Formation damage arising from barium sulphate scale precipitation

Formation of scale in oilfield pipework has long been a problem. It is also likely that scale might form in the near well-bore region of the reservoir. This thesis examines the simulation of the formation damage possible due to scale, supported by experiments involving mixing brines in sandstone cores. Simulation was performed using a network model to represent the sandstone. The model was "damaged" using precipitation theory and observations on the damage caused to experimental cores. Experiments were performed, using quarried sandstone, to provide data for tuning and matching the model. The experiments used a pressure-tapped core holder to provide more detailed information on the scaling process and a new, two fluid, injection system for better control over mixing of the brines. The experiments demonstrated that permeability loss would be most rapid in the initial stages of scaling. The rate of permeability loss decreased with decreasing supersaturation of the brine mix and Increasing distance from the point of mixing. Characterisation of the permeability decline demonstrated a linear correlation between the damage rate and the initial permeability. Some effects on permeability damage due to morphology of the scale crystals were noted. The crystal morphology was shown to be mainly dependant on the solution composition rather than its supersaturation. Results from the model indicated a great sensitivity to the "poro-perm" characteristics of the network model representing the sandstone. No matching of results to experiments was achieved, but the trends with relation to the permeability change were modelled successfully.BP Sunbury Research Centr

The barriers to and enablers of providing reasonably adjusted health services to people with intellectual disabilities in acute hospitals: evidence from a mixed-methods study.

OBJECTIVE: To identify the factors that promote and compromise the implementation of reasonably adjusted healthcare services for patients with intellectual disabilities in acute National Health Service (NHS) hospitals. DESIGN: A mixed-methods study involving interviews, questionnaires and participant observation (July 2011-March 2013). SETTING: Six acute NHS hospital trusts in England. METHODS: Reasonable adjustments for people with intellectual disabilities were identified through the literature. Data were collected on implementation and staff understanding of these adjustments. RESULTS: Data collected included staff questionnaires (n=990), staff interviews (n=68), interviews with adults with intellectual disabilities (n=33), questionnaires (n=88) and interviews (n=37) with carers of patients with intellectual disabilities, and expert panel discussions (n=42). Hospital strategies that supported implementation of reasonable adjustments did not reliably translate into consistent provision of such adjustments. Good practice often depended on the knowledge, understanding and flexibility of individual staff and teams, leading to the delivery of reasonable adjustments being haphazard throughout the organisation. Major barriers included: lack of effective systems for identifying and flagging patients with intellectual disabilities, lack of staff understanding of the reasonable adjustments that may be needed, lack of clear lines of responsibility and accountability for implementing reasonable adjustments, and lack of allocation of additional funding and resources. Key enablers were the Intellectual Disability Liaison Nurse and the ward manager. CONCLUSIONS: The evidence suggests that ward culture, staff attitudes and staff knowledge are crucial in ensuring that hospital services are accessible to vulnerable patients. The authors suggest that flagging the need for specific reasonable adjustments, rather than the vulnerable condition itself, may address some of the barriers. Further research is recommended that describes and quantifies the most frequently needed reasonable adjustments within the hospital pathways of vulnerable patient groups, and the most effective organisational infrastructure required to guarantee their use, together with resource implications

A Tale of Two Narrow-Line Regions: Ionization, Kinematics, and Spectral Energy Distributions for a Local Pair of Merging Obscured Active Galaxies

We explore the gas ionization and kinematics, as well as the optical--IR spectral energy distributions for UGC 11185, a nearby pair of merging galaxies hosting obscured active galactic nuclei (AGNs), also known as SDSS J181611.72+423941.6 and J181609.37+423923.0 (J1816NE and J1816SW, $z \approx 0.04$). Due to the wide separation between these interacting galaxies ($\sim 23$ kpc), observations of these objects provide a rare glimpse of the concurrent growth of supermassive black holes at an early merger stage. We use BPT line diagnostics to show that the full extent of the narrow line emission in both galaxies is photoionized by an AGN and confirm the existence of a 10-kpc-scale ionization cone in J1816NE, while in J1816SW the AGN narrow-line region is much more compact (1--2 kpc) and relatively undisturbed. Our observations also reveal the presence of ionized gas that nearly spans the entire distance between the galaxies which is likely in a merger-induced tidal stream. In addition, we carry out a spectral analysis of the X-ray emission using data from {\em XMM-Newton}. These galaxies represent a useful pair to explore how the [\ion{O}{3}] luminosity of an AGN is dependent on the size of the region used to explore the extended emission. Given the growing evidence for AGN "flickering" over short timescales, we speculate that the appearances and impact of these AGNs may change multiple times over the course of the galaxy merger, which is especially important given that these objects are likely the progenitors of the types of systems commonly classified as "dual AGNs."Comment: 15 pages, 10 figures, accepted by the Astrophysical Journa

Contribution of the Accretion Disk, Hot Corona, and Obscuring Torus to the Luminosity of Seyfert Galaxies: Integral and Spitzer Observations

We estimate the relative contributions of the supermassive black hole (SMBH) accretion disk, corona, and obscuring torus to the bolometric luminosity of Seyfert galaxies, using Spitzer mid-infrared (MIR) observations of a complete sample of 68 nearby active galactic nuclei (AGNs) from the INTEGRAL all-sky hard X-ray (HX) survey. This is the first HX-selected (above 15 keV) sample of AGNs with complementary high angular resolution, high signal-to-noise, MIR data. Correcting for the host galaxy contribution, we find a correlation between HX and MIR luminosities: L 15 μm∝L0.74 ± 0.06 HX. Assuming that the observed MIR emission is radiation from an accretion disk reprocessed in a surrounding dusty torus that subtends a solid angle decreasing with increasing luminosity (as inferred from the declining fraction of obscured AGNs), the intrinsic disk luminosity, L Disk, is approximately proportional to the luminosity of the corona in the 2-300 keV energy band, L Corona, with the L Disk/L Corona ratio varying by a factor of 2.1 around a mean value of 1.6. This ratio is a factor of ~2 smaller than for typical quasars producing the cosmic X-ray background. Therefore, over three orders of magnitude in luminosity, HX radiation carries a large, and roughly comparable, fraction of the bolometric output of AGNs. We estimate the cumulative bolometric luminosity density of local AGNs at ~(1-3) × 1040 erg s–1 Mpc–3. Finally, the Compton temperature ranges between kT c ≈ 2 and ≈6 keV for nearby AGNs, compared to kT c ≈ 2 keV for typical quasars, confirming that radiative heating of interstellar gas can play an important role in regulating SMBH growth

Functional and Structural Diversity of Bacterial Contact-Dependent Growth Inhibition Effectors

Bacteria live in complex communities and environments, competing for space and nutrients. Within their niche habitats, bacteria have developed various inter-bacterial mechanisms to compete and communicate. One such mechanism is contact-dependent growth inhibition (CDI). CDI is found in many Gram-negative bacteria, including several pathogens. These CDI+ bacteria encode a CdiB/CdiA two-partner secretion system that delivers inhibitory toxins into neighboring cells upon contact. Toxin translocation results in the growth inhibition of closely related strains and provides a competitive advantage to the CDI+ bacteria. CdiB, an outer-membrane protein, secretes CdiA onto the surface of the CDI+ bacteria. When CdiA interacts with specific target-cell receptors, CdiA delivers its C-terminal toxin region (CdiA-CT) into the target-cell. CdiA-CT toxin proteins display a diverse range of toxic functions, such as DNase, RNase, or pore-forming toxin activity. CDI+ bacteria also encode an immunity protein, CdiI, that specifically binds and neutralizes its cognate CdiA-CT, protecting the CDI+ bacteria from auto-inhibition. In Gram-negative bacteria, toxin/immunity (CdiA-CT/CdiI) pairs have highly variable sequences and functions, with over 130 predicted divergent toxin/immunity complex families. In this review, we will discuss biochemical and structural advances made in the characterization of CDI. This review will focus on the diverse array of CDI toxin/immunity complex structures together with their distinct toxin functions. Additionally, we will discuss the most recent studies on target-cell recognition and toxin entry, along with the discovery of a new member of the CDI loci. Finally, we will offer insights into how these diverse toxin/immunity complexes could be harnessed to fight human diseases