Quasimodes of a chaotic elastic cavity with increasing local losses

We report non-invasive measurements of the complex field of elastic quasimodes of a silicon wafer with chaotic shape. The amplitude and phase spatial distribution of the flexural modes are directly obtained by Fourier transform of time measurements. We investigate the crossover from real mode to complex-valued quasimode, when absorption is progressively increased on one edge of the wafer. The complexness parameter, which characterizes the degree to which a resonance state is complex-valued, is measured for non-overlapping resonances and is found to be proportional to the non-homogeneous contribution to the line broadening of the resonance. A simple two-level model based on the effective Hamiltonian formalism supports our experimental results

Single-chip CMOS optical microspectrometer

Numerous applications, e.g., systems for chemical analysis by optical absorption and emission line characterization, will benefit from the availability of low-cost single-chip spectrometers. A single-chip CMOS optical microspectrometer containing an array of 16 addressable Fabry–Perot etalons (each one with different resonance cavity length), photodetectors and circuits for read-out, multiplexing and driving a serial bus interface has been fabricated. The result is a chip that can operate using only four external connections (including Vdd and Vss). covering the visible spectral range of the spectrum with FWHM = 18 nm. Frequency output and serial bus interface allow easy multi-sensor, multi-chip interfacing using a microcontroller or a personal computer. Power consumption is 1250 µW for a clock frequency of 1 MHzFundação para a Ciência e a Tecnologia (FCT

Caudal cervical vertebral morphological variation is not associated with clinical signs in Warmblood horses

Background Variation in equine caudal cervical spine morphology at C6 and C7 has high prevalence in Warmblood horses and is suspected to be associated with pain in a large mixed-breed group of horses. At present no data exist on the relationship between radiographic phenotype and clinical presentation in Warmblood horses in a case-control study. Objectives To establish the frequency of radiographically visible morphologic variation in a large group of Warmblood horses with clinical signs and compare this with a group without clinical signs. We hypothesised that occurrence of morphologic variation in the case group would not differ from the control group, indicating there is no association between clinical signs and morphologic variation. Study design Retrospective case-control. Methods Radiographic presence or absence of morphologic variation of cervical vertebrae C6 and C7 was recorded in case (n = 245) and control horses (n = 132). Case and control groups were compared by univariable Pearson's Chi-square and multivariable logistic regression for measurement variables age, sex, breed, degenerative joint disease and morphologic variation at C6 and C7. Odds ratio and confidence intervals were obtained. A P <= 0.05 was considered statistically significant. Results Morphologic variation at C6 and C7 (n = 108/377 = 28.6%; Cases 58/245 = 23.7%; Control 50/132 = 38%) was less frequent in horses with clinical signs in univariable testing (OR 0.48, 95% CI 0.3-0.8, P = 0.001). Age, sex, breed and degenerative joint disease were not retained in the final multivariable logistic regression step whereas morphologic variation remained significantly less present in horses with clinical signs. Main limitations Possible demographic differences between equine clinics. Conclusions Morphologic variation in the caudal cervical spine was detected more frequently in horses without clinical signs. Therefore, radiographic presence of such variation does not necessarily implicate the presence of clinical signs

Evaluating the performance of absolute RSSI positioning algorithm-based microzoning and RFID in construction materials tracking

High accuracy of construction materials tracking with radio frequency identification technology (RFID) is challenging to achieve. The microzoning method consists essentially of an absolute received signal strength indication (RSSI) positioning algorithm on the basis of measuring the distance of tag from antennas base. In this paper, we analyse and examine the effects of microzoning method on the performance of RFID tags. A system was set up whereby RFID tags and antennas with the microzoning method were developed and studied. The performance of the tag antennas was studied with the practical read-range measurements. The study results showed that this absolute algorithm worked reliably and was suitable for RFID applications requiring identification of positions of onsite materials and components. The results also showed that the algorithm achieved a large read range and high accuracy. The study investigates the RFID solutions for Australian LNG (liquefied natural gas) industry and was initiated by the collaboration between Woodside Energy, Curtin University, and Industrial Automation Group Pty Ltd

Model reduction in mathematical pharmacology: integration, reduction and linking of PBPK and systems biology models

In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales. To address the issue of model complexity, we propose the reduction of each type of model separately prior to being linked. We highlight the use of balanced truncation in reducing the linear components of PBPK models, whilst proper lumping is shown to be efficient in reducing typically nonlinear systems biology type models. The overall methodology is demonstrated via two example systems; a model of bacterial chemotactic signalling in Escherichia coli and a model of extracellular regulatory kinase activation mediated via the extracellular growth factor and nerve growth factor receptor pathways. Each system is tested under the simulated administration of three hypothetical compounds; a strong base, a weak base, and an acid, mirroring the parameterisation of pindolol, midazolam, and thiopental, respectively. Our method can produce up to an 80% decrease in simulation time, allowing substantial speed-up for computationally intensive applications including parameter fitting or agent based modelling. The approach provides a straightforward means to construct simplified Quantitative Systems Pharmacology models that still provide significant insight into the mechanisms of drug action. Such a framework can potentially bridge pre-clinical and clinical modelling - providing an intermediate level of model granularity between classical, empirical approaches and mechanistic systems describing the molecular scale

Super Stability of Laminar Vortex Flow in Superfluid 3He-B

Vortex flow remains laminar up to large Reynolds numbers (Re~1000) in a cylinder filled with 3He-B. This is inferred from NMR measurements and numerical vortex filament calculations where we study the spin up and spin down responses of the superfluid component, after a sudden change in rotation velocity. In normal fluids and in superfluid 4He these responses are turbulent. In 3He-B the vortex core radius is much larger which reduces both surface pinning and vortex reconnections, the phenomena, which enhance vortex bending and the creation of turbulent tangles. Thus the origin for the greater stability of vortex flow in 3He-B is a quantum phenomenon. Only large flow perturbations are found to make the responses turbulent, such as the walls of a cubic container or the presence of invasive measuring probes inside the container.Comment: 4 pages, 6 figure

Performance of a GridPix detector based on the Timepix3 chip

A GridPix readout for a TPC based on the Timepix3 chip is developed for future applications at a linear collider. The GridPix detector consists of a gaseous drift volume read out by a single Timepix3 chip with an integrated amplification grid. Its performance is studied in a test beam with 2.5 GeV electrons. The GridPix detector detects single ionization electrons with high efficiency. The Timepix3 chip allowed for high sample rates and time walk corrections. Diffusion is found to be the dominating error on the track position measurement both in the pixel plane and in the drift direction, and systematic distortions in the pixel plane are below 10 $\mu$m. Using a truncated sum, an energy loss (dE/dx) resolution of 4.1% is found for an effective track length of 1 m.Comment: To be published in Nuclear Instruments and Methods in Physics Research Section

GRAIL, an omni-directional gravitational wave detector

A cryogenic spherical and omni-directional resonant-mass detector proposed by the GRAIL collaboration is described.Comment: 5 pages, 4 figs., contribution to proceedings GW Data Analysis Workshop, Paris, nov. 199

Optical microspectrometer using a micro-instrumentation platform

MEMS are usually designed for measuring one parameter and on-chip co-integration of sensor (microstructure) and readout circuits is often pursued. In a multi-parameter measurement system, yield considerations and fabrication compatibility problems favor micro-instruments based on active Si-MCM techniques. The generic device is based on a stacked structure with a universally applicable active silicon MCM platform that contains all the infrastructural functions of a measurement system. Customizing the microsystem requires flip-chip attach of sensor dies and a commercially available microcontroller die, which is subsequently programmed for the intended application. The micro-instrument features a data pre processing capability to provide high-level data (e.g. spectral information rather than raw sensor data) and to communicate with a host processor intelligently.STW - project DEL 55.3733.TU Delft, Fundação para a Ciência e Tecnologia (FCT) - Program Praxis XXI-BD/5181/95

A single-chip CMOS optical microspectrometer with light-to-frequency converter and bus interface

A single-chip CMOS optical microspectrometer containing an array of 16 addressable Fabry–Perot etalons (each one with a different resonance cavity length), photodetectors, and circuits for readout, multiplexing, and driving a serial bus interface has been fabricated in a standard 1.6 um CMOS technology (chiparea 3.9x4.2 mm2). The result is a chip that can operate using only four external connections (including and ) covering the optical range of 380–500 nm with full-width half-maximum (FWHM) = 18 nm. Frequency output and serial bus interface allow easy multisensor and multichip interfacing using a microcontroller or a personal computer. Power consumption is 1250 W for a clock frequency of 1 MHz.Fundação para a Ciência e a Tecnologia (FCT