In vitro study of baseline sensitivity of important fungi against different fungicides

Baseline sensitivity values of important phytopathogenic fungi were studied against fungicides. ED50, ED90 and MIC value of propiconazole for, Colletotrichum capsici, and Gloeosporium ampelophagum was in the range of 0.020-0.04 ?g/ml. ED50 values of tebuconazole for Alternaria alternata was 30.0 ?g/ml. Azoxystrobin was also tested for its ED50, ED90 and MIC values against Alternaria alternata, C. capsici, G. ampelophagum and Botrytis cinerea where the values were in the range of 0.019-50.0, 0.03-60.0 and 0.2-100.0 ?g/ml respectively. Baseline sensitivity values are important for the management of plant diseases and resistance development

Culture and physiological variability in Rhizoctonia solani, responsible for foliar and lesions on aerial part of soybean

Foliar blight of soybean is one of the major fungal diseases. Rhizoctonia solani isolated from soybean growing in tarai regions of Uttarakhand. Six isolates of R. solani has been characterized on the basis of cultural and physiological nature such as colony diameter, growth, colour and sclerotia formation were recorded. Potato Dextrose Agar (PDA) was found best for growth and development. Two isolates (Lakhimpur and Pantnagar) covered the whole plates (90 mm) in 48 hrs. However, maximum number of sclerotia and weight was recorded on Czapek Dox agar medium. Overall radial growth supporting is recorded Corn Meal Agar Medium. Varied range of temperatures i.e. 10, 15, 25, 30, 35 and 400C was tested and found better growth of different isolates of R. solani at 10 - 400C, with an optimum growth temperature at 300C. Isolates were grown on five broth media (Asthana & Hawkers, Potato Dextrose Agar, Czapek’s Dox Agar, Corn Meal Agar and Richards Agar) for fresh, dry weight and oat meal broth culture filtrates of all isolates was used in phytotoxic effects. It recorded that maximum fresh and dry weight was observed on corn meal agar medium. The maximum reduction in radical and plumule length of germinating seeds were recorded in Haldichaur isolate

Improvement of environmental performance of integrated steel sector through process integration & optimisation measures and innovative waste management practices

The metallurgical and mineral processing industries are always known to be major contributors to environmental pollution. Amongst them, the iron & steel sector finds predominance simply because of the significant volume of effluents, emissions and solid wastes generated from the various process streams. Over the last decade efforts have been made to reduce cnvironmetital pollution from the integrated steel sector through various process integration and optimisation measures as well as cleaner technology development. In addition, a large number of innovations in waste management have resulted in implementation of integrated waste management plans in the steel sector as well as development of ninny value-added products. This paper takes an overview of some of these developments that have contributed significantly to improved environmental performance of the integrated steel sector in India

An Emerging Trend in Tablet Technology:- Floating Tablets of Ranitidine HCl

The rationale of this research was to prepare a gastroretentive drug delivery system of Ranitidine HCL. Floating Drug delivery system used to target drug release in the stomach or to the upper part of the intestine. The oral delivery of Ranitidine is tested by preparing a non-disintegrating floating dosage form, which increase its absorption in the stomach by increasing the drug’s gastric residence time. The polymer PVC and Sodium bicarbonate was used as the gas–generating agents. Sodium bicarbonate causes the tablets to floats for more then 24hr. The prepared tablets were evaluated on their physicochemical properties and drug release characters. In-vitro release studies indicate that the Ranitidine release form the floating dosage form was uniform followed zero order release. A combination of sodium bicarbonate (70mg) and citric acid (15mg) was found to achieve Optimum in vitro buoyancy. The tablets with methocel K100 were found to float for longer duration of time as compared to formulations containing methocel K15M. The drug release from the tablets was sufficiently sustained.Keywords: Ranitidine; Floating tablets; Methoce

Extensions of sufficient conditions for starlikeness and convexity of order α for multivalent function

AbstractIn this paper, we obtain extensions of sufficient conditions for analytic functions f(z) in the open unit disk U to be starlike and convex of order α. Our results unify and extend some starlikeness and convexity conditions for analytic functions discussed by Mocanu (1988) [4], Uyanik et al. (2011) [3] and others

Fungicidal management of Alternaria alternata (Fr.) Keissler causing blight of gerbera (Gerbera jamesonii H. Bolus ex J.D. Hook)

Alternaria, the fungal pathogen has wide host range generally attacks the aerial parts of plants causing leaf spots and blights. Gerbera is a genus of ornamental flower plants. Gerbera plants are infected by many diseases. Different disease management practices are adopted in gerbera cultivation. The fungicidal management of Alternaria blight is one of the important strategies for the disease management in gerbera in polyhouse condition. In this study, preventive and curative fungicidal sprays were adopted for the management of blight disease in polyhouse. This study revealed that preventive fungicidal sprays were significant over curative fungicidal sprays for the management of Alternaria alternata blight of gerbera (Gerbera jamesonii H. Bolus ex J.D. Hook) in polyhouse. The preventive sprays made of Bordeaux mixture (0.6 %), tricyclazole (0.1%) and iprodione + carbendazim (0.1%) fungicides were found effective with 95.85 %, 96.59 % and 95.88 % disease control respectively, under polyhouse condition

Awareness, perception and practices regarding Breast-Feeding and IYCF Practices among mothers of Children Up to 2 Years in Two Districts of Central India: A Cross-Sectional Study

Background: Breastfeeding is an absolute necessary intervention for childhood survival. WHO/UNICEF have given utmost emphasis on first 1000 days of life comprising of 270 days in-utero and the first two years post birth as most vital period for nutritional interventions. [1] Infant and Young Child Feeding (IYCF) is a set of renowned and usual recommendations for appropriate feeding of new-born and children below two years of age. Aims & Objectives: To assess the awareness, perception and practices, regarding breast-feeding and IYCF practices among mothers of children up to 2 years, in two districts of Central India. Settings and Design: Cross Sectional Study. Materials and Methods: This Cross-sectional study was carried out in two districts of Central India from January 2021 to December 2021. The study subjects included 400 mothers of babies less than two years old, who had given consent.  Interpersonal interview using a pre-designed semi-structured questionnaire was carried out. Data was collected, compiled and analysed using SPSS 25.0 (Trial Version). Result: Only (58.60%) of respondents were completely knowledgeable about exclusive breastfeeding, the value of colostrum feeding, the advantages of breastfeeding (81.69%), and its early onset (64.75%), duration (71.25%), and frequency (74.50%). However, 50.25% of women lacked understanding about the ideal positioning and attachment of the infant to the breast. Conclusion: All beneficiaries should be shown demonstrations of all IYCF practices. Family members should also be counselled and encouraged to support IYCF practices

Comparative evaluation of anesthetic efficacy of warm, buffered and conventional 2% lignocaine for the success of inferior alveolar nerve block (IANB) in mandibular primary molars: A randomized controlled clinical trial

Background. Maintaining primary teeth in the oral cavity is of prime importance, and grossly carious teeth may require pulp therapy to this end. Pain on injection and incomplete anesthesia causes failure of the procedure, resulting in fear and anxiety. Various methods have evolved to overcome this, such as distraction, topical anesthesia, etc. A new technique gaining popularity in dentistry in recent times is the warming or buffering of the solution prior to administration. Thus the aim of this study was to compare and evaluate the anesthetic efficacy and the patient’s pain reaction to pre-warmed, buffered and conventional 2% lignocaine for the success of the inferior alveolar nerve block (IANB) technique in mandibular primary molars undergoing pulp therapy. Methods. In this randomized, split-mouth clinical trial, sixty children 6‒12 years of age, requiring pulp therapy bilaterally on mandibular primary molars, were administered conventional, buffered or pre-warmed 2% lignocaine on two separate appointments. Various parameters were assessed using objective and subjective scales. Results. Pre-warmed and buffered anesthetics resulted in less pain on injection (P<0.001, P<0.001) and during pulp therapy (P=0.001, P=0.014), faster onset of action (P=0.004, P=0.001), lower SEM Sound (P=0.035, P=0.028), Eye (P<0.001, P=0.013) and Motor (P=0.008, P=0.021) scores and shorter duration of action (P<0.001, P=0.015). No significant difference was found between the two modified solutions. Thus pre-warmed and buffered anesthetic solutions fared better than the conventional solution for all the parameters but had no advantage over each other. Conclusion. Buffering or pre-warming the anesthetic solution reduced pain on administration and during the procedures in children

Preparation and evaluation of mouth dissolving tablets of meloxicam

The aim of the present study was to develop evaluate mouth dissolving tablet of meloxicam. Drug delivery systems became sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, mouth dissolving or orally disintegrating tablets have gained considerable attention as a preferred alternative to conventional tablets due to better patient compliance. The most preferrable route of drug administration (e.g. oral) is limited to drug candidate that show poor permeability across the gastric mucosa and those, which are sparingly soluble. A large majority of the new chemical entities and many new existing drug molecules are poorly soluble, thereby limiting their potential uses and increasing the difficulty of formulating bioavailable drug products,so lastlly the purpose of this study was to grow mouth dissolve tablets of Meloxicam. Meloxicam is a newer selective COX-1 inhibitor. These tablets were prepared by wet granulation procedure. The tablets were evaluated for % friability, wetting time and disintegration time. Sublimation of camphor from tablets resulted in better tablets as compared to the tablets prepared from granules that were exposing to vacuum. The systematic formulation approach helped in understanding the effect of formulation processing variables.Keywords: Mouth dissolving tablet; Maloxicam; Bioavailability; NSAI