297 research outputs found
Computergestützte Leitstruktursuchen in Moleküldatenbanken am Beispiel der humanen Carboanhydrase II
Exact thermodynamic Casimir forces for an interacting three-dimensional model system in film geometry with free surfaces
The limit n to infinity of the classical O(n) phi^4 model on a 3d film with
free surfaces is studied. Its exact solution involves a self-consistent 1d
Schr\"odinger equation, which is solved numerically for a partially discretized
as well as for a fully discrete lattice model. Numerically exact results are
obtained for the scaled Casimir force at all temperatures. Obtained via a
single framework, they exhibit all relevant qualitative features of the
thermodynamic Casimir force known from wetting experiments on Helium-4 and
Monte Carlo simulations, including a pronounced minimum below the bulk critical
point.Comment: 5 pages, 2 figure
The role of antibiotics in the treatment of chronic prostatitis: A consensus statement
Practical guidelines for the diagnosis and treatment of chronic prostatitis are presented. Chronic prostatitis is classified as chronic bacterial prostatitis (culture-positive) and chronic inflammatory prostatitis (culture-negative). If chronic bacterial prostatitis is suspected, based on relevant symptoms or recurrent UTIs, underlying urological conditions should be excluded by the following tests: rectal examination, midstream urine culture and residual urine. The diagnosis should be confirmed by the Meares and Stamey technique. Antibiotic therapy is recommended for acute exacerbations of chronic prostatitis, chronic bacterial prostatitis and chronic inflammatory prostatitis, if there is clinical, bacteriological or supporting immunological evidence of prostate infection. Unless a patient presents with fever, antibiotic treatment should not be initiated immediately except in cases of acute prostatitis or acute episodes in a patient with chronic bacterial prostatitis. The work-up, with the appropriate investigations should be done first, within a reasonable time period which, preferably, should not be longer than 1 week. During this period, nonspecific treatment, such as appropriate analgesia to relieve symptoms, should be given. The minimum duration of antibiotic treatment should be 2-4 weeks. If there is no improvement in symptoms, treatment should be stopped and reconsidered. However, if there is improvement, it should be continued for at least a further 2-4 weeks to achieve clinical cure and, hopefully, eradication of the causative pathogen. Antibiotic treatment should not be given for 6-8 weeks without an appraisal of its effectiveness. Currently used antibiotics are reviewed. Of these, the fluoroquinolones ofloxacin and ciprofloxacin are recommended because of their favourable antibacterial spectrum and pharmacokinetic profile. A number of clinical trials are recommended and a standard study design is proposed to help resolve some outstanding issues
Thermodynamic Casimir effects involving interacting field theories with zero modes
Systems with an O(n) symmetrical Hamiltonian are considered in a
-dimensional slab geometry of macroscopic lateral extension and finite
thickness that undergo a continuous bulk phase transition in the limit
. The effective forces induced by thermal fluctuations at and above
the bulk critical temperature (thermodynamic Casimir effect) are
investigated below the upper critical dimension by means of
field-theoretic renormalization group methods for the case of periodic and
special-special boundary conditions, where the latter correspond to the
critical enhancement of the surface interactions on both boundary planes. As
shown previously [\textit{Europhys. Lett.} \textbf{75}, 241 (2006)], the zero
modes that are present in Landau theory at make conventional
RG-improved perturbation theory in dimensions ill-defined. The
revised expansion introduced there is utilized to compute the scaling functions
of the excess free energy and the Casimir force for temperatures
T\geqT_{c,\infty} as functions of , where
is the bulk correlation length. Scaling functions of the
-dependent residual free energy per area are obtained whose
limits are in conformity with previous results for the Casimir amplitudes
to and display a more reasonable
small- behavior inasmuch as they approach the critical value
monotonically as .Comment: 23 pages, 10 figure
Excess free energy and Casimir forces in systems with long-range interactions of van-der-Waals type: General considerations and exact spherical-model results
We consider systems confined to a -dimensional slab of macroscopic lateral
extension and finite thickness that undergo a continuous bulk phase
transition in the limit and are describable by an O(n) symmetrical
Hamiltonian. Periodic boundary conditions are applied across the slab. We study
the effects of long-range pair interactions whose potential decays as as , with and , on
the Casimir effect at and near the bulk critical temperature ,
for . For the scaled reduced Casimir force per unit cross-sectional
area, we obtain the form L^{d} {\mathcal F}_C/k_BT \approx \Xi_0(L/\xi_\infty)
+ g_\omega L^{-\omega}\Xi\omega(L/\xi_\infty) + g_\sigma L^{-\omega_\sigm a}
\Xi_\sigma(L \xi_\infty). The contribution decays for
algebraically in rather than exponentially, and hence
becomes dominant in an appropriate regime of temperatures and . We derive
exact results for spherical and Gaussian models which confirm these findings.
In the case , which includes that of nonretarded van-der-Waals
interactions in dimensions, the power laws of the corrections to scaling
of the spherical model are found to get modified by logarithms.
Using general RG ideas, we show that these logarithmic singularities originate
from the degeneracy that occurs for the spherical
model when , in conjunction with the dependence of .Comment: 28 RevTeX pages, 12 eps figures, submitted to PR
Casimir force in O(n) lattice models with a diffuse interface
On the example of the spherical model we study, as a function of the
temperature , the behavior of the Casimir force in O(n) systems with a
diffuse interface and slab geometry , where is
the dimensionality of the system. We consider a system with nearest-neighbor
anisotropic interaction constants parallel to the film and
across it. The model represents the limit of O(n) models
with antiperiodic boundary conditions applied across the finite dimension
of the film. We observe that the Casimir amplitude of the anisotropic -dimensional system is
related to that one of the isotropic system via
. For we find the exact Casimir amplitude , as well as the exact scaling functions of
the Casimir force and of the helicity modulus . We obtain that
, where is the critical temperature of the
bulk system. We find that the effect of the helicity is thus strong that the
Casimir force is repulsive in the whole temperature region.Comment: 15 pages, 3 figure
The bulk correlation length and the range of thermodynamic Casimir forces at Bose-Einstein condensation
The relation between the bulk correlation length and the decay length of
thermodynamic Casimir forces is investigated microscopically in two
three-dimensional systems undergoing Bose-Einstein condensation: the perfect
Bose gas and the imperfect mean-field Bose gas. For each of these systems, both
lengths diverge upon approaching the corresponding condensation point from the
one-phase side, and are proportional to each other. We determine the
proportionality factors and discuss their dependence on the boundary
conditions. The values of the corresponding critical exponents for the decay
length and the correlation length are the same, equal to 1/2 for the perfect
gas, and 1 for the imperfect gas
Finite-size effects in the spherical model of finite thickness
A detailed analysis of the finite-size effects on the bulk critical behaviour
of the -dimensional mean spherical model confined to a film geometry with
finite thickness is reported. Along the finite direction different kinds of
boundary conditions are applied: periodic , antiperiodic and free
surfaces with Dirichlet , Neumann and a combination of Neumann and
Dirichlet on both surfaces. A systematic method for the evaluation of
the finite-size corrections to the free energy for the different types of
boundary conditions is proposed. The free energy density and the equation for
the spherical field are computed for arbitrary . It is found, for ,
that the singular part of the free energy has the required finite-size scaling
form at the bulk critical temperature only for and . For the
remaining boundary conditions the standard finite-size scaling hypothesis is
not valid. At , the critical amplitude of the singular part of the free
energy (related to the so called Casimir amplitude) is estimated. We obtain
, and
, implying a fluctuation--induced attraction between
the surfaces for and repulsion in the other two cases. For and
we find a logarithmic dependence on .Comment: Version published in J. Phys. A: Math. Theo
The translation, validity and reliability of the German version of the Fremantle Back Awareness Questionnaire
Background: The Fremantle Back Awareness Questionnaire (FreBAQ) claims to assess disrupted self-perception of the back. The aim of this study was to develop a German version of the Fre-BAQ (FreBAQ-G) and assess its test-retest reliability, its known-groups validity and its convergent validity with another purported measure of back perception.
Methods: The FreBaQ-G was translated following international guidelines for the transcultural adaptation of questionnaires. Thirty-five patients with non-specific CLBP and 48 healthy participants were recruited. Assessor one administered the FreBAQ-G to each patient with CLBP on two separate days to quantify intra-observer reliability. Assessor two administered the FreBaQ-G to each patient on day 1. The scores were compared to those obtained by assessor one on day 1 to assess inter-observer reliability. Known-groups validity was quantified by comparing the FreBAQ-G score between patients and healthy controls. To assess convergent validity, patient\u27s FreBAQ-G scores were correlated to their two-point discrimination (TPD) scores.
Results: Intra- and Inter-observer reliability were both moderate with ICC3.1 = 0.88 (95%CI: 0.77 to 0.94) and 0.89 (95%CI: 0.79 to 0.94), respectively. Intra- and inter-observer limits of agreement (LoA) were 6.2 (95%CI: 5.0±8.1) and 6.0 (4.8±7.8), respectively. The adjusted mean difference between patients and controls was 5.4 (95%CI: 3.0 to 7.8, p\u3c0.01). Patient\u27s FreBAQ-G scores were not associated with TPD thresholds (Pearson\u27s r = -0.05, p = 0.79).
Conclusions: The FreBAQ-G demonstrated a degree of reliability and known-groups validity. Interpretation of patient level data should be performed with caution because the LoA were substantial. It did not demonstrate convergent validity against TPD. Floor effects of some items of the FreBAQ-G may have influenced the validity and reliability results. The clinimetric properties of the FreBAQ-G require further investigation as a simple measure of disrupted self-perception of the back before firm recommendations on its use can be made
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