Performance evaluation of dynamically flattened gain L-band RAMAN-EDFA-RAMAN hybrid optical amplifier for super dense wavelength division multiplexing system

In this paper, we have evaluated the performances of super dense Wavelength Division Multiplexing (SD-WDM) system with respect to flat gain. RAMAN-EDFA-RAMAN hybrid optical amplifier (HOA) is the backbone of the system. Further, this model has investigated the effects in terms of L-band flattened gain, output power, crosstalk, and bit error rate with 50 GHz channel spacing. Flat gain greater than 14 dB has obtained at 5 mW and reported the poor performances by 7 mW and 17 mW with the range of 188-192 THz. Gain variation < 2.1 dB has obtained. Highest output power has also obtained at 5 mW, 7Mw and 17 mW accordingly. Final conclusion has recommended that better gain flatness has attained without using any costly components such as gain equalizer and multi-pumping for SD-WDM system

A stress analysis method for fatigue life prediction of welded structures

In the case of structural weldments, the procedure for estimating fatigue life requires information concerning geometry of the object, loads and material. Detailed knowledge of stress fields in the critical regions of weldments is used to determine the fatigue life. The main theme of the research discussed in this thesis is to provide details of the methodology which has been developed to determine peak stress and associated non-linear through thickness stress distribution at the critical weld toe location by using only the geometry dependent stress concentration factors along with appropriate unique reference stress calculated in an efficient manner e.g. without modeling geometrical weld toe details. The peak stress at the weld toe can be subsequently used for estimating the fatigue crack initiation life. The non-linear through thickness stress distribution and the weight function method can be used for the determination of stress intensity factors and for the analysis of subsequent fatigue crack growth. Accurate peak stress estimation requires 3D fine mesh finite element (FE) models, accounting for the micro-geometrical features, such as the weld toe angle and weld toe radius. Such models are computationally expensive and therefore impractical. On the other hand, stresses at sharp weld corners obtained from 3D coarse FE meshes are inaccurate and cannot be used directly for fatigue life estimations. A robust, sufficiently accurate, efficient and practical approach is proposed for fatigue life estimation of welded structures based on 3D coarse mesh FE models. Another objective is to establish a methodology which is capable of accounting for the actual variability of stress concentration factors at welds, welding defects such as misalignment and incomplete penetration resulting from manufacturing processes. The proposed approach is capable of accounting for the effects from use of different material and effect of residual stresses from welding process. Residual stress information is obtained from a welding process simulation model, which has been validated against measured residual stress data. The proposed methodology has been validated using numerical and experimental data by analyzing different weldments of varying geometrical and load configurations. Further, the applicability of the stress field obtained from the proposed methodology is demonstrated by using it in a forward looking “Total Fatigue Life” concept based only on the fracture mechanics approach

Impact of High Speed Differential Quadrature Amplitude Modulation using Hybrid Optical Amplifier for Super Dense Wavelength Division Multiplexing System

In this paper, a Differential Quadrature Amplitude Modulation (DQAM) technique for 200 x100 Gbps Super Dense Wavelength Division Multiplexing (SD-WDM) system is proposed. Optimized rating outcome in terms of the quality factor, bit error rate, crosstalk, and acceptable minor effect of the channel spacing with the support of RAMAN-EDFA-RAMAN Hybrid Optical Amplifier (HOA) is reported

Impact of High Speed Differential Quadrature Amplitude Modulation using Hybrid Optical Amplifier for Super Dense Wavelength Division Multiplexing System

624-628In this paper, a Differential Quadrature Amplitude Modulation (DQAM) technique for 200 x100 Gbps Super Dense Wavelength Division Multiplexing (SD-WDM) system is proposed. Optimized rating outcome in terms of the quality factor, bit error rate, crosstalk, and acceptable minor effect of the channel spacing with the support of RAMAN-EDFA-RAMAN Hybrid Optical Amplifier (HOA) is reported

Optimization of Hybrid RAMAN-EDFA-RAMAN Optical Amplifier for Super Dense Wavelength Division Multiplexing System

In this paper, we have projected a new optimization approach for Super Dense Wavelength Division Multiplexing (SD-WDM) system with the help of RAMAN-EDFA-RAMAN hybrid optical amplifier (HOA). Evaluation is accomplished with respect to quality factor, noise figure, output power, RAMAN pumps, RAMAN fiber length and effect of jitter. Best rating parameters are noticed for getting the acceptable performance from the proposed system. Further,  evaluation with different dispersion ratings such as 2, 4, 6, and  10 ps/nm/km are made. Furthermore,it is also observed that optimization rating of dispersion at 2 ps/nm/km declares to cover the maximum span distance up to 200 km with the high-quality factor

Optimization of Hybrid RAMAN-EDFA-RAMAN Optical Amplifier for Super Dense Wavelength Division Multiplexing System

845-849In this paper, we have projected a new optimization approach for Super Dense Wavelength Division Multiplexing (SD-WDM) system with the help of RAMAN-EDFA-RAMAN hybrid optical amplifier (HOA). Evaluation has accomplished with respect to quality factor, noise figure, output power, RAMAN pumps, RAMAN fiber length and effect of jitter. Best rating parameters have noticed for getting the acceptable performance from the proposed system. Further, evaluation with different dispersion ratings such as 2, 4, 6, and 10 ps/nm/km has also done. Furthermore, it has also observed that optimization rating of dispersion at 2 ps/nm/km declares to cover the maximum span distance up to 200 km with the high-quality factor

Prevalence and risk factors of soil transmitted helminths from rural field practice area of a tertiary care center from northern India

Background: Soil-transmitted helminths (STH) are a major public health problem in our country, affecting the physical growth and cognitive development. STH infections are considered a leading cause of sickness, absenteeism and disability adjusted life years lost. Aim of the study was to assess the prevalence and risk factors of soil transmitted helminths (STH) in Farrukhabad district, India. Methods: A total of 1203 study subjects from 602 eligible households fulfilling the eligibilty criteria. Thus equal number of children and adults were recruited from rural and urban areas. In each household, one child participant of the age 1-15 years and one adult, older than 15 years, and willing to participate, were eligible to participate in this study. All enrolled subjects were provided with a screw- capped plastic container to collect their stool sample. The following day, a field worker visited the subject’s home to collect the container. Saline and iodine wet preparations were examined for the presence of nematode ova. All positive stool samples were re-examined by the McMaster egg counting technique to quantify the number of eggs per gram of stool.Results: Overall prevalence of STH was 14.3% (95% CI 4.4-19.2) among study subjects. Hookworm was the predominant STH identified with a prevalence of 11.3% (95% CI 1.1-17.4), followed by Ascaris lumbricoides with a prevalence of 4.5% (95% CI 0.5-7.6). Prevalence of STH was observed to be 13.2% (95% CI 8.7-17.2) and 7.6% (95% CI 4.4-10.7) in rural and urban areas respectively. Age category, residing in a field-hut, presence of cat at home, presence of untrimmed nails, open air defaecation, habitually eating food that has fallen on the ground, not washing hands with soap and water after defaecation, and consumption of deworming tablet turned out to be independent risk factors for acquiring STH infection in our study.Conclusions: Identification of at-risk groups along with Strategic planning and health education, awareness campaigns along with mass drug administration could reduce the burden of STH significantly.

Models for Antitubercular Activity of 5′-O-[(N-Acyl)sulfamoyl]adenosines

The relationship between topological indices and antitubercular activity of 5′-O-[(N-Acyl)sulfamoyl]adenosines has been investigated. A data set consisting of 31 analogues of 5′-O-[(N-Acyl)sulfamoyl]adenosines was selected for the present study. The values of numerous topostructural and topochemical indices for each of 31 differently substituted analogues of the data set were computed using an in-house computer program. Resulting data was analyzed and suitable models were developed through decision tree, random forest and moving average analysis (MAA). The goodness of the models was assessed by calculating overall accuracy of prediction, sensitivity, specificity and Mathews correlation coefficient. Pendentic eccentricity index – a novel highly discriminating, non-correlating pendenticity based topochemical descriptor – was also conceptualized and successfully utilized for the development of a model for antitubercular activity of 5′-O-[(N-Acyl)sulfamoyl]adenosines. The proposed index exhibited not only high sensitivity towards both the presence as well as relative position(s) of pendent/heteroatom(s) but also led to significant reduction in degeneracy. Random forest correctly classified the analogues into active and inactive with an accuracy of 67.74%. A decision tree was also employed for determining the importance of molecular descriptors. The decision tree learned the information from the input data with an accuracy of 100% and correctly predicted the cross-validated (10 fold) data with accuracy up to 77.4%. Statistical significance of proposed models was also investigated using intercorrelation analysis. Accuracy of prediction of proposed MAA models ranged from 90.4 to 91.6%

Optimizacija kitozanskih filmova kao zamjena za životinjsku i humanu epidermu za in vitro permeaciju polarnih i nepolarnih lijekova

The present investigation is aimed at preparing chitosan films capable of simulating the flux of modal drugs, 5-fluorouracil (5-FU) and indomethacin (INDO), across rat, rabbit and human cadaver epidermal sheets. Application of statistical design revealed that the concentration of chitosan, crosslinking time and concentration of crosslinking agent significantly influenced the in vitro flux of 5-FU and INDO across chitosan films. Multiple linear regression revealed a linear influence of all these active variables on 5-FU and INDO flux. It was deduced from atomic absorption spectroscopic analyses, DSC and IR spectroscopic data that 5% (m/V) sodium tripolyphosphate (NaTPP) produced optimum crosslinking of chitosan films. The in vitro permeation of both 5-FU and INDO across optimized film formulations was found to be comparable to that obtained across rat, rabbit and human epidermal sheets. These results indicate that optimized chitosan films have a potential to be developed as a substitute for animal and human cadaver epidermal sheets for preliminary in vitro permeation studies.U radu je opisana priprava kitosanskih filmova pogodnih za simulaciju prijelaza modelnih lijekova, 5-fluorouracila (5-FU) i indometacina (INDO), kroz epidermalne slojeve štakora, zeca i čovjeka. Koncentracija kitosana, vrijeme umrežavanja i koncentracija reagensa za umrežavanje značajno su utjecale na in vitro prolaz 5-FU i INDO kroz kitosanske filmove. Multiplom linearnom regresijom pokazano je da sve navedene varijable imaju linearni utjecaj na prolaz 5-FU i INDO. Uz pomoć atomske apsorpcijske spektralne analize, DSC i IR spektroskopskih podataka zaključeno je da je 5%-tna (m/V) otopina natrijevog tripolifosfata (NaTPP) najoptimalnija za umrežavanje kitosanskih filmova. Pronađeno je da je in vitro permeacija 5-FU i INDO kroz optimiziranu formulaciju kitozanskog filma usporediva s permeacijom kroz epidermalne slojeve štakora, zeca i čovjeka. Rezultati upućuju da se optimizirani kitozanski filmovi mogu upotrijebiti kao nadomjestak animalne i humane epiderme u preliminarnim in vitro permeacijskim istraživanjima

An evaluation of quality of life of skin cancer patients after surgery using dermatology life quality index tool

Background: Quality of life (QOL) has been identified as an important outcome in cancer researches yet the most common malignancy among humans, non-melanoma skin cancer (NMSC), but poorly studied. Aim of the study was to analyze the quality of life of non-melanoma skin cancer patients after surgery using dermatology life quality index inventory (DLQI).Methods: Retrospective cohort of patients operated for non-melanoma skin cancer in last 2 years and paid postoperative 4-month visit formed the study population. Inclusion criteria consisted of subjects operated for non-melanoma skin cancer and paid follow up visits having sufficient physical and mental capacity. Fifty-six subjects fulfilled the selection criteria laid down thus included in this study. Study tools were records of patients, which were obtained from medical records section. If any more information was required, study subjects were contacted.Results: Out of total 56 study subjects, Basal cell carcinomas were found in 91.1% (n=51); squamous cell carcinomas were detected in 7.2% (n=4). Single location wise more lesions were located on the nose 22.1% (n=15) and forehead 17.6% (12). For most patients (75%), the lesion had not been previously treated. 58.9% subjects did not have any other associated co-morbid condition. Lower mean values were observed post-operative i.e. lower DLQI scores were recorded 4 months after surgery in our study which indicates that adverse effects were not very prominent thus preserving quality of life post operatively. Paired sample t-tests revealed a significant effect on DLQI item 1 (p=0.008), item 2 (p=0.043), and item 4 (p=0.003), with scores decreasing (improving QOL) after treatment. The change in total DLQI score demonstrated a trend toward significance, with overall QOL improving after treatment (p=0.024).Conclusions: Previously commonly employed dermatological Quality of life tools demonstrated minimal handicap at initial diagnosis and little change after treatment of nonmelanoma skin cancer. Development of disease-specific instrument is warranted to explore the disease process.