Surface Effect of Alumina on the First Electronic Transition of Liquid Water Studied by Far-Ultraviolet Spectroscopy

The first electronic transition (<i>Ã</i> ← <i>X̃</i>) of liquid water (H₂O and D₂O) on an α-alumina substrate was studied using variable angle attenuated total reflection far-ultraviolet (VA-ATR-FUV) spectroscopy in the wavelength region 140–180 nm (8.86–6.89 eV). A variation in the penetration depth of the evanescent wave of a probe light (25–19 nm) directly determined individual FUV spectra associated with bulk water (distance from the alumina surface >2 nm) and interfacial water (<2 nm). We found that the <i>Ã</i> ← <i>X̃</i> band of the interfacial water was markedly blue-shifted and red-tailed relative to the bulk water. The electronic state difference of the interfacial water from the bulk water mainly arose from the hydrogen-bond structure and energy affected by the alumina surface

Electronic Transitions of Protonated and Deprotonated Amino Acids in Aqueous Solution in the Region 145–300 nm Studied by Attenuated Total Reflection Far-Ultraviolet Spectroscopy

The electronic transitions of 20 naturally occurring amino acids in aqueous solution were studied with attenuated total reflection far-ultraviolet (ATR-FUV) spectroscopy in the region from 145 to 300 nm. From the measured ATR spectra of sample solutions, the FUV absorption spectra attributed to the amino acids were separated from the intense solvent absorption by using a modified Kramers–Kronig transformation method. The FUV absorption spectra of the amino acids reflect the protonation states of the backbone and side-chain structures. The contributions of the side chains to the spectra were also examined from the difference spectra subtracting the corresponding Gly spectrum from each spectrum. The observed spectra were compared mostly with the electronic transition studies of the molecular fragments of the amino acids in gas phase. The FUV spectra of the amino acids exhibited the intra- and intermolecular electronic interactions of the solute–solute as well as the solute–solvent, and those are essential factors to elucidate UV photochemical processes of the amino acids in aqueous solution

乳癌術後に高カルシウム血症を契機に発見された悪性リンパ腫の１例

症例は52歳の女性で, 3年前に左乳癌で乳腺部分切除,腋窩リンパ節郭清を受けた.病理組織診断は乳頭腺管癌で, リンパ節転移はなかった. 最近, 倦怠感, 食欲低下, 腰痛が出現し, 他院で高カルシウム血症と大動脈周囲リンパ節の腫大を指摘され, 当科に紹介となった. CT で大動脈周囲のリンパ節は著明に腫大し, 血清の可溶性インターロイキン-2レセプターは8980U/mlと高値を示したことから悪性リンパ腫を強く疑った. ゾレドロン酸とエルカトニンを投与し,高カルシウム血症が改善した後,他院血液内科に転院となった.転院後,頚部のリンパ節生検で, CD5陽性びまん性大細胞型B細胞性リンパ腫と診断された. 化学療法が行われたが,7か月後に永眠された.（Kitakanto Med J 2014；64：159～163）A 52-year-old woman underwent partial mastectomy and axillary lymph-node dissection three years ago. The pathological diagnosis was papillotubular carcinoma and no metastases were found in axillary lymph nodes. Recently, the patient complained of general fatigue, appetite loss and lumbago, and consulted another hospital. Laboratory tests revealed hypercalcemia. CT showed para-aortic lymphadenopathy. The patient was transferred to our hospital. Because of para-aortic lymphadenopathy and the high level of soluble interleukin-2 receptor in serum,we suspected malignant lymphoma. After hypercalcemia was improved following administration of zoledronic acid hydrate and elcatonin, the patient was transferred to the department of hematology in another hospital. By cervical lymph node biopsy, the diagnosis was a CD5-positive diffuse large B-cell lymphoma. The patient was treated with chemotherapy, but died seven months later.（Kitakanto Med J 2014；64：159～163