427 research outputs found
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Integration of electro-optical mechanical systems and medicine: Where are we and where can we go?
Microfabricated chip technologies offer researchers novel types of analysis of human clinical samples. Current examples of such technology include DNA amplification and analysis,and fluorescent cell analysis by flow cytometry. Potential applications include the development of rapid techniques for examining large numbers of cells in tissue or blood. This paper will outline criteria that successful devices must satisfy
Different mirror, A
Includes bibliographical references.Mirrors grown in the crystalline structure ease manufacture of vertical-cavity lasers, which emit collimated circular beams and can form large two-dimensional arrays. The authors discuss the fabrication of the surface emitting laser mirrors. By means of techniques such as molecular beam epitaxy and metal-organic vapor phase epitaxy, hundreds of layers of semiconductor materials can be grown one on top of the other. By mixing and matching the materials to create "designer" alloys, it is possible to grow a crystalline structure with all the electrical and optical properties desired for its various parts. This method of tailoring semiconductor structures is called bandgap engineering. The principles of the mirrors and their applications are discussed.This work was sponsored by the U.S. Department of Energy under contract number DE-AC04-94AL85000
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Semiconductor microlasers with intracavity microfluidics for biomedical analyses
Recently demonstrated microfluidic chips have the potential to be useful bioanalytical tools for DNA, protein, and cellular studies. To realize this potential, means for introducing fluids, separating their components, and detection must be integrated onto the chip. The authors have investigated semiconductor laser microcavity spectroscopy as a means for ultrasensitive detection of various fluids, cells, and particulates. Two methods for implementing this laser device are illustrated. A scanning method for reading the light signals from a static fluid in the microcavity is presented. The device has a microfabricated flow structure formed between two surfaces, a vertical cavity surface-emitting laser and a glass dielectric mirror. The resonance frequencies of this Fabry-Perot microcavity are very sensitive to the dielectric properties of the fluids confined inside the cavity. Further, the resonance linewidth or cavity Q is sensitive to the optical length of the cavity, light absorption, and light scattering from the fluid and the surfaces forming the cavity. If cells or particulates are present in the fluid they confine light transverse to the cavity length and develop additional sub-frequencies between the Fabry-Perot frequencies. Thus, the spectrum of light emitted from or transmitted through the cavity comprises a wealth of information about the cavity contents
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development
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A Semiconductor Microlaser for Intracavity Flow Cytometry
Semiconductor microlasers are attractive components for micro-analysis systems because of their ability to emit coherent intense light from a small aperture. By using a surface-emitting semiconductor geometry, we were able to incorporate fluid flow inside a laser microcavity for the first time. This confers significant advantages for high throughput screening of cells, particulates and fluid analytes in a sensitive microdevice. In this paper we discuss the intracavity microfluidics and present preliminary results with flowing blood and brain cells
Effect of the GaAsP shell on optical properties of self-catalyzed GaAs nanowires grown on silicon
We realize growth of self-catalyzed core-shell GaAs/GaAsP nanowires (NWs) on
Si substrates using molecular-beam epitaxy. Transmission electron microscopy
(TEM) of single GaAs/GaAsP NWs confirms their high crystal quality and shows
domination of the zinc-blende phase. This is further confirmed in optics of
single NWs, studied using cw and time-resolved photoluminescence (PL). A
detailed comparison with uncapped GaAs NWs emphasizes the effect of the GaAsP
capping in suppressing the non-radiative surface states: significant PL
enhancement in the core-shell structures exceeding 2000 times at 10K is
observed; in uncapped NWs PL is quenched at 60K whereas single core-shell
GaAs/GaAsP NWs exhibit bright emission even at room temperature. From analysis
of the PL temperature dependence in both types of NW we are able to determine
the main carrier escape mechanisms leading to the PL quench
Auger decay of degenerate and Bose-condensed excitons in CuO
We study the non-radiative Auger decay of excitons in CuO, in which two
excitons scatter to an excited electron and hole. The exciton decay rate for
the direct and the phonon-assisted processes is calculated from first
principles; incorporating the band structure of the material leads to a
relatively shorter lifetime of the triplet state ortho excitons. We compare our
results with the Auger decay rate extracted from data on highly degenerate
triplet excitons and Bose-condensed singlet excitons in CuO.Comment: 15 pages, revtex, figures available from G. Kavoulaki
Statistical Mechanics of Dilute Batch Minority Games with Random External Information
We study the dynamics and statics of a dilute batch minority game with random
external information. We focus on the case in which the number of connections
per agent is infinite in the thermodynamic limit. The dynamical scenario of
ergodicity breaking in this model is different from the phase transition in the
standard minority game and is characterised by the onset of long-term memory at
finite integrated response. We demonstrate that finite memory appears at the
AT-line obtained from the corresponding replica calculation, and compare the
behaviour of the dilute model with the minority game with market impact
correction, which is known to exhibit similar features.Comment: 22 pages, 6 figures, text modified, references updated and added,
figure added, typos correcte
Quantum saturation and condensation of excitons in CuO: a theoretical study
Recent experiments on high density excitons in CuO provide evidence for
degenerate quantum statistics and Bose-Einstein condensation of this nearly
ideal gas. We model the time dependence of this bosonic system including
exciton decay mechanisms, energy exchange with phonons, and interconversion
between ortho (triplet-state) and para (singlet-state) excitons, using
parameters for the excitonic decay, the coupling to acoustic and low-lying
optical phonons, Auger recombination, and ortho-para interconversion derived
from experiment. The single adjustable parameter in our model is the
optical-phonon cooling rate for Auger and laser-produced hot excitons. We show
that the orthoexcitons move along the phase boundary without crossing it (i.e.,
exhibit a ``quantum saturation''), as a consequence of the balance of entropy
changes due to cooling of excitons by phonons and heating by the non-radiative
Auger two-exciton recombination process. The Auger annihilation rate for
para-para collisions is much smaller than that for ortho-para and ortho-ortho
collisions, explaining why, under the given experimental conditions, the
paraexcitons condense while the orthoexcitons fail to do so.Comment: Revised to improve clarity and physical content 18 pages, revtex,
figures available from G. Kavoulakis, Physics Department, University of
Illinois, Urban
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