A retrospective cross-sectional study of maxillofacial trauma in Delhi-NCR Region

Aim and Objectives: To evaluate the pattern, prevalence, etiology, site of fractures, and their management in patients with maxillofacial injury in Delhi-NCR region.Materials and Methods: A total of 1278 maxillofacial trauma patients visiting different registered hospitals from Delhi-NCR region from January 2012 to December 2017, treated by open reduction and internal fixation under general anesthesia (GA)/local anesthesia (LA) or closed reduction/conservatively, were taken into the study. The parameters considered in the study were age and sex distribution, etiological factors and incidence of maxillofacial trauma, pattern and site distribution of maxillofacial fractures, and management.Results: From a total of 2250 trauma patients, 1278 patients (1053 males and 225 females) had maxillofacial injury. The average prevalence rate was 56.8%. Yearly incidence rate was 20.4%. Road traffic accident (RTA) was the most common cause of trauma in 1029 (80.5%) patients, followed by physical assault [158 (12.3%)] with significant male predominance in different age groups. Isolated mandibular fractures were the most common [48.6% (parasymphysis 31.6%, condyle 28.2%)], followed by midface with maxilla fracture [27.6% (zygomatic bone and arch 50.2% and Lefort II fractures 18%)]. Treatment modalities were conservative management, closed reduction, and open reduction with internal fixation under GA/LA.Conclusion: RTA followed by physical assault is still the leading cause of maxillofacial trauma in young males in Delhi-NCR region. Mini plate osteosynthesis is the main treatment procedure for maxillofacial trauma. We need to enforce strict traffic rules, road safety law, and preventive measures along with improvement in education and socioeconomic status in the population to avoid maxillofacial injuries

Association between maternal dental anxiety and its effect on the oral health status of their child: An institutional cross sectional study

Aim: To assess the association between maternal dental anxiety and its effect on the oral health status of their child, in Murad nagar –An institutional cross-sectional study.Materials and Methods: Among the randomly selected 200 mother-child pairs, a cross-sectional study was done. The children of 2–5 years were selected for the study. A five-level Modified Dental Anxiety Scale (MDAS), Hindi edition, was used to assess dental anxiety among the mothers. Clinical examination of the wards was finished by using a modified gingival record and WHO dentition status (2013). The SPSS software version 20 was used for statistical analysis.Results: Approximately, 61% of the children were males, and 39% were females. The modified gingival index (MGI) score was high, if there should arise an occurrence of high MDAS values. The mean MGI score was most astounding in phobic class of MDAS and least in the not anxious classification. The MGI score expanded on increment in maternal anxiety. Dental caries expanded in kids, if there should be an occurrence of high maternal dental uneasiness. The MDAS demonstrated a critical association with clinical oral health results of the child. The children whose mothers were “extremely anxious” (phobic) had the highest mean decayed, missing, or filled teeth.Conclusion: Maternal dental anxiety significantly affects the oral health status of their ward

Comparative Study of Various Reactive MANET Protocols

Wireless ad hoc network acquired attention of research, as it does not require any infrastructure for its connectivity. So, it works independently with certain number of mobile nodes. The nodes used in the ad hoc are autonomous nodes which work as both the host and the route. The flexibility of nodes affects both the source and destination. Adaptive routing protocol establish specifically for the use of ad hoc environment that have at least one receiver .In this paper for the experimental purpose, Researcher studies about the adaptive routing protocol of the ad hoc network and compare its two protocol AODV which is a single path, loop free protocol while AOMDV uses multipath to communicate between single node and destination. Due to limited resources in MANETs the routing is vital issue

Protective Effect of Phyllanthus niruri on DMBA/Croton Oil Mediated Carcinogenic Response and Oxidative Damage in Accordance to Histopathological Studies in Skin of Mice

The current study has been designed to unveil the preventive effect of Phyllanthus niruri extract (PNE) on two stage skin carcinogenesis and oxidative damage in Swiss albino mice. Single topical application of 7, 12-dimethylbenz (a) anthracene (DMBA), followed by croton oil thrice weekly produced 100% incidence of tumors in carcinogen control animals (Gr. III) by 16 weeks. On the other hand, oral administration of animals with PNE (1 week before of DMBA application & continued until the end of experiment, Gr. IV), significantly reduced the tumor incidence, tumor burden, tumor volume and weight and the number of tumors but  prolong the latent period of tumor occurrence, as compared with carcinogen control animals. Furthermore, administration of PNE protected against the losses provoked in levels of glutathione, Vit.C, total proteins and activity of catalase and superoxide dismutase in skin and liver of animals by the application of DMBA/croton oil, concomitantly, the levels of lipid peroxidation were also reduced significantly. P. niruri administration profoundly reverted back the pathological changes observed in skin and liver of cancerous animals. From the results, P. niruri extract proves to scavenge free radical and found to be a potent chemopreventive agent against chemical induced skin carcinogenesis. Keywords: carcinogenesis, Phyllanthus niruri, cancer chemoprevention, tumor incidence, reactive oxygen species (ROS), antioxidant enzyme

Science Diplomacy - A New Chapter in IISF2020

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Tumor Biology and Immune Infiltration Define Primary Liver Cancer Subsets Linked to Overall Survival After Immunotherapy

Primary liver cancer is a rising cause of cancer deaths in the US. Although immunotherapy with immune checkpoint inhibitors induces a potent response in a subset of patients, response rates vary among individuals. Predicting which patients will respond to immune checkpoint inhibitors is of great interest in the field. In a retrospective arm of the National Cancer Institute Cancers of the Liver: Accelerating Research of Immunotherapy by a Transdisciplinary Network (NCI-CLARITY) study, we use archived formalin-fixed, paraffin-embedded samples to profile the transcriptome and genomic alterations among 86 hepatocellular carcinoma and cholangiocarcinoma patients prior to and following immune checkpoint inhibitor treatment. Using supervised and unsupervised approaches, we identify stable molecular subtypes linked to overall survival and distinguished by two axes of aggressive tumor biology and microenvironmental features. Moreover, molecular responses to immune checkpoint inhibitor treatment differ between subtypes. Thus, patients with heterogeneous liver cancer may be stratified by molecular status indicative of treatment response to immune checkpoint inhibitors

AgNOR as an effective diagnostic tool for determining the proliferative nature of different types of odontogenic cysts

Objective: To determine the proliferative nature of different types of odontogenic cysts using silver-stained nucleolar organizer region (AgNOR) staining.Materials and Methods: Forty histopathological sections of each of odontogenic keratocyst, dentigerous, and radicular growth were taken into study. Two sections were produced using the paraffin block of separate cases, one was stained with hematoxylin and eosin and another segment was stained with silver nitrate method.Results: AgNOR staining shows black dots and other parts of nuclei show yellow-brown dots.Conclusion: AgNOR, which stain for NOR-related proteins, corresponds to cell multiplication. Their amount regarding the number of AgNORs per cyst can be a good marker of the proliferative action of the cell in aggressive cystic lesion having malignant potential

Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract

Background: Cancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the cancer incidence. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and antioxidative potential of Panax ginseng against chemical-induced skin carcinogenesis in mammals. Methods: Skin tumors were induced in Swiss albino mice by a single topical application of 7,12-dimethylbenz(a)anthracene (100 μg/100 μL acetone) and, 2 wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% acetone) till the end of the experiment (i.e., 16 wk). Hydroalcoholic ginseng root extract at a dose of 25 mg/kg body weight/d was orally administered at the peri-initiation, postinitiation, and peri–post-initiation stages. Results: Ginseng root extract treatment caused a significant reduction in tumor incidence, cumulative number of tumors, tumor yield, and tumor burden, as compared to the 7,12-dimethylbenz(a)anthracene–croton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of reduced glutathione, superoxide dismutase, catalase, vitamin C, and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with ginseng root extract treatment, as compared to carcinogen-treated control group. Conclusion: These results suggest that P. ginseng has the potential to become a pivotal chemopreventive agent that can reduce cancer in mammals