Interactive spatial multimedia for communication of art in the physical museum space

ABSTRACT This paper discusses the application of three spatial multimedia techniques for communication of art in the physical museum space. In contrast to the widespread use of computers in cultural heritage and natural science museums, it is generally a challenge to introduce technology in art museums without disturbing the art works. This has usually been limited to individual audio guides. In our case we strive to achieve holistic and social experiences with seamless transitions between art experience and communication related to the artworks. To reach a holistic experience with minimal disturbance of the artworks we apply three spatial multimedia techniques where the only interaction device needed is the human body. The three techniques are: 1) spatially bounded audio; 2) floor-based multimedia; 3) multimedia interior. The paper describes the application of these techniques for communication of information in a Mariko Mori exhibition. The multimedia installations and their implementation are described. It is argued that the utilization of the spatial multimedia techniques support holistic and social art experience. The multimedia installations were in function for a three and a half month exhibition period and they were approved on beforehand by the artist to be in concordance with the artworks

Practical evaluation of polycrystalline photovoltaic module efficiency under Karaganda conditions

Nowadays, seven major projects aiming at solar power plants development with total capacity of 300 MW have been introducedin Kazakhstan, which advances the use of non-conventional renewable energy sources and develops the technologies to promotethe solar energy. The paper reports on the research focused on the design and construction of 60 MW solar power plant in the cityof Saran. An experimental solar power plant has been built at Karaganda State Technical University to study technical parametersof photovoltaic modules under operational conditions and their adjustment to climatic conditions of Karaganda located in CentralKazakhstan. The statistical analysis of data was performed, and the distribution parameters with the criteria for processing experi-mental results were evaluated. It was found out that the monitoring system and the change in the values of Azimuth and Zenithangles of solar modules will be effective for Karaganda. The results of observations have shown that the amount of electrical ener-gy produced in 2014 exceeded the amount generated in 2015 in the range of 10 %, depending on the month of the year. A temper-ature increase by 1 °C from 25 °C reduces the solar panel capacity by approximately 0.51 %

MicroRNA Profiling in Ocular Adnexal Lymphoma: A Role for MYC and NFKB1 Mediated Dysregulation of MicroRNA Expression in Aggressive Disease

Citation: Hother C, Rasmussen PK, Joshi T, et al. MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease. Invest Ophthalmol Vis Sci. 2013;54:5169-5174. DOI: 10.1167/iovs.13-12272 PURPOSE. Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease. METHODS. Using LNA-based arrays from Exiqon, we performed global microRNA (miRNA) expression profiling of 18 EMZLs and 25 DLBCLs involving ocular adnexal sites to investigate changes in the miRNA expression in low-versus high-grade disease. Findings were confirmed by real-time quantitative PCR (RTq-PCR). RESULTS. Our analysis revealed 43 miRNAs with altered expression profiles in DLBCL compared to EMZL. Seven of the miRNAs down-regulated in DLBCL relative to EMZL showed enrichment for a direct transcriptional repression by the oncoprotein MYC. We also report a possible loss-of-regulation of NFKB1 and its downstream miRNAs. In addition, our analysis identified a group of DLBCLs whose expression profiles resembled that of EMZL. Although transformation of EMZL to DLBCL in the ocular adnexal region is rare, we hypothesize that the intermediate group potentially may derive from transformation of EMZL that was not recognized by histology. CONCLUSIONS. We conclude that fundamental differences in miRNA expression exist between ocular adnexal EMZL and DLBCL, mainly due to differences in MYC and NF-+B regulatory pathways

Improved prediction of mortality by combinations of inflammatory markers and standard clinical scores in patients with acute-on-chronic liver failure and acute decompensation

BACKGROUND AND AIM: Acute-on-chronic liver failure (ACLF) as a sinister prognosis and there is a need for accurate biomarkers and scoring systems to better characterize ACLF patients and predict prognosis. Systemic inflammation and renal failure are hallmarks in ACLF disease development and progression. We hypothesized that the combination of specific inflammatory markers in combination with clinical scores are better predictors of survival than the originally developed CLIF-C acute decompensation (AD) and CLIF-C ACLF scores. METHODS: We re-evaluated all previously measured inflammatory markers in 522 patients from the CANONIC study, 342 without and 180 with ACLF. We used the Harrell's C-index to determine the best marker alone or in combination with the original scores and calculated new scores for prediction of mortality in the original CANONIC cohort. RESULTS: The best markers to predict 90-day mortality in patients without ACLF were the plasma macrophage activation markers soluble (s)CD163 and mannose receptor (sMR). Urinary neutrophil gelatinase associated lipocalin (UNGAL) and sCD163 were predictors for 28-day mortality in patients with ACLF. The new developed CLIF-C AD+sMR score in patients without ACLF improved 90-days mortality prediction compared to the original CLIF-C AD score (C-index 0.82(0.78-0.86) vs. 0.74(0.70-0.78, P=0.004). Further, the new CLIF-C ACLF+sCD163+UNGAL improved the original CLIF-C ACLF score for 28-days mortality (0.85(0.79-0.91) vs. 0.75(0.70-0.80), P=0.039). CONCLUSIONS: The capability of these inflammatory markers to improve the original prognostic scores in cirrhosis patients without and with ACLF points to a key role of macrophage activation and inflammation in the development and progression of AD and ACLF