The first synthesis of 2-amino-1,4-dihydroquinolines

A versatile strategy is described for the synthesis of new 2-amino-1,4-dihydroquinolines. It involved a Knoevenagel condensation of N-protected-2-amino-5-bromobenzaldehyde with ethylcyanoacetate, followed by a cyclization and protection of the NH group to afford the key intermediates 7 or 19. Then various 1,4 addition reactions have been performed to introduce substituents on the upper part of the 2-amino-1,4-dihydroquinolines

Synthesis and biological studies of new quinazolines with ether functions in position 2

International audienc

A new strategy for the synthesis of optically active benzylic fluorides and corresponding five-membered heteroaromatic analogues.

International audienc

Synthesis of Propargylic Fluorides toward Carbo- and Heterocycles with Mono- and gem-Difluorinated Side Chains

International audienceThis review reports the synthesis of propargylic derivatives with alkyl chains bearing either one fluorine or a gem-difluoro system. The preparation of the different categories of fluorinated derivatives is analyzed in a systematic manner, based on the nature of substituents close to the fluorine atom(s). In the second part of this review are summarized the synthetic applications of these fluorinated propargylic intermediates, focusing mainly on the preparation of carbo- and heterocyclic derivatives. 1 Introduction 2 Synthesis of Propargylic Fluorides 3 Use of Propargylic Fluorides in the Preparation of Carbo- and Heterocycles with Fluorine-Containing Side Chains 4 Conclusions and Perspectives © Georg Thieme VerlagStuttgart · New York

New enantioselective synthesis of monofluorinated pyridines designed for the preparation of chemical libraries.

International audienc

A rapid access to new fluorinated dienes and benzylic fluorides via metathesis on propargylic fluorides.

International audienc

Microwave Spectrum of 1-Cyano-3-fluoro-but-1-ene.

International audienceThe rotational spectrum of the 1-cyano-3-fluoro-but-1-ene has been recorded with a pulsed-nozzle microwave Fourier transform spectrometer over the range 6-20 GHz. The frequencies were fitted to the Hamiltonian of Watson (A-reduction, I(r) representation). The resulting rotational constants are A = 7493.404(1) MHz, B = 1211.9831(2) MHz, and C = 1096.0908(1) MHz. By comparing the experimental rotational constants with those obtained by ab initio calculations, we found without ambiguity that the stable conformation for the molecule is the one with the fluorine atom lying in the C&bond;CCN plane (CF-eclipsed conformer). Copyright 2000 Academic Press

Enantioselective Synthesis of methyl-5-(R)-fluorohep-6-ynoate

International audienc

Synthesis of new selected analogues of the proapoptotic and anticancer molecule HA 14-1.

International audienc