Nonlocal Dynamics of Passive Tracer Dispersion with Random Stopping

We investigate the nonlocal behavior of passive tracer dispersion with random stopping at various sites in fluids. This kind of dispersion processes is modeled by an integral partial differential equation, i.e., an advection-diffusion equation with a memory term. We have shown the exponential decay of the passive tracer concentration, under suitable conditions for the velocity field and the probability distribution of random stopping time.Comment: 7 page

A Semantic Model for Federated Queries Over a Normalized Corpus

We present here a model implemented in OWL which improves information retrieval and data integration of the corpus. The model is populated with entities from CALBC and some simple queries over it are presented.
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Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus

GOALS OF INVESTIGATION: The 5-year survival rate for pancreatic ductal adenocarcinoma (PDAC) has remained at <5% for decades because no effective therapies have been identified. Integrin αvβ6 is overexpressed in most PDAC and represents a promising therapeutic target. Thus, we attempted to develop an αvβ6-specific peptide-drug conjugate (PDC) for therapy of PDAC. METHODOLOGY: We conjugated the DNA-binding pyrrolobenzodiazepine (PBD)-based payload SG3249 (tesirine) to an αvβ6-specific 20mer peptide from the VP1 coat protein of foot-and-mouth-disease virus (FMDV) (forming conjugate SG3299) or to a non-targeting peptide (forming conjugate SG3511). PDCs were tested for specificity and toxicity on αvβ6-negative versus-positive PDAC cells, patient-derived cell lines from tumor xenografts, and on two different in vivo models of PDAC. Immunohistochemical analyses were performed to establish therapeutic mechanism. RESULTS: The αvβ6-targeted PDC SG3299 was significantly more toxic (up to 78-fold) for αvβ6-expressing versus αvβ6-negative PDAC cell lines in vitro, and achieved significantly higher toxicity at equal dose than the non-targeted PDC SG3511 (up to 15-fold better). Moreover, SG3299 eliminated established (100mm3) Capan-1 PDAC human xenografts, extending the lifespan of mice significantly (P=0.005). Immunohistochemistry revealed SG3299 induced DNA damage and apoptosis (increased γH2AX and cleaved caspase 3, respectively) associated with significant reductions in proliferation (Ki67), β6 expression and PDAC tumour growth. CONCLUSION: The FMDV-peptide drug conjugate SG3299 showed αvβ6-selectivity in vitro and in vivo and can specifically eliminate αvβ6-positive cancers, providing a promising new molecular- specific therapy for pancreatic cancer

Sleeping Beauty

The story of a princess cast under a magic spell to sleep for 100 years, who can be awakened only by the kiss of a brave prince. To be presented in a fully staged musical version in Cowan Hall for children of all ages.https://digitalcommons.otterbein.edu/production_1979-1980/1003/thumbnail.jp

Influence of echocardiographic and radiographic characteristics on atrial sensing amplitude in patients with Linox Smart S DX defibrillation leads

Background: Single-lead for implantable cardioverter-defibrillator (ICD) with floating atrial sensing dipole is a new diagnostic tool with the potential advantage in terms of arrhythmia discrimination. We sought to determine whether right heart size and dipole position influence atrial sensing. Methods: Atrial sensing (AS) amplitude was measured during implantation (PP, periprocedural), predischarge (IHFU, in-hospital follow-up) and 3–6 months after the procedure (AFU, ambulatory follow-up). Results were related to atrial dipole position in the right atrium (RA) on the basis of chest X-ray examination as well as right heart dimensions at echocardiography. Results: Twenty-four patients were included into final analysis. In 14 (58.3%) patients, sensing dipole was located in regions 1 and 2 of the RA. AS amplitude was greater in regions 1 and 2 when com¬pared to other locations (3.15 vs. 1.2 mV, p = 0.045, 7.53 vs. 3.8 mV, p < 0.001 and 5.63 vs. 2.44 mV, p = 0.017 for PP measurements, IHFU and AFU, respectively). There was a significant negative correlation between AS-PP and short RA dimension (RADs) (r = –0.56, p = 0.02), AS-IHFU and RA area (RAA) (r = –0.45, p < 0.05), AS-AFU and long RA dimension (RADl) (r = –0.46; p = 0.02), AS-AFU and RADs (r = –0,48, p = 0.02), and AS-AFU and RAA (and r = –0.52, p < 0.01). There was no relationship between AS and other right heart dimensions. Conclusions: Larger RA size and low sensing dipole location were associated with lower AS amplitude in single-lead dual chamber ICD

Effectiveness of Medtronic CareLink Express System in identifying patients with high-energy electrotherapy devices requiring clinically significant intervention

   Background: The number of patients with implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy and defibrillator (CRT-D) is growing. This results in high workloads for centers performing standard controls (SC) of these systems. Medtronic CareLink Express® (MCLE) is a solution enabling remote controls (RC) of implantable devices. In cases of detecting arrhythmias or device malfunctioning, it automatically generates alarms transmitted to the controlling physician. The objective of the study was to evaluate the effectiveness of alarms generated by MCLE in identification of patients that require clinically significant intervention during SC. Methods: A total of 119 patients (age 64 ± 14, 17 women) implanted with ICD/CRT-D were included in the trial. Device reprogramming or pharmacological treatment modifications during SC were as­sessed as significant if they were required for optimal clinical management of the patient (effectiveness of antiarrhythmic and resynchronization therapy, also patient safety). Analysis of generated alarms was then performed to assess the effectiveness (sensitivity and specificity) of MCLE in identifying patients that require changes in therapy. Results: Data from 129 transmissions and 129 subsequent SCs were analyzed. 179 alarms were recorded during 96 (74%) transmissions. A total of 333 program changes of implanted devices took place during 107 (83%) SCs. Device reprogramming was considered clinically significant in 27 cases Additionaly, 13 pharmacological treatment modifications were performed. Sensitivity and specificity of alarms generated by MCLE with regards to identification of patients requiring clinically significant intervention was 87% and 31%, respectively. Finally, a statistically significant difference was observed in the number of clinically significant interventions among patients with and without MCLE alarms (33 [86.8%] vs. 5 [13.2%], p = 0.037). Conclusions: Medtronic CareLink Express® is an RC system enabling high-sensitivity supervision of patients with cardia

El objeto de la estética

Fil: Trías, Manuel B.. Universidad Nacional de Cuyo

Peran Digital Marketing pada PT Kreasi Dapur Nusantara

Magang ini bertujuan untuk memahami dan menerapkan strategi pemasaran yang efektif dalam konteks industri F&B yang kompetitif. Laporan ini mencakup analisis dan pengamatan yang dilakukan selama magang di Bidang F&B, dengan berfokus pada berbagai aspek pemasaran, termasuk riset pasar, segmentasi pelanggan, branding, promosi, dan pemasaran digital. Melalui pengalaman ini, penulis memperoleh pemahaman yang mendalam tentang bagaimana pemasaran dapat berperan sebagai alat yang kuat dalam meningkatkan visibilitas merek, daya tarik pelanggan, dan keberhasilan bisnis secara keseluruhan. Selama magang, penulis terlibat dalam berbagai kegiatan pemasaran, seperti mengumpulkan dan menganalisis data pasar untuk memahami preferensi pelanggan, mengembangkan strategi segmentasi yang tepat, serta merancang dan melaksanakan kampanye promosi yang efektif. Penulis juga terlibat dalam pengelolaan platform media sosial perusahaan dan mempelajari praktik terbaik dalam pemasaran digital. Kesimpulan dari pengalaman magang ini adalah bahwa pemasaran memiliki peran penting dalam kesuksesan bisnis F&B. Dalam industri yang kompetitif ini, strategi pemasaran yang tepat dapat memberikan keunggulan kompetitif yang signifikan. Laporan ini diharapkan dapat memberikan wawasan yang bermanfaat tentang pentingnya pemasaran dalam industri F&B, serta memberikan rekomendasi yang relevan untuk meningkatkan strategi pemasaran di Bidang F&B