The theory of remainders in the algebra of Grassmann

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Procédés de calcul en algèbre extérieure

info:eu-repo/semantics/publishe

First total synthesis of acetylenic alcohol 15-methyltricosa-2,4-diyne-1, 6-diol (strongylodiol-G) derived from marine sponge

<div><p>The first total and efficient synthesis of a naturally occurring acetylenic alcohol 15-methyltricosa-2,4-diyne-1,6-diol (strongylodiol-G) derived from marine sponge involving nine steps has been described. 1-Bromo-9-methyloctadecane (<b>5</b>) and hex-6-tetrahydropyranyloxyhex-2,4-diyn-1-al (<b>9</b>) which were initially synthesised separately starting from 1,8-octanediol (<b>1</b>) and propargyl alcohol (<b>6</b>), respectively, have been used as the final intermediates to obtain the title compound. The key steps in the synthesis involved ionic liquid-mediated bromination of 1,8-octanediol (<b>1</b>), tetrahydropyranylation of 8-bromooctan-1-ol (<b>2</b>) using acidic ionic liquid [bmim]HSO₄ and monotetrahydropyranylation of hex-2,4-yn-1,6-diol (<b>7</b>) using ultrasonic energy.</p></div

Ultrasound promoted synthesis of (±)-8-hydroxy-5-isopropyl-8-methyl-6(<i>E</i>)nonen- 2-one ((±)-solanone hydrate) and 3,7-dimethyl -2(<i>E</i>),7-octadienylpropionate

1950-1953A facile synthesis of the title compounds has been accomplished using Zn-Cu couple catalyzed conjugate addition of allylic halides to α, β-unsaturated ketones initiated by ultrasonic waves under aqueous conditions and Horner-Wittig reaction using ethyl α-dimethylphosphonoacetate and NaH as base in dry THF as the key steps in overall good yields