3,669 research outputs found
The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi
Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient of a postdoctoral fellowship from FCT-Fundação para a Ciência e Tecnologia (SFRH/BPD/63733/2009). NG is funded by The Wellcome Trust (080088, 086827, 075470, 099215 & 097377), the FungiBrain Marie Curie Network and the Medical Research Council (UK).Peer reviewedPostprin
Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D. studentships for L.A.W. and K.K.L. We also acknowledge research grants from the Wellcome Trust (080088, 086827, 075470, 099215, and 097377) and the British Society for Antimicrobial Chemotherapy.Peer reviewedPublisher PD
Information seeking in the Humanities: physicality and digitality
This paper presents a brief overview of a research project
that is examining the information seeking practices of
humanities scholars. The results of this project are being
used to develop digital resources to better support these
work activities. Initial findings from a recent set of
interviews is offered, revealing the importance of physical
artefacts in the humanities scholars’ research processes and
the limitations of digital resources. Finally, further work
that is soon to be undertaken is summarised, and it is hoped
that after participation in this workshop these ideas will be
refined
Dissection of the Candida albicans class I chitin synthase promoters
We acknowledge financial support from the Biotechnology and Biological Sciences Research Council (10161), Medical Research Council (New Investigator Award to C.A.M.), the European Community FUNGALWALL and SIGNALPATH initiatives and the Wellcome Trust.Peer reviewedPublisher PD
In situ trap properties in CCDs: the donor level of the silicon divacancy
The silicon divacancy is one of the main defects of concern in radiation damage studies of Charge-Coupled Devices (CCDs) and, being immobile at room temperature, the defect is accessible to a variety of characterisation techniques. As such, there is a large amount of (often conflicting) information in the literature regarding this defect. Here we study the donor level of the divacancy, one of three energy levels which lie between the silicon valence and conduction bands. The donor level of the divacancy acts as a trap for holes in silicon and therefore can be studied through the use of a p-channel CCD.
The method of trap-pumping, linked closely to the process of pocket-pumping, has been demonstrated in the literature over the last two years to allow for in-situ analysis of defects in the silicon of CCDs. However, most work so far has been a demonstartion [sic] of the techinique [sic]. We begin here to use the technique for detailed studies of a specific defect centre in silicon, the donor level of the divacancy. The trap density post-irradiation can be found, and each instance of the trap identified independently of all others. Through the study of the trap response at different clocking frequencies one can measure directly the defect emission time constant, and through tracking this at different temperatures, it is possible to use Shockley-Read-Hall theory to calculate the trap energy level and cross-section.
A large population of traps, all with parameters consistent with the donor level of the divacancy, has been studied, leading to a measure of the distribution of properties. The emission time constant, energy level and cross-section are found to have relatively large spreads, significantly beyond the small uncertainty in the measurement technique. This spread has major implications on the correction of charge transfer inefficiency effects in space applications in which high precision is required
FOOD SAFETY IN THE MEAT INDUSTRY: A REGULATORY QUAGMIRE
Food Consumption/Nutrition/Food Safety, Livestock Production/Industries,
Cell wall stress induces alternative fungal cytokinesis and septation strategies
Peer reviewedPublisher PD
FIRMS, INCENTIVES, AND THE SUPPLY OF FOOD SAFETY: A FORMAL MODEL OF GOVERNMENT ENFORCEMENT
Recent instances of significant food safety breeches in both meat and biotechnology challenge traditional safety efforts. A formal model utilizing agency theory is used to explore the power relationships between the regulator and the firm. Fundamental issues effecting firms' supply of safety are demonstrated and alternative corrective mechanisms are discussed.Food Consumption/Nutrition/Food Safety,
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