43 research outputs found
Novel chemoenzymatic oxidation of amines into oximes based on hydrolase-catalysed peracid formation
Baeyer-Villiger monooxygenase-catalyzed desymmetrizations of cyclobutanones. Application to the synthesis of valuable spirolactones
Simple and quick preparation of a-thiocyanate ketones in hydroalcoholic media. Access to 5-aryl-2-imino-1,3-oxathiolanes
Asymmetric chemoenzymatic synthesis of N-acetyl-alpha-amino esters based on lipase-catalyzed kinetic resolutions through interesterification reactions
Biocatalysed concurrent production of enantioenriched compounds through parallel interconnected kinetic asymmetric transformations
Parallel interconnected kinetic asymmetric transformations were performed in order to obtain enantioenriched derivatives starting from a set of racemic or prochiral compounds. Thus, in a one-pot reaction using two redox biocatalysts (a BVMO and an ADH) and a catalytic amount of cofactor that acts as a mediator, enantioenriched ketones, sulfoxides, and sec-alcohols were concurrently obtained in a strict parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations