153 research outputs found
Adsorpce fosforečnanů z vody recyklovaným betonem
It was only very recently that recycled concrete has also started to be used in water management primarily as a sorbent or reagent. Important factors influencing its use include mainly its origin, chemical, physical and mechanical characteristics. Adsorption kinetics was measured experimentally (Freundlich and Langmuir isotherm); and efficiency, values of adsorption capacity and changes of water chemical reactions due to added recycled concrete were found. Phosphates were removed either from standard solutions or from surface water.Recyklovaný beton se díky svým vlastnostem začal v posledních letech uplatňovat i ve vodním hospodářství především jako sorbent nebo reakční činidlo. K důležitým faktorům, ovlivňujícím jeho použití patří zejména jeho původ, chemické, fyzikální a mechanické charakteristiky. Experimentálně byla zjišťována kinetika adsorpce (Freundlichova a Langmuirova izoterma), účinnost, hodnoty adsorpční kapacity a změny chemické reakce vody vlivem přidaného recyklovaného betonu. Fosforečnany byly odstraňovány jak ze standardních roztoků, tak z povrchové vody
Two-Sample Tests that are Safe under Optional Stopping, with an Application to Contingency Tables
We develop E variables for testing whether two data streams come from the
same source or not, and more generally, whether the difference between the
sources is larger than some minimal effect size. These E variables lead to
tests that remain safe, i.e. keep their Type-I error guarantees, under flexible
sampling scenarios such as optional stopping and continuation. In special cases
our E variables also have an optimal `growth' property under the alternative.
We illustrate the generic construction through the special case of 2x2
contingency tables, where we also allow for the incorporation of different
restrictions on a composite alternative. Comparison to p-value analysis in
simulations and a real-world example show that E variables, through their
flexibility, often allow for early stopping of data collection, thereby
retaining similar power as classical methods
Generic E-Variables for Exact Sequential k-Sample Tests that allow for Optional Stopping
We develop E-variables for testing whether two or more data streams come from the same source or not, and more generally, whether the difference between the sources is larger than some minimal effect size. These E-variables lead to exact, nonasymptotic tests that remain safe, i.e. keep their type-I error guarantees, under flexible sampling scenarios such as optional stopping and continuation. In special cases our E-variables also have an optimal 'growth' property under the alternative. While the construction is generic, we illustrate it through the special case of k x 2 contingency tables, where we also allow for the incorporation of different restrictions on a composite alternative. Comparison to p-value analysis in simulations and a real-world example show that E-variables, through their flexibility, often allow for early stopping of data collection, thereby retaining similar power as classical methods, while also retaining the option of extending or combining data afterwards
Two-sample tests that are safe under optional stopping
We develop E variables for testing whether two data streams come from the same source or not, and more generally, whether the difference between the sources is larger than some minimal effect size. These E variables lead to tests that remain safe, i.e. keep their Type-I error guarantees, under flexible sampling scenarios such as optional stopping and continuation. In special cases our E variables also have an optimal `growth' property under the alternative. We illustrate the generic construction through the special case of 2x2 contingency tables, where we also allow for the incorporation of different restrictions on a composite alternative. Comparison to p-value analysis in simulations and a real-world example show that E variables, through their flexibility, often allow for early stopping of data collection, thereby retaining similar power as classical methods
Micrometeorological, plant-ecological, and soil-hydrological measurements in stands of spruce and beech in the Tharandt forest
This paper addresses micrometeorological, plant-ecological, and soil-hydrological measurements in stands of spruce and beech as a means to understand the processes. The long-term flux site Anchor Station Tharandt (dominated by 120-year-old spruce) shows the high dynamics of land surface- atmosphere interactions as well as the climatologically relevant effects on turbulent energy flux partitioning, carbon sequestration, and evapotranspiration (ET). Climate, phenology, and fluxes support the idea of dividing the year into an ‘active phase’ (April–September) and a ‘dormant phase’ (October–March); carbon sequestration, available energy (net radiation), and sensible heat flux are almost negligible in the dormant season. Only ET shows a significant contribution to the annual budget (25 % of the active phase) from interception (evaporation from wetted needles) driven by sensible heat flux from the atmosphere. The interannual variation of the fluxes is generally small (e. g., 500 to 650 gC m-2 yr-1 of C uptake) even for the severe drought year of 2003 (400 gC m-2) or with thinning in 2002. Compared to the beech site, the spruce site – at least in the active season – experienced similar rates of ET but smaller rates of C uptake. Canopy drip was 55 % of precipitation at the spruce site. Canopy drip (40 %) and stem flow (25 %) added up to 65 % of canopy precipitation at the beech site. This difference likely explains the generally higher soil moisture at the beech site. As a consequence of this study, models with sufficient complexity are recommended to represent the structural differences of different forest types including their phenophases. For a better representation of forests, e. g., in climate models, land surface–atmosphere interactions must be included.Diese Arbeit benutzt mikrometeorologische, pflanzenökologische und bodenhydrologische Messungen als Mittel zum Prozessverständnis. Der langfristige Flussmessstandort Ankerstation Tharandter Wald (von 120 jährigen Fichten dominiert) zeigt die große Dynamik der Landoberflächen-Atmosphären-Wechselwirkungen wie auch ihre Klimaeffekte auf die Verteilung der turbulenten Wärmeströme, die Kohlenstoffsequestrierung und die Evapotranspiration (ET). Klimawerte, Phänologie und Flüsse unterstützen die Einteilung des Jahres in eine ‚aktive Phase’ (April–September) und eine ‚Ruhephase’ (Oktober– März): Kohlenstoffsequestrierung, zur Verfügung stehende Energie (Strahlungsbilanz) und fühlbarer Wärmestrom sind in der Ruhephase praktisch vernachlässigbar. Nur ET zeigt einen signifikanten Beitrag zur Jahresbilanz (25 % der aktiven Phase) aus der Interzeption (Evaporation von benetzten Nadeln), die vom fühlbaren Wärmestrom aus der Atmosphäre angetrieben wird. Die zwischenjährliche Variation der Flüsse ist im Allgemeinen klein (z. B. 500–650 gC m-2 yr -1) C-Aufnahme), selbst mit dem starken Dürrejahr 2003 (400 gC m-2) oder dem Effekt der Durchforstung 2002. Verglichen mit der Buche erreicht die Fichte – zumindest in der aktiven Periode – ähnliche Werte von ET aber niedrigere bei der C-Aufnahme. Die Kronentraufe beträgt bei der Fichte nur ca. 55 % des Niederschlages, bei der Buche summieren sich ca. 40 % Kronentraufe und knapp 25 % Stammabfluss zu etwa 65 % Bestandesniederschlag. Dieser Unterschied erklärt möglicherweise die im Allgemeinen höhere Bodenfeuchte am Buchenstandort. Als Resultat aus dieser Arbeit werden Modelle mit ausreichender Komplexität empfohlen, welche Bestandesstruktur und Phänophasen berücksichtigen. Das ist eine Voraussetzung für eine bessere Berücksichtigung von Wäldern mit ihren Landoberflächen-
Atmosphären-Wechselwirkungen, z. B. in Klimamodellen
The Safe Logrank Test: Error Control under Continuous Monitoring with Unlimited Horizon
We introduce the safe logrank test, a version of the logrank test that provides type-I error guarantees under optional stopping and optional continuation. The test is sequential without the need to specify a maximum sample size or stopping rule and allows for cumulative meta-analysis with Type-I error control. The method can be extended to define anytime-valid confidence intervals. All these properties are a virtue of the recently developed martingale tests based on E-variables, of which the safe logrank te
ТЕХНОГЕННІ РОДОВИЩА ТА ЇХ КЛАСИФІКАЦІЯ
На багатьох гірничодобувних підприємствах тих, що забезпечують мінера-льною сировиною чорну і кольорову металургію України та країн СНД, виник-ла проблема з розвіданими запасами. Резерв запасів багатьох видів корисних копалини на експлуатованих родовищах недостатній для забезпечення повної проектної потужності. Стан сировинних баз багатьох найважливіших гірничо-добувних регіонів і підприємств, що діють, різко погіршав у зв'язку з висна-женням запасів, зниженням їх якісних і економічних характеристик ускладнен-ням умов відробітку в результаті тривалої і інтенсивної експлуатації раніше освоєних родовищ. Основною причиною ситуації, що створилася, можна назва-ти зниження фінансування геологорозвідувальних робіт для освоєння нових ро-довищ необхідної мінеральної сировини
Codesigning a systemic discharge intervention for inpatient mental health settings (MINDS): a protocol for integrating realist evaluation and an engineering-based systems approach
© 2023 The Author(s). Published by BMJ. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Introduction: Transition following discharge from mental health hospital is high risk in terms of relapse, readmission and suicide. Discharge planning supports transition and reduces risk. It is a complex activity involving interacting systemic elements. The codesigning a systemic discharge intervention for inpatient mental health settings (MINDS) study aims to improve the process for people being discharged, their carers/supporters and staff who work in mental health services, by understanding, co-designing and evaluating implementation of a systemic approach to discharge planning. Methods and analysis: The MINDS study integrates realist research and an engineering-informed systems approach across three stages. Stage 1 applies realist review and evaluation using a systems approach to develop programme theories of discharge planning. Stage 2 uses an Engineering Better Care framework to codesign a novel systemic discharge intervention, which will be subjected to process and economic evaluation in stage 3. The programme theories and resulting care planning approach will be refined throughout the study ready for a future clinical trial. MINDS is co-led by an expert by experience, with researchers with lived experience co-leading each stage. Ethics and dissemination: MINDS stage 1 has received ethical approval from Yorkshire & The Humber—Bradford Leeds (Research Ethics Committee (22/YH/0122). Findings from MINDS will be disseminated via high-impact journal publications and conference presentations, including those with service user and mental health professional audiences. We will establish routes to engage with public and service user communities and National Health Service professionals including blogs, podcasts and short videos. Trial registration number: MINDS is funded by the National Institute of Health Research (NIHR 133013) https://fundingawards.nihr.ac.uk/award/NIHR133013. The realist review protocol is registered on PROSPERO. PROSPERO registration number: CRD42021293255.Peer reviewe
Direct structural analysis of modified RNA by fluorescent in-line probing
Chemical probing is a common method for the structural characterization of RNA. Typically, RNA is radioactively end-labelled, subjected to probing conditions, and the cleavage fragment pattern is analysed by gel electrophoresis. In recent years, many chemical modifications, like fluorophores, were introduced into RNA, but methods are lacking that detect the influence of the modification on the RNA structure with single-nucleotide resolution. Here, we first demonstrate that a 5′-terminal 32P label can be replaced by a dye label for in-line probing of riboswitch RNAs. Next, we show that small, highly structured FRET-labelled Diels–Alderase ribozymes can be directly probed, using the internal or terminal FRET dyes as reporters. The probing patterns indeed reveal whether or not the attachment of the dyes influences the structure. The existence of two dye labels in typical FRET constructs is found to be beneficial, as ‘duplexing’ allows observation of the complete RNA on a single gel. Structural information can be derived from the probing gels by deconvolution of the superimposed band patterns. Finally, we use fluorescent in-line probing to experimentally validate the structural consequences of photocaging, unambiguously demonstrating the intentional destruction of selected elements of secondary or tertiary structure
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