to secure an outright parliamentary majority, and equally comprehensive defeat of the incumbent centrist Civic Platform. In addition to the fact that the outgoing ruling party could no longer rely on invoking the ‘politics of fear’, the main factor accounting for this was widespread disillusionment with the country’s ruling elite. The election also saw the broad ‘post-transition’ socio-demographic and ideological divide and Law and Justice-Civic Platform duopoly continuing to dominate party competition. However, there were some indications of greater party system fluidity and question marks over who would emerge as the main representative of the anti-Law and Justice side of this divide
Migration and diversity in a post-socialist context: Creating integrative encounters in Poland
This article explores ‘integrative encounters’ between immigrants and Polish people in Warsaw. Rather than focus on new arrivals we pay attention to the integration experiences of the host population in recognition that this is a group who have been relatively neglected in the literature. Post-socialist European countries where population mobility was circumscribed during the communist era and as a consequence became perceived as relatively homogenous white societies but which are now seeing a rise in immigration, have been largely neglected by non-domestic scholars. In Poland organised group activity is an important means to provide the established population with an opportunity to encounter migrants because such encounters are less likely to occur in everyday spaces. Drawing on research with a Warsaw based NGO which runs a football league to bring Polish people and immigrants together, we argue that attention needs to be paid to the issue of ‘motivation' to participate in integration projects and to the significance of sociality. In doing so, we suggest that creating the conditions for spontaneous connections to develop, even in contrived projects, is a way to overcome indifference to difference. Here, we highlight the qualities of football as a bridging activity to facilitate integrative encounters
Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers
\ua9 2022, The Author(s). Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have comprehensively evaluated Mre11 in epithelial ovarian cancers. In clinical cohort that received platinum- based chemotherapy (n = 331), Mre11 protein overexpression was associated with aggressive phenotype and poor progression free survival (PFS) (p = 0.002). In the ovarian cancer genome atlas (TCGA) cohort (n = 498), Mre11 gene amplification was observed in a subset of serous tumours (5%) which correlated highly with Mre11 mRNA levels (p < 0.0001). Altered Mre11 levels was linked with genome wide alterations that can influence platinum sensitivity. At the transcriptomic level (n = 1259), Mre11 overexpression was associated with poor PFS (p = 0.003). ROC analysis showed an area under the curve (AUC) of 0.642 for response to platinum-based chemotherapy. Pre-clinically, Mre11 depletion by gene knock down or blockade by small molecule inhibitor (Mirin) reversed platinum resistance in ovarian cancer cells and in 3D spheroid models. Importantly, Mre11 inhibition was synthetically lethal in platinum sensitive XRCC1 deficient ovarian cancer cells and 3D-spheroids. Selective cytotoxicity was associated with DNA double strand break (DSB) accumulation, S-phase cell cycle arrest and increased apoptosis. We conclude that pharmaceutical development of Mre11 inhibitors is a viable clinical strategy for platinum sensitization and synthetic lethality in ovarian cancer
Multijet production in neutral current deep inelastic scattering at HERA and determination of α_{s}
Multijet production rates in neutral current deep inelastic scattering have been measured in the range of exchanged boson virtualities 10 5 GeV and –1 < η_{LAB}^{jet} < 2.5. Next-to-leading-order QCD calculations describe the data well. The value of the strong coupling constant α_{s} (M_{z}), determined from the ratio of the trijet to dijet cross sections, is α_{s} (M_{z}) = 0.1179 ± 0.0013 (stat.)_{-0.0046}^{+0.0028}(exp.)_{-0.0046}^{+0.0028}(th.)
Performance deficits of NK1 receptor knockout mice in the 5 choice serial reaction time task: effects of d Amphetamine, stress and time of day.
Background
The neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD). Here we tested whether NK1R-/- mice express other core features of ADHD (impulsivity and inattentiveness) and, if so, whether they are diminished by d-amphetamine, as in ADHD. Prompted by evidence that circadian rhythms are disrupted in ADHD, we also compared the performance of mice that were trained and tested in the morning or afternoon.
Methods and Results
The 5-Choice Serial Reaction-Time Task (5-CSRTT) was used to evaluate the cognitive performance of NK1R-/- mice and their wildtypes. After training, animals were tested using a long (LITI) and a variable (VITI) inter-trial interval: these tests were carried out with, and without, d-amphetamine pretreatment (0.3 or 1 mg/kg i.p.). NK1R-/- mice expressed greater omissions (inattentiveness), perseveration and premature responses (impulsivity) in the 5-CSRTT. In NK1R-/- mice, perseveration in the LITI was increased by injection-stress but reduced by d-amphetamine. Omissions by NK1R-/- mice in the VITI were unaffected by d-amphetamine, but premature responses were exacerbated by this psychostimulant. Omissions in the VITI were higher, overall, in the morning than the afternoon but, in the LITI, premature responses of NK1R-/- mice were higher in the afternoon than the morning.
Conclusion
In addition to locomotor hyperactivity, NK1R-/- mice express inattentiveness, perseveration and impulsivity in the 5-CSRTT, thereby matching core criteria for a model of ADHD. Because d-amphetamine reduced perseveration in NK1R-/- mice, this action does not require functional NK1R. However, the lack of any improvement of omissions and premature responses in NK1R-/- mice given d-amphetamine suggests that beneficial effects of this psychostimulant in other rodent models, and ADHD patients, need functional NK1R. Finally, our results reveal experimental variables (stimulus parameters, stress and time of day) that could influence translational studies
Classical field theories of first order and lagrangian submanifolds of premultisymplectic manifolds
A description of classical field theories of first order in terms of
Lagrangian submanifolds of premultisymplectic manifolds is presented. For this
purpose, a Tulczyjew's triple associated with a fibration is discussed. The
triple is adapted to the extended Hamiltonian formalism. Using this triple, we
prove that Euler-Lagrange and Hamilton-De Donder-Weyl equations are the local
equations defining Lagrangian submanifolds of a premultisymplectic manifold.Comment: preprint, 27 page
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