Adjuvant radiotherapy in the management of porocarcinoma with lymphatic micrometastasis

Background. Porocarcinoma is a rare skin tumor originating from dermal sweat glands. Surgical procedures are the first choice of treatment, but the role of adjuvant therapies, such as chemotherapy and radiotherapy (RT), is not clear. In this case report and review of the literature, we aimed to present a patient who underwent adjuvant RT for the diagnosis of porocarcinoma with lymphatic micrometastasis and a review of the current literature.  Case summary. A 61-year-old male was admitted to the dermatology department for a nodular lesion on the left knee skin. An excisional biopsy was performed, and the pathology result was reported as porocarcinoma. The closest surgical margin of the tumor was 0.2 cm. In the inguinal sentinel lymph node sampling, two of the three removed lymph nodes had micrometastases. Then, adjuvant RT was applied to the left inguinofemoral lymphatics and primary tumor bed. No recurrence was observed in the patient with a follow-up period of 24 months. No acute or late toxicity was observed including lymphedema, subcutaneous fibrosis, or stiffness of the knee joint. Conclusions. Although adjuvant RT is not a routinely recommended treatment, it can be applied to increase local and regional control in patients with high-risk factors for recurrence or with lymph node metastases. There is a great need for clinical studies clarifying the role of RT, but for now, all patients should undergo multidisciplinary evaluation when a decision on adjuvant therapies is made

Effect of different curing conditions on flexural and compressive strength of fly ash mortars

WOS: 000443165200001In this study the effect of accelerated curing on the early flexural and compressive strengths of fly ash mortars were investigated. In the mortar mixtures CEM I 42.5 R type cement and C class C fly ash with different proportions were used. 40/40/160 mm prismatic specimens were prepared from these mortars. The mortar samples cured at 7 different curing conditions. Curing conditions are standard curing, 35 degrees C and 85 degrees C hot water curing. These curing conditions applied on specimens for different times. Flexural and compressive strengths were performed on the mortar specimens. Obtained test results were comparatively evaluated. The results of this study revealed that, early age strength gain under standard curing conditions due to fly ash inclusion can be compensated by accelerated curing

Effect of aspect ratio and volume fraction of steel fiber on the mechanical properties of SFRC

WOS: 000245498000013In this study, effects of aspect ratio (l/d) and volume fraction (V-f) of steel fiber on the compressive strength, split tensile strength, flexural strength and ultrasonic pulse velocity of steel fiber reinforced concrete (SFRC) were investigated. For this purpose, hooked-end bundled steel fibers with three different l/d ratios of 45, 65 and 80 were used. Three different fiber volumes were added to concrete mixes at 0.5%, 1.0% and 1.5% by volume of concrete. Ten different concrete mixes were prepared. After 28 days of curing, compressive, split and flexural strength as well as ultrasonic pulse velocity were determined. It was found that, inclusion of steel fibers significantly affect the split tensile and flexural strength of concrete accordance with l/d ratio and V-f. Besides, mathematical expressions were developed to estimate the compressive, flexural and split tensile strength of SFRCs regarding l/d ratio and V-f of steel fibers. (c) 2006 Elsevier Ltd. All rights reserved

The effect of high temperature on the compressive strength of mortars

WOS: 000309493700014In this study, the effect of elevated temperature on the compressive strength of mortars containing fly ash, silica fume and pumice was investigated. Thirteen mortar mixtures were produced by replacing 0%, 5%, 10%, 15% and 20% of cement with a fly ash, silica fume and pumice. Totally, 3900 cube (50 x 50 x 50 mm) mortar specimens were prepared from these mortar mixtures and cured at 7, 28 and 90 days. After standard curing period. specimens were dried in a room temperature for 7 days and then exposed to temperature of 20, 150, 300, 450, 600 and 750 degrees C for 1 h in ceramic furnace. Afterwards, the compressive strengths of the specimens were determined. It was concluded that, compressive strengths of mortars containing pozzolan were less affected high temperature than that of control mortars. (C) 2012 Elsevier Ltd. All rights reserved

Abscopal Effect, From Myth to Reality

The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the regression of non-irradiated metastatic lesions at a distance from the primary site of irradiation. This review will focus on understanding the biological rationale behind the abscopal effect of radiotherapy (RT), which has a recently renewed interest as a result of the successes achieved with immunotherapy and RT in combination. Both RT and immunotherapy are standard components of modern treatment regimens. Combination of these two modalities results in an increased response in the irradiated lesions themselves and the metastatic regions distant from the site of irradiation. We will summarize the abscopal effect of radiotherapy, in particular, the synergistic effect of RT and immunotherapy.PubMedWo

Undifferentiated nasopharyngeal carcinoma with isolated central nervous system metastasis

Central nervous system (CNS) metastasis from nasopharyngeal carcinoma is an extremely rare event. Here, we report a case of nasopharyngeal carcinoma with isolated CNS metastases 45 months after the successful treatment of primary tumor