312 research outputs found
Citizen science to improve patient and public involvement in GUideline Implementation in oral health and DEntistry (the GUIDE platform)
Research Funding Wellcome Trust Institutional Strategic Support Fund at the University of Aberdeen Chief Scientist's Office of the Scottish Government's Health and Social Care Directorates ACKNOWLEDGEMENTS We would like to thank all citizens who joined and engaged with the GUIDE platform for their time, ideas and enthusiasm. We would like to thank NHS Education of Scotland for supporting the project. The GUIDE project was funded by the Wellcome Trust Institutional Strategic Support Fund at the University of Aberdeen. The Health Services Research Unit is funded by the Chief Scientist's Office of the Scottish Government's Health and Social Care Directorates.Peer reviewedPublisher PD
Review of Privade Provided Public Goods Literature
The intention is to do a summary of the private provision of public goods literature; it also has the goal of seeing that there is no match between the classic theory predictions and the reality and empirical data. Another objective is to find within the literature aspects not studied yet, and so indicate future research topicsPublic Goods
“The power imbalance was blown out the window”: : developing and implementing creative workshops to enhance communication of statistics in patient and public involvement in clinical trials
Acknowledgements We would like to thank workshop attendees: Sian Bevan, Richard Caie, Robert Cain, Graeme Clark, Suzie Cro, Heather Doran, Peter Flockhart, Sarah Gallagher, Sophie Greenwood, Brennan Kahan, Lynn Laidlaw, Carrol Lamouline, Sarah Markham, Marie McDevitt, Jen McGregor, David Mclernon, Tim Morris, Akshaykumar Patel, Linda Parton, Craig Ramsay, Kara-Louise Royle, Irene Soulsby, Nikki Totton, Irene Soulsby, Derek Stewart, Lisa Wilson, Roger Wilson. We would also like to thank Chris Redford at Nifty Fox for his visual work in the final workshop Funding This project was funded by the Institutional Support Seed Funding from the Wellcome Trust at the University of Aberdeen and the MRC/NIHR Trials Methodology Research Partnership grant TMRP/WG 12.Peer reviewe
Intergenerational transmission of non-communicable chronic diseases
We introduce a theoretical framework that contributes to the understanding of non-communicable chronic diseases' (NCDs) epidemics: even if NCDs are non-infectious diseases, they may spread due to the social transmission of unhealthy activities such as unhealthy diet, physical inactivity, and smoking. In particular, we study the intergener- ational dimension of this mechanism. We find that, due to the social transmission of NCDs, agents choose lower health conditions and higher unhealthy activities than what is socially optimal. Taxes on unhealthy activities, that may subsidize health investments, can be used to restore the social optimum. Finally, our model is consistent with the existence of regional asymmetries regarding the prevalence of obesity and NCDs
Involving patients and the public In sTatistIcal Analysis pLans (INITIAL) : A delphi survey
Funding Our project was funded by the MRC/NIHR Trials Methodology Research Partnership grant TMRP/WG/12. Tim P. Morris was funded by MRC grants MC_UU_00004/07 and MC_UU_00004/09. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We would like to thank all participants that took time to reply to our Delphi survey. We would also like to thank all participants that participated in the consultation process or made suggestions to the accompanying blog. They helped us develop the survey and improve its clarity. We would like to thank Clare Robertson for her helpful support during the Delphi’s survey set-up stage, and Karen Beveridge for her support in the organisation of the study.Peer reviewedPublisher PD
Cell wall modifications during fruit ripening: when a fruit is not the fruit
Textural changes that lead to softening of fruits are accompanied
by loss of neutral sugars, solubilisation and depolymerisation
of the polysaccharides of the cell wall, and
rearrangements of their associations, as the result of the combined
action of several cell wall-modifying enzymes, acting in
both pectic and hemicellulosic fractions. Recent studies on the
structure of the plant cell wall have disclosed a large number
and type of biochemical linkages between the components.
Such linkages are potential targets for enzymatic action and
draw attention to the putative involvement of several members
of enzymes able to act and modify its structure in a developmental
and coordinated way. Extensive work on fruit ripening
has been done using tomato (Solanum lycopersicum [Lycopersicon
esculentum Mill.]) as a plant model and the information
concerning fruits other than model species is fragmented and
incomplete. However, recent data from the literature had disclosed
that differences exist between fruits, and even between
cultivars of the same fruit species. These differences exist in the
type and extent of the modification of the polysaccharides of
the cell wall and in the expression and regulation of cell
wall-modifying enzymes. In addition, genetic manipulation
of cell wall-modifying genes re-opened the discussion about
the real effect of these enzymes in the cell wall and their
role in fruit softening. Moreover, the function of each enzyme
has been proposed based on its homology with other annotated sequences, but, in most cases, confirmation of activity
in planta and substrate specificity remains to be investigated.
This aspect and recognized limitations of the in vitro
enzymatic activity assays also need to be considered when discussing
their role. This paper provides a critical review on the
current knowledge concerning these differences and emphasises
the need of using other species and more accurate methodologies
to investigate general mechanisms and fruit specificities
of softening among different fleshy fruits
Patient and public involvement in numerical aspects of trials : a mixed methods theory-informed survey of trialists’ current practices, barriers and facilitators
Funding: BG was supported to develop this research by the Wellcome Trust Institutional Strategic Support Fund at the University of Aberdeen.Peer reviewedPublisher PD
- …