1,331 research outputs found
Investigation of test methods, material properties, and processes for solar cell encapsulants
The development of pottant compounds is emphasized. Formulation of the butyl acrylate syrup/casting pottant was completed. The formulation contains an ultraviolet stabilizer system and may be cured with an initiator that, unlike former selections, presents no shipping of handling hazards to the user. The catalyzed syrup is stable at room temperature and has a pot life of at least eight hours. The formulation of the ethylene/methyl acrylate lamination pottant was also completed. This compound is the alternative pottant to EVA and is similarly produced as an extruded sheet that is wound into rolls. This resin is inherently nonblocking
Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies.
Congenital diarrhoeal disorders (CDDs) represent an evolving web of rare chronic enteropathies, with a typical onset early in life. In many of these conditions, severe chronic diarrhoea represents the primary clinical manifestation, whereas in others diarrhoea is only a component of a more complex multi-organ or systemic disorder. Typically, within the first days of life, diarrhoea leads to a life-threatening condition highlighted by severe dehydration and serum electrolyte abnormalities. Thus, in the vast majority of cases appropriate therapy must be started immediately to prevent dehydration and long-term, sometimes severe, complications. The number of well-characterized disorders attributed to CDDs has gradually increased over the past several years, and many new genes have been identified and functionally related to CDDs, opening new diagnostic and therapeutic perspectives. Molecular analysis has changed the diagnostic scenario in CDDs, and led to a reduction in invasive and expensive procedures. Major advances have been made in terms of pathogenesis, enabling a better understanding not only of these rare conditions but also of more common diseases mechanisms
An Assessment to Benchmark the Seismic Performance of a Code-Conforming Reinforced-Concrete Moment-Frame Building
This report describes a state-of-the-art performance-based earthquake engineering methodology
that is used to assess the seismic performance of a four-story reinforced concrete (RC) office
building that is generally representative of low-rise office buildings constructed in highly seismic
regions of California. This “benchmark” building is considered to be located at a site in the Los
Angeles basin, and it was designed with a ductile RC special moment-resisting frame as its
seismic lateral system that was designed according to modern building codes and standards. The
building’s performance is quantified in terms of structural behavior up to collapse, structural and
nonstructural damage and associated repair costs, and the risk of fatalities and their associated
economic costs. To account for different building configurations that may be designed in
practice to meet requirements of building size and use, eight structural design alternatives are
used in the performance assessments.
Our performance assessments account for important sources of uncertainty in the ground
motion hazard, the structural response, structural and nonstructural damage, repair costs, and
life-safety risk. The ground motion hazard characterization employs a site-specific probabilistic
seismic hazard analysis and the evaluation of controlling seismic sources (through
disaggregation) at seven ground motion levels (encompassing return periods ranging from 7 to
2475 years). Innovative procedures for ground motion selection and scaling are used to develop
acceleration time history suites corresponding to each of the seven ground motion levels.
Structural modeling utilizes both “fiber” models and “plastic hinge” models. Structural
modeling uncertainties are investigated through comparison of these two modeling approaches,
and through variations in structural component modeling parameters (stiffness, deformation
capacity, degradation, etc.). Structural and nonstructural damage (fragility) models are based on
a combination of test data, observations from post-earthquake reconnaissance, and expert
opinion. Structural damage and repair costs are modeled for the RC beams, columns, and slabcolumn connections. Damage and associated repair costs are considered for some nonstructural
building components, including wallboard partitions, interior paint, exterior glazing, ceilings,
sprinkler systems, and elevators. The risk of casualties and the associated economic costs are
evaluated based on the risk of structural collapse, combined with recent models on earthquake
fatalities in collapsed buildings and accepted economic modeling guidelines for the value of
human life in loss and cost-benefit studies.
The principal results of this work pertain to the building collapse risk, damage and repair
cost, and life-safety risk. These are discussed successively as follows.
When accounting for uncertainties in structural modeling and record-to-record variability
(i.e., conditional on a specified ground shaking intensity), the structural collapse probabilities of
the various designs range from 2% to 7% for earthquake ground motions that have a 2%
probability of exceedance in 50 years (2475 years return period). When integrated with the
ground motion hazard for the southern California site, the collapse probabilities result in mean
annual frequencies of collapse in the range of [0.4 to 1.4]x10
-4
for the various benchmark
building designs. In the development of these results, we made the following observations that
are expected to be broadly applicable:
(1) The ground motions selected for performance simulations must consider spectral
shape (e.g., through use of the epsilon parameter) and should appropriately account for
correlations between motions in both horizontal directions;
(2) Lower-bound component models, which are commonly used in performance-based
assessment procedures such as FEMA 356, can significantly bias collapse analysis results; it is
more appropriate to use median component behavior, including all aspects of the component
model (strength, stiffness, deformation capacity, cyclic deterioration, etc.);
(3) Structural modeling uncertainties related to component deformation capacity and
post-peak degrading stiffness can impact the variability of calculated collapse probabilities and
mean annual rates to a similar degree as record-to-record variability of ground motions.
Therefore, including the effects of such structural modeling uncertainties significantly increases
the mean annual collapse rates. We found this increase to be roughly four to eight times relative
to rates evaluated for the median structural model;
(4) Nonlinear response analyses revealed at least six distinct collapse mechanisms, the
most common of which was a story mechanism in the third story (differing from the multi-story
mechanism predicted by nonlinear static pushover analysis);
(5) Soil-foundation-structure interaction effects did not significantly affect the structural
response, which was expected given the relatively flexible superstructure and stiff soils.
The potential for financial loss is considerable. Overall, the calculated expected annual
losses (EAL) are in the range of 97,000 for the various code-conforming benchmark
building designs, or roughly 1% of the replacement cost of the building (3.5M, the fatality rate translates to an EAL due to
fatalities of 5,600 for the code-conforming designs, and 66,000, the monetary value associated with life loss is small,
suggesting that the governing factor in this respect will be the maximum permissible life-safety
risk deemed by the public (or its representative government) to be appropriate for buildings.
Although the focus of this report is on one specific building, it can be used as a reference
for other types of structures. This report is organized in such a way that the individual core
chapters (4, 5, and 6) can be read independently. Chapter 1 provides background on the
performance-based earthquake engineering (PBEE) approach. Chapter 2 presents the
implementation of the PBEE methodology of the PEER framework, as applied to the benchmark
building. Chapter 3 sets the stage for the choices of location and basic structural design. The subsequent core chapters focus on the hazard analysis (Chapter 4), the structural analysis
(Chapter 5), and the damage and loss analyses (Chapter 6). Although the report is self-contained,
readers interested in additional details can find them in the appendices
Analysis of Dynamic Load Factor in a Fail-safe Crane Equipped with a Hydraulic Equalizing Cylinder
A model is proposed for the dynamic behavior of an equalizing cylinder when coupled to a fail-safe crane mechanism. The constitutive equations involve the continuity of the fluid in the equilizing bar and time-dependent incompressible one-dimensional Navier-Stokes equations for the detailed motion of the cylinder coupled with the dynamics of the traveling block and the elastic cable. These yields a nonlinear 2nd-order ordinary differential equations. The results for the Dynamic Load Factor (DLF) is presented
Child Advocacy Studies (CAST): A National Movement to Improve the Undergraduate and Graduate Training of Child Protection Professionals
Relationship between alcohol use disorders, cortisol concentrations, and cytokine levels in patients with sepsis
Structural basis for the recognition and cleavage of histone H3 by cathepsin L
Proteolysis of eukaryotic histone tails has emerged as an important factor in the modulation of cell-cycle progression and cellular differentiation. The recruitment of lysosomal cathepsin L to the nucleus where it mediates proteolysis of the mouse histone H3 tail has been described recently. Here, we report the three-dimensional crystal structures of a mature, inactive mutant of human cathepsin L alone and in complex with a peptide derived from histone H3. Canonical substrate–cathepsin L interactions are observed in the complex between the protease and the histone H3 peptide. Systematic analysis of the impact of posttranslational modifications at histone H3 on substrate selectivity suggests cathepsin L to be highly accommodating of all modified peptides. This is the first report of cathepsin L–histone H3 interaction and the first structural description of cathepsin L in complex with a substrate
Biological invasions as a selective filter driving behavioral divergence
Biological invasions are a multi-stage process (i.e., transport, introduction, establishment, spread), with each stage potentially acting as a selective filter on traits associated with invasion success. Behavior (e.g., exploration, activity, boldness) plays a key role in facilitating species introductions, but whether invasion acts as a selective filter on such traits is not well known. Here we capitalize on the well-characterized introduction of an invasive lizard (Lampropholis delicata) across three independent lineages throughout the Pacific, and show that invasion shifted behavioral trait means and reduced among-individual variation-two key predictions of the selective filter hypothesis. Moreover, lizards from all three invasive ranges were also more behaviorally plastic (i.e., greater within-individual variation) than their native range counterparts. We provide support for the importance of selective filtering of behavioral traits in a widespread invasion. Given that invasive species are a leading driver of global biodiversity loss, understanding how invasion selects for specific behaviors is critical for improving predictions of the effects of alien species on invaded communities.Invasive species are a leading driver of global biodiversity loss. Here, the authors show that the process of invasion itself can promote behavioral changes important to the success of widespread invaders, with implications for understanding the effects of alien species on invaded communities
Multivisceral intestinal transplantation: Surgical pathology
We report the diagnostic surgical pathology of two children who underwent multivisceral abdominal transplantation and survived for 1 month and 6 months. There is little relevant literature, and diagnostic criteria for the various clinical possibilities are not established; this is made more complicated by the simultaneous occurrence of more than one process. We based our interpretations on conventional histology, augmented with immunohistology, including HLA staining that distinguished graft from host cells in situ. In some instances functional analysis of T cells propagated from the same biopsies was available and was used to corroborate morphological interpretations. A wide spectrum of changes was encountered. Graft-versus-host disease, a prime concern before surgery, was not seen. Rejection was severe in 1 patient, not present in the other, and both had evidence of lymphoproliferative disease, which was related to Epstein-Barr virus. Bacterial translocation through the gut wall was also a feature in both children. This paper documents and illustrates the various diagnostic possibilities.. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
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